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Autor:
Peter H. Sayre, Janet Finer-Moore, Robert M. Stroud, Susan B. Gates, Donna Biermann, Mackellar Warren C, Vinod F. Patel, Timothy A Fritz
Publikováno v:
Journal of molecular biology. 313(4)
Crystal structures of four pyrrolo(2,3-d)pyrimidine-based antifolate compounds, developed as inhibitors of thymidylate synthase (TS) in a strategy to circumvent drug-resistance, have been determined in complexes with their in vivo target, human thymi