Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Donna Haynes-Johnson"'
Autor:
Sheela Bhattacharjee, Allan George, Scott G. Lundeen, Olivia Linton, Pamela Tannenbaum, Xuqing Zhang, Donna Haynes-Johnson, Tifanie Sbriscia, Zhihua Sui, Muh-Tsann Lai
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 134:51-58
Selective androgen receptor modulators (SARMs) are androgens with tissue-selective activity. SARMs that have anabolic activity on muscle while having minimal stimulatory activity on prostate are classified as SARM agonists. They can be used to preven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274894ce92f19f7cce1d2ec5e29622ad
https://doi.org/10.1016/j.jsbmb.2012.10.015
https://doi.org/10.1016/j.jsbmb.2012.10.015
Autor:
Zhihua Sui, Raymond A. Ng, Muh-Tsann Lai, Olivia Linton, Scott G. Lundeen, Sheela Bhattacharjee, George F. Allan, Tifanie Sbriscia, Donna Haynes-Johnson
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 110:207-213
Androgens are required for the maintenance of normal sexual activity in adulthood and for enhancing muscle growth and lean body mass in adolescents and adults. Androgen receptor (AR) ligands with tissue selectivity (selective androgen receptor modula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3967956d5c7bb78cbe93df34d78c81
https://doi.org/10.1016/j.jsbmb.2007.10.012
https://doi.org/10.1016/j.jsbmb.2007.10.012
Autor:
Olivia Linton, Tifanie Sbriscia, Xuqing Zhang, George F. Allan, Muh-Tsann Lai, Sheela Bhattacharjee, Zhihua Sui, Donna Haynes-Johnson, Scott G. Lundeen, Pamela Tannenbaum
Publikováno v:
Endocrine. 32:41-51
Androgen receptor (AR) ligands with tissue selectivity (selective androgen receptor modulators, or SARMs) have potential for treating muscle wasting, hypogonadism of aging, osteoporosis, female sexual dysfunction, and other indications. JNJ-28330835
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda1f9701470ab79fa74d84ce290bc93
https://doi.org/10.1007/s12020-007-9005-2
https://doi.org/10.1007/s12020-007-9005-2
JNJ-10280205 and JNJ-10287069: novel PDE5 inhibitors as clinical candidates for erectile dysfunction
Autor:
Zhihua Sui, T. Mathew John, Patricia Kraft, Weiqin Jiang, Sheela Bhattacharjee, Donna Haynes-Johnson, Scott G. Lundeen, Yuhong Qiu
Publikováno v:
International Journal of Impotence Research. 18:477-483
Phosphodiesterase 5 (PDE5) inhibitors are efficacious in treating patients with erectile dysfunction. New PDE5 inhibitors with different selectivity and pharmacokinetic profiles have been vigorously pursued. Here we report two novel, potent, and sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e861190c6419d5bc7576ba1fe3b3e74
https://doi.org/10.1038/sj.ijir.3901462
https://doi.org/10.1038/sj.ijir.3901462
Autor:
Michael R. D'Andrea, Donna Haynes-Johnson, Scott G. Lundeen, Yuhong Qiu, Patricia Kraft, Sheela Bhattacharjee
Publikováno v:
Journal of Histochemistry & Cytochemistry. 53:895-903
Cyclic nucleotide phosphodiesterase 11A (PDE11A) is the newest member in the PDE family. Although the tissue distribution of PDE11A mRNA has been shown, its protein expression pattern has not been well studied. The goal of this report is to investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7f4b139d0d58bb4a60051eaf7c61f5
https://doi.org/10.1369/jhc.5a6625.2005
https://doi.org/10.1369/jhc.5a6625.2005
Autor:
Jian-Zhong Guo, Scott G. Lundeen, George F. Allan, Sharon Hughes Tynan, Emmanuel Pacia, Donna Haynes-Johnson, Danielle Lawrence, Michael R. D'Andrea
Publikováno v:
Endocrinology. 146:1066-1073
Deleted in malignant brain tumors 1 (DMBT1) is a candidate suppressor of malignancies of the brain, lung, gut, and breast. We have been studying gene expression in the uterus in the presence of estrogens and their antagonists. Here, we show that DMBT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2078f12b8c11ddc26c5f5ba8fa378610
https://doi.org/10.1210/en.2004-1304
https://doi.org/10.1210/en.2004-1304
Autor:
Joanna Clancy, Weiqin Jiang, Elizabeth Craig, Donna Haynes-Johnson, T. Mathew John, Patricia Kraft, Zhihua Sui, Mark J. Macielag, Sheela Bhattacharjee, Jihua Guan, Scott G. Lundeen, Yuhong Qiu
Publikováno v:
European Journal of Pharmacology. 472:73-80
We have characterized a novel, potent, and selective phosphodiesterase type 5 inhibitor, JNJ-10258859 ((R)-(−)-3-(2,3-dihydro-benzofuran-5-yl)-2-[5-(4-methoxy-phenyl)-pyrimidin-2-yl]-1,2,3,4-tetrahydro-pyrrolo[3,4-b]quinolin-9-one). Its inhibitory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::791017e04b27dcb9f66397eb46dc9f1c
https://doi.org/10.1016/s0014-2999(03)01868-5
https://doi.org/10.1016/s0014-2999(03)01868-5
Autor:
Weiqin Jiang, Yuhong Qiu, Zhihua Sui, Patricia Kraft, Mark J. Macielag, T. Matthew John, Elizabeth Craig, Joanna Clancy, Sheela Bhattacharjee, Jihua Guan, Donna Haynes-Johnson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:761-765
A series of N(2)-furoyl and N(2)pyrimidinyl beta-carbolines was discovered to possess potent inhibitory activity against PDE5. During the synthesis we developed a tandem resin quenching protocol, which allowed us to synthesize large number of target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2413d565e29bc564da6c797b2216b0e4
https://doi.org/10.1016/s0960-894x(02)01036-3
https://doi.org/10.1016/s0960-894x(02)01036-3
Publikováno v:
Urology. 59:145-149
Objectives. To identify the phosphodiesterase (PDE) isoenzymes in the rabbit detrusor and to evaluate their roles in regulating detrusor muscular tone. Cyclic nucleotides are important secondary messengers involved in modulating the contractility of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9142a84ae8169b68333cadd255b47485
https://doi.org/10.1016/s0090-4295(01)01471-6
https://doi.org/10.1016/s0090-4295(01)01471-6
Publikováno v:
Urological Research. 29:388-392
Cyclic nucleotides are important secondary messengers involved in modulating the contractility of various smooth muscles. Phosphodiesterases (PDE) play important roles in this process by modulating the levels of cyclic nucleotides and their duration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f33b4585c9cd9e569180bc08dbe754
https://doi.org/10.1007/s00240-001-0221-6
https://doi.org/10.1007/s00240-001-0221-6