Zobrazeno 1 - 10
of 306
pro vyhledávání: '"Donna E. Davies"'
Autor:
Joseph A. Bell, Elizabeth R. Davies, Christopher J. Brereton, Milica Vukmirovic, James J.W. Roberts, Kerry Lunn, Leanne Wickens, Franco Conforti, Robert A. Ridley, Jessica Ceccato, Lucy N. Sayer, David A. Johnston, Andres F. Vallejo, Aiman Alzetani, Sanjay Jogai, Ben G. Marshall, Aurelie Fabre, Luca Richeldi, Phillip D. Monk, Paul Skipp, Naftali Kaminski, Emily Offer, Yihua Wang, Donna E. Davies, Mark G. Jones
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101695- (2024)
Summary: Matrix stiffening by lysyl oxidase-like 2 (LOXL2)-mediated collagen cross-linking is proposed as a core feedforward mechanism that promotes fibrogenesis. Failure in clinical trials of simtuzumab (the humanized version of AB0023, a monoclonal
Externí odkaz:
https://doaj.org/article/28bf070de21f4af1b6319da757012509
Autor:
Zijian Xu, Elizabeth R. Davies, Liudi Yao, Yilu Zhou, Juanjuan Li, Aiman Alzetani, Ben G. Marshall, David Hancock, Tim Wallis, Julian Downward, Rob M. Ewing, Donna E. Davies, Mark G. Jones, Yihua Wang
Publikováno v:
Genes and Diseases, Vol 11, Iss 3, Pp 101065- (2024)
The factors that determine fibrosis progression or normal tissue repair are largely unknown. We previously demonstrated that autophagy inhibition-mediated epithelial–mesenchymal transition (EMT) in human alveolar epithelial type II (ATII) cells aug
Externí odkaz:
https://doaj.org/article/5746b35799c5474dafc24942f4b6652d
Autor:
Charlene Akoto, Anna Willis, Chiara F. Banas, Joseph A. Bell, Dean Bryant, Cornelia Blume, Donna E. Davies, Emily J. Swindle
Publikováno v:
Viruses, Vol 14, Iss 11, p 2430 (2022)
Mast cells (MCs) are classically associated with allergic asthma but their role in antiviral immunity is unclear. Human rhinoviruses (HRVs) are a major cause of asthma exacerbations and can infect and replicate within MCs. The primary site of HRV inf
Externí odkaz:
https://doaj.org/article/78bbb4542eb34e81bc0fb3609b6d5a7c
Autor:
Yilu Zhou, Charlotte Hill, Liudi Yao, Juanjuan Li, David Hancock, Julian Downward, Mark G. Jones, Donna E. Davies, Rob M. Ewing, Paul Skipp, Yihua Wang
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Alveolar type II (ATII) epithelial cells function as stem cells, contributing to alveolar renewal, repair and cancer. Therefore, they are a highly relevant model for studying a number of lung diseases, including acute injury, fibrosis and cancer, in
Externí odkaz:
https://doaj.org/article/361c15f17b4c4c1a8cffb2ee74a92261
Autor:
Cornelia Blume, Jonathan David, Rachel E. Bell, Jay R. Laver, Robert C. Read, Graeme C. Clark, Donna E. Davies, Emily J. Swindle
Publikováno v:
Pathogens, Vol 9, Iss 12, p 987 (2020)
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Externí odkaz:
https://doaj.org/article/b43dff569dd14801a1d57a63fe1fd874
Autor:
Yuan Yuan, Yilu Zhou, Yali Li, Charlotte Hill, Rob M. Ewing, Mark G. Jones, Donna E. Davies, Zhenglin Jiang, Yihua Wang
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 4, p 1371 (2020)
Hyperbaric oxygen (HBO) is widely applied to treat several hypoxia-related diseases. Previous studies have focused on the immediate effect of HBO-exposure induced oxidative stress on the lungs, but knowledge regarding the chronic effects from repetit
Externí odkaz:
https://doaj.org/article/a7af63f3d61f470c8620ec7224e0c2af
Autor:
Cornelia Blume, Jonathan David, Rachel E. Bell, Jay R. Laver, Robert C. Read, Graeme C. Clark, Donna E. Davies, Emily J. Swindle
Publikováno v:
Pathogens, Vol 5, Iss 3, p 53 (2016)
The bronchial epithelium provides protection against pathogens from the inhaled environment through the formation of a highly-regulated barrier. In order to understand the pulmonary diseases melioidosis and tularemia caused by Burkholderia thailanden
Externí odkaz:
https://doaj.org/article/cd648c8173fd4a08bd507ec171e16d99
Autor:
Michael Eyres, Joseph A. Bell, Elizabeth R. Davies, Aurelie Fabre, Aiman Alzetani, Sanjay Jogai, Ben G. Marshall, David A. Johnston, Zijian Xu, Sophie V. Fletcher, Yihua Wang, Gayle Marshall, Donna E. Davies, Emily Offer, Mark G. Jones
A defining pathological feature of human lung fibrosis is localized tissue heterogeneity, which challenges the interpretation of transcriptomic studies that typically lose spatial information. Here we investigate spatial gene expression in diagnostic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c40bc01531a62cf3e61373c10a6403
https://eprints.soton.ac.uk/468826/
https://eprints.soton.ac.uk/468826/
Autor:
João Fernandes, Nikita Karra, Joel Bowring, Riccardo Reale, Jonathan James, Cornelia Blume, Theresa J. Pell, Wendy C. Rowan, Donna E. Davies, Emily J. Swindle, Hywel Morgan
A multichannel microfluidic platform for real-time monitoring of epithelial barrier integrity by electrical impedance has been developed. Growth and polarization of human epithelial cells from the airway or gastrointestinal tract was continuously mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e12574dfd78f6bcad58f82e191a0f3b
https://eprints.soton.ac.uk/456810/
https://eprints.soton.ac.uk/456810/
Autor:
Cornelia Blume, Claire L. Jackson, Paul Skipp, Jane S. Lucas, Donna E. Davies, Gabrielle Wheway
Publikováno v:
Airway cell biology and immunopathology.