Výsledky vyhledávání - "Donna Cosgrove"

Effects of MiR-137 genetic risk score on brain volume and cortical measures in patients with schizophrenia and controls

Autor: David Mothersill, Richard Anney, Michael Conlon O'Donovan, Aiden Corvin, Laurena Holleran, Alexander Richards, Michael Gill, Donna Cosgrove, Sinead Kelly, Michael John Owen, Laura Whitton, Derek W. Morris, Gary Donohoe, Kiran Kumar Mantripragada, Jessica Holland, Denise Harold

Publikováno v: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 177:369-376

Multiple genome-wide association studies of schizophrenia have implicated genetic variants within the gene encoding microRNA-137. As risk variants within or regulated by MIR137 have been implicated in memory performance, we investigated the additive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab31b7bec08e98a0a535f83d498efd67
https://doi.org/10.1002/ajmg.b.32620

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Cognitive Characterization of Schizophrenia Risk Variants Involved in Synaptic Transmission: Evidence of CACNA1C's Role in Working Memory

Autor: Michael Conlon O'Donovan, Bettina Konte, Michael Gill, Alexander Richards, Annette M. Hartmann, Aiden Corvin, Gary Donohoe, Kimberley Kendall, Donna Cosgrove, Omar Mothersill, Denise Harold, Michael John Owen, Kiran Kumar Mantripragada, Dan Rujescu, Ina Giegling, James T.R. Walters, Derek W. Morris

Publikováno v: Neuropsychopharmacology. 42:2612-2622

With 4100 common variants associated with schizophrenia risk, establishing their biological significance is a priority. We sought to establish cognitive effects of risk variants at loci implicated in synaptic transmission by (1) identifying GWAS schi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f944db2093fddee4486215a28fa5573
https://doi.org/10.1038/npp.2017.123

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Genes influenced by MEF2C contribute to neurodevelopmental disease via gene expression changes that affect multiple types of cortical excitatory neurons

Autor: Gary Donohoe, Laura Whitton, Laura Fahey, Pilib Ó Broin, Donna Cosgrove, Derek W. Morris

Myocyte enhancer factor 2 C (MEF2C) is an important transcription factor during neurodevelopment. Mutation or deletion of MEF2C causes intellectual disability (ID) and common variants within MEF2C are associated with cognitive function and schizophre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f810c89f1a7da62915b4d747d23fbc1

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Beyond C4: Analysis of the complement gene pathway shows enrichment for IQ in patients with psychotic disorders and healthy controls

Autor: Derek W. Morris, Gary Donohoe, Donna Cosgrove, Laura Whitton, Denise Harold, Jessica Holland, Michael Gill, David Mothersill, Aiden Corvin

Publikováno v: Frontiers in Immunology

Variation in cognitive performance, which strongly predicts functional outcome in schizophrenia (SZ), has been associated with multiple immune‐relevant genetic loci. These loci include complement component 4 (C4A), structural variation at which was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc14c185eea08c30fb3586251f7ea0ac
https://pubmed.ncbi.nlm.nih.gov/31867012

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The Relationship Between Polygenic Risk Scores and Cognition in Schizophrenia

Autor: Laura Ferraro, Michael John Owen, Tracey L. Petryshen, Franziska Degenhardt, Derek W. Morris, Alexander Richards, Aura Frizzati, Ingrid Agartz, Leonhard Lennertz, Ingrid Melle, Fabian Streit, Jim van Os, Bart P. F. Rutten, Bettina Konte, Valentina Escott-Price, Annette M. Hartmann, Håkan Nyman, Ole A. Andreassen, Jana Strohmaier, Diego Quattrone, John Hubert, Gary Donohoe, Sophie E. Legge, Roel A. Ophoff, Loes M. Olde Loohuis, Amy Lynham, Dan Rujescu, Gabriëlla A.M. Blokland, James T.R. Walters, Jeanne E. Savage, Peter Holmans, Craig Morgan, Erik G. Jönsson, Robin M. Murray, Neeltje E.M. van Haren, Kjetil Sundet, Charlotte Gayer-Anderson, Antonio F. Pardiñas, Donna Cosgrove, Michael Wagner, Marcella Rietschel, Michael Conlon O'Donovan, Aiden Corvin, Patrick F. Sullivan, Thomas Espeseth, Ina Giegling, Katherine E. Tansey, Srdjan Djurovic

Publikováno v: Schizophrenia bulletin 46, sbz061 (2019). doi:10.1093/schbul/sbz061
Schizophrenia Bulletin, 46(2), 336-344. Oxford University Press
Schizophrenia Bulletin
Schizophrenia bulletin, 46(2), 336-344. Oxford University Press
GROUP Investigators, EUGEI WP2 Group & Schizophrenia Working Group of the Psychiatric Genomics Consortium 2020, ' The Relationship Between Polygenic Risk Scores and Cognition in Schizophrenia ', Schizophrenia bulletin, vol. 46, no. 2, pp. 336-344 . https://doi.org/10.1093/schbul/sbz061

Background Cognitive impairment is a clinically important feature of schizophrenia. Polygenic risk score (PRS) methods have demonstrated genetic overlap between schizophrenia, bipolar disorder (BD), major depressive disorder (MDD), educational attain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddac06cf8c487c5349f058ab5f3aebe4
https://pub.dzne.de/record/151594

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Genetically predicted complement component 4A expression: effects on memory function and middle temporal lobe activation

