IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice.

Autor: Fernando M Botelho, Carla M T Bauer, Donna Finch, Jake K Nikota, Caleb C J Zavitz, Ashling Kelly, Kristen N Lambert, Sian Piper, Martyn L Foster, James J P Goldring, Jadwiga A Wedzicha, Jennifer Bassett, Jonathan Bramson, Yoichiro Iwakura, Matthew Sleeman, Roland Kolbeck, Anthony J Coyle, Alison A Humbles, Martin R Stämpfli

Publikováno v: PLoS ONE, Vol 6, Iss 12, p e28457 (2011)

Cigarette smoking is the main risk factor for the development of chronic obstructive pulmonary disease (COPD), a major cause of morbidity and mortality worldwide. Despite this, the cellular and molecular mechanisms that contribute to COPD pathogenesi

Externí odkaz: https://doaj.org/article/a66704c4920d4a94bf3ed0aae0e515f7

Antimicrobial Peptides SLPI and Beta Defensin-1 in Sputum are Negatively Correlated with FEV1

Autor: Mona Bafadhel, Samantha Thulborn, Donna Finch, L J Tregidgo, Jennifer L Cane

Publikováno v: International Journal of Chronic Obstructive Pulmonary Disease

Jennifer Cane,1,2 Laura Tregidgo,1 Samantha Thulborn,1,2 Donna Finch,3 Mona Bafadhel1,2 1Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK; 2Oxford NIHR Biomedical Research Centre, University of Oxford, Oxfo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4b0c7ee01506dbcac358d92ce2acf38
http://europepmc.org/articles/PMC8170372

Understanding the effects of IL-18 and IL-1β in a complex pro-inflammatory milieu. (44.11)

Autor: John Ferguson, Matt Sleeman, Emmanuel Briend, Donna Finch

Publikováno v: The Journal of Immunology. 188:44.11-44.11

Disease association studies suggest that the cytokines IL1 and IL18 play a role in exacerbations of Chronic Obstructive Pulmonary Disease. A classical role of IL18 is to stimulate NK and T-Cells to produce IFNγ, a cytokine associated with viral exac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf4e29da51c3a435d53cc90a668172f8
https://doi.org/10.4049/jimmunol.188.supp.44.11

Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming

Autor: Cooles, Faye, Tarn, Jessica, Lendrem, Dennis, Naamane, Najib, Lin, Chung Ma, Millar, Ben, Maney, Nicola, Anderson, Amy, Thalayasingam, Nishanthi, Diboll, Julie, Bondet, Vincent, Duffy, Darragh, Barnes, Michael, Smith, Graham, Ng, Sandra, Watson, David, Henkin, Rafael, Cope, Andrew, Reynard, Louise, Pratt, Arthur, Isaacs, John

Publikováno v: Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases, In press, ⟨10.1136/annrheumdis-2022-222370⟩
Cooles, F A H, Tarn, J, Lendrem, D W, Naamane, N, Lin, C M A, Millar, B, Maney, N J, Anderson, A E, Thalayasingam, N, Diboll, J, Bondet, V, Duffy, D, Barnes, M R, Smith, G R, Ng, S, Watson, D, Henkin, R, Cope, A P, Reynard, L N, Pratt, A G & Isaacs, J D 2022, ' Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming ', Annals of the rheumatic diseases, vol. 81, no. 9, heartjnl-2022-222370, pp. 1214-1223 . https://doi.org/10.1136/annrheumdis-2022-222370
Ann Rheum Dis

ObjectivesAn interferon (IFN) gene signature (IGS) is present in approximately 50% of early, treatment naive rheumatoid arthritis (eRA) patients where it has been shown to negatively impact initial response to treatment. We wished to validate this ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ecfeba33e2085ceadcfd3a0dc4f6ae0
https://hal.science/hal-03699421/file/annrheumdis-2022-222370.full.pdf