Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Donna Donigi Gale"'
Autor:
Donald J. Kyle, Yakov Rotshteyn, E. A. M. Seeds, Clive P. Page, Gary Douglas, Perry V. Halushka, Mark Chasin, Donna Donigi Gale, Tatsui Matsumoto, David Cavalla, Ronald M. Burch, Katherine H Banner, Nandini Banik, Domenico Spina, Forrest L. Smith, Richard H. Wong, Selina Harrison, Peter Hofer, Stephan Jordan
Publikováno v:
Pulmonary pharmacologytherapeutics. 16(2)
V11294 is a new cyclic nucleotide phosphodiesterase type 4 (PDE4) inhibitor of the rolipram class. In this report we present the pharmacological profile of V11294. V11294 inhibited PDE4 isolated from human lung with IC 50 405 nM, compared to 3700 nM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321edc1df35435caec0a27fa42c6fc75
https://pubmed.ncbi.nlm.nih.gov/12670778
https://pubmed.ncbi.nlm.nih.gov/12670778
Autor:
Donna Donigi, Gale, Linda J, Landells, Domenico, Spina, Alan J, Miller, Kate, Smith, Terry, Nichols, Yakov, Rotshteyn, Alfred, Tonelli, Peter, Lacouture, Ronald M, Burch, Clive P, Page, Brian J, O'Connor
Publikováno v:
British journal of clinical pharmacology. 54(5)
To assess the pharmacokinetic and pharmacodynamic profile of the novel PDE4 inhibitor V11294A (3-(3-cyclopentyloxy-4-methoxybenzyl)-6-ethylamino-8-isopropyl-3H purine hydrochloride) in healthy male volunteers.This was a double-blind, single dose, ran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fab102809bea3937a5e59edc48d96ee3
https://pubmed.ncbi.nlm.nih.gov/12445026
https://pubmed.ncbi.nlm.nih.gov/12445026
Publikováno v:
Gastroenterology. 102(1)
The ability of nonsteroidal anti-inflammatory drugs to exacerbate experimental colitis, and the possible contributions of the "shunting" of arachidonate via the 5-lipoxygenase pathway, were investigated using a rat model in which colitis was induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d26172d3ed83d70c2683d70353c4702
https://pubmed.ncbi.nlm.nih.gov/1309357
https://pubmed.ncbi.nlm.nih.gov/1309357