Autor: Gary Donohoe, Michael Gill, Donna Cosgrove, Jessica Holland, Michael Conlon O'Donovan, David Mothersill, Kiran Kumar Mantripragada, Michael John Owen, Alexander Richards, Simon McCarthy-Jones, Aiden Corvin, Derek W. Morris, Denise Harold

Publikováno v: Psychological Medicine

Background The longstanding association between the major histocompatibility complex (MHC) locus and schizophrenia (SZ) risk has recently been accounted for, partially, by structural variation at the complement component 4 (C4) gene. This structural

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ef7813cc8979dcb43bf06df05b8f08
http://hdl.handle.net/10379/15068

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The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: a collaborative cognitive and neuroimaging genetics project

Autor: Paul G. Nestor, James Lee, Vince D. Calhoun, Lynn E. DeLisi, Antje A. T. S. Reinders, Kang Sim, Neeltje E.M. van Haren, Robert W. McCarley, Anthony S. David, Wiepke Cahn, Timothea Toulopoulou, Martha E. Shenton, Paola Dazzan, Rick P.F. Wolthusen, Annette M. Hartmann, Bettina Konte, Randy L. Gollub, Jianjun Liu, Todd Lencz, Matcheri S. Keshavan, Erin W. Dickie, Jordan W. Smoller, Derek W. Morris, Lisa Osiecki, Esther Walton, Aristotle N. Voineskos, Sonja de Zwarte, Larry J. Seidman, Jill M. Goldstein, Stefan Ehrlich, New Fei Ho, Tiago Reis Marques, Marta Di Forti, Marek Kubicki, Daphne J. Holt, M. Aurora Falcone, Manuela Russo, Joey W. Trampush, Simone Ciufolini, Anil K. Malhotra, Joshua L. Roffman, Jessica A. Turner, S. Charles Schulz, Dara S. Manoach, Max Lam, René S. Kahn, Aiden Corvin, James T.R. Walters, Shaun Purcell, Elisabetta C. del Re, Jorge Jovicich, Valeria Mondelli, Ina Giegling, Elvira Bramon, Raquelle I. Mesholam-Gately, Donald C. Goff, Nasim Maleki, Michael Gill, Gary Donohoe, Dan Rujescu, Richard S.E. Keefe, Stephen L. Buka, Evangelos Vassos, Nicolas Crossley, Donna Cosgrove, Scott R. Sponheim, Sara Cherkerzian, Tracey L. Petryshen, Robin M. Murray, Marco Picchioni, Zora Kikinis, Gabriëlla A.M. Blokland, Heidi W. Thermenos, Sinead Kelly

Publikováno v: Schizophrenia Research
Blokland, G A M, Del Re, E C, Mesholam-Gately, R I, Jovicich, J, Trampush, J W, Keshavan, M S, DeLisi, L E, Walters, J T R, Malhotra, A K, Lencz, T, Shenton, M E, Voineskos, A N, Rujescu, D, Giegling, I, Kahn, R S, Roffman, J L, Holt, D J, Ehrlich, S, Kikinis, Z, Dazzan, P, Murray, R M, Di Forti, M, Lee, J, Sim, K, Lam, M, Wolthusen, R P F, de Zwarte, S M C, Walton, E, Cosgrove, D, Kelly, S, Maleki, N, Osiecki, L, Picchioni, M M, Bramon, E, Russo, M, Mondelli, V, Reinders, A A T S, Falcone, M A, Hartmann, A M, Konte, B, Gill, M, Corvin, A P, Cahn, W, Ho, N F, Keefe, R S E, Gollub, R L, Manoach, D S, Calhoun, V D, Schulz, S C, Sponheim, S R, Goff, D C, Buka, S L, Cherkerzian, S, Thermenos, H W, Kubicki, M, Nestor, P G, Dickie, E W, Vassos, E, Ciufolini, S, Reis Marques, T, Crossley, N A, Purcell, S M, Smoller, J W, van Haren, N E M, Toulopoulou, T, Donohoe, G, Goldstein, J M, Seidman, L J, McCarley, R W & Petryshen, T L 2017, ' The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium : A collaborative cognitive and neuroimaging genetics project ', Schizophrenia Research . https://doi.org/10.1016/j.schres.2017.09.024

Background: Schizophrenia has a large genetic component, and the pathways from genes to illness manifestation are beginning to be identified. The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) Consortium aims to clari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae7796603c9f44205204f450b6f78a4a
https://hdl.handle.net/11693/49946

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Genetic Risk Variants Interacting With MIR137: Effects On Cognition, Brain Structure And Brain Function In Patients And Healthy Participants

Autor: Gary Donohoe, Donna Cosgrove, David Motherills, Denise Harold, Sinead Kelly, Laurena Holleran, Jessica Holland, null Wellcome Trust CCC, Richard Anney, Alexander Richards, Michael Owen, Michael O'Donovan, Michael Gill, Aiden Corvin, Derek Morris

Publikováno v: European Neuropsychopharmacology. 29:S729-S730

Variants at microRNA-137 (MIR137), one of the most strongly associated schizophrenia risk loci identified to date, are associated with poorer cognitive performance. As microRNA-137 is known to regulate the expression of ~1900 other genes, including s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05a8280e63af7299ebc2958cbba359a2
https://doi.org/10.1016/j.euroneuro.2017.06.051

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