Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Donna Goguen"'
Autor:
Richard E. Brown, Andrew W. Stadnyk, Ryan V. Wheeler, Donna Goguen, Gloria J. Rodrigues, James H, Aimee A. Wong, Emre Fertan, Ian C. G. Weaver
Publikováno v:
The American Journal of Pathology. 189:1435-1450
Pathologic inflammation in response to injury, infection, or oxidative stress is a proposed mechanism relating cognitive decline to dementia. The kynurenine pathway and thioredoxin-interacting protein (TXNIP) activity regulate inflammation and neurot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021f5aeca9548066840769a049bcb41f
https://doi.org/10.1016/j.ajpath.2019.03.006
https://doi.org/10.1016/j.ajpath.2019.03.006
Publikováno v:
The American Journal of Pathology. 186:1582-1597
The fatal neurodegenerative disorder Niemann-Pick type C (NPC) is caused in most cases by mutations in NPC1, which encodes the late endosomal NPC1 protein. Loss of NPC1 disrupts cholesterol trafficking from late endosomes to the endoplasmic reticulum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d22766fed517ff614600c4200ffbea21
https://doi.org/10.1016/j.ajpath.2016.02.012
https://doi.org/10.1016/j.ajpath.2016.02.012
Publikováno v:
Frontiers in Behavioral Neuroscience
The influence of early life experience and degree of parental-infant attachment on emotional development in children and adolescents has been comprehensively studied. Structural and mechanistic insight into the biological foundation and maintenance o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe7d364c8269d4b4a77b46792488924
https://doi.org/10.3389/fnbeh.2017.00041
https://doi.org/10.3389/fnbeh.2017.00041
Publikováno v:
Oncotarget
Cancer therapies that simultaneously target activated mammalian target of rapamycin (mTOR) and cell metabolism are urgently needed. The goal of our study was to identify therapies that effectively inhibited both mTOR activity and cancer cell metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d6e1a1061a50cd189c4e208ad15aa26
https://doi.org/10.18632/oncotarget.2818
https://doi.org/10.18632/oncotarget.2818
Publikováno v:
Neuroscience. 111:567-574
Several immediate-early genes have been shown to be induced in the rodent circadian pacemaker, the suprachiasmatic nucleus, by retinal illumination at night. We compared spontaneous and light-evoked levels of the immediate-early gene protein ZIF268 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e5d971967f94905d9e336a2f7910ae
https://doi.org/10.1016/s0306-4522(01)00609-1
https://doi.org/10.1016/s0306-4522(01)00609-1
Publikováno v:
Neuroscience Letters. 305:25-28
Pituitary adenylate cyclase activating polypeptide (PACAP38) is a putative neurochemical of the main retinal input to the mammalian circadian pacemaker housed in the suprachiasmatic nucleus (SCN). We assessed the phase-resetting effects of microinjec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc1a4639a0be08752fd55a727999ae8
https://doi.org/10.1016/s0304-3940(01)01796-7
https://doi.org/10.1016/s0304-3940(01)01796-7
Publikováno v:
Journal of Biological Rhythms. 14:275-280
Nocturnal light induces the expression of various immediate-early genes (IEGs) in the suprachiasmatic nucleus (SCN), the primary pacemaker of the circadian system of mammals, and causes phase shifts of behavioral rhythms. In the hamster SCN, some IEG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca987e21492e4b7ac302f1fabe2b17de
https://doi.org/10.1177/074873099129000687
https://doi.org/10.1177/074873099129000687
Publikováno v:
Molecular Brain Research. 67:247-257
Nocturnal light exposure induces immediate-early gene (IEG) expression in the hypothalamic suprachiasmatic nucleus (SCN) and causes phase shifts of activity rhythms in mammals. Some IEGs also show a circadian rhythm of expression in the SCN. While ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5d0d5f35aa3ccb22c2932316d0877e
https://doi.org/10.1016/s0169-328x(99)00074-1
https://doi.org/10.1016/s0169-328x(99)00074-1
Publikováno v:
Molecular Brain Research. 52:242-248
We have assessed whether melatonin can induce c-fos expression at various circadian phases, and whether melatonin can inhibit photically induced c-fos expression in the suprachiasmatic nucleus (SCN) in both rats and Syrian hamsters. Subcutaneous admi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26cc17d6a27abe69c3ae60211cff5818
https://doi.org/10.1016/s0169-328x(97)00260-x
https://doi.org/10.1016/s0169-328x(97)00260-x
Publikováno v:
Neuroscience letters. 384(3)
The suprachiasmatic nuclei (SCN) contain the dominant circadian pacemaker in the mammalian brain. Retinal illumination at specific circadian phases resets the circadian pacemaker and induces the expression of several transcription factors, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d7f78c772bf8d3e2ca23a407b67298
https://pubmed.ncbi.nlm.nih.gov/15955628
https://pubmed.ncbi.nlm.nih.gov/15955628