Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Donna A. Dickinson"'
Autor:
Jocelyn Moss, Jeffrey C. Bemis, Stephen D. Dertinger, Jared A. Mereness, Maik Schuler, Donna A. Dickinson, Richard A. Spellman, Steven M. Bryce
Publikováno v:
Environmental and Molecular Mutagenesis. 55:542-555
The specificity of in vitro mammalian cell genotoxicity assays is low, as they yield a high incidence of positive results that are not observed in animal genotoxicity and carcinogenicity tests, that is, "misleading" or "irrelevant" positives. We set
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5542da99026b04064d308f3db8b1a39
https://doi.org/10.1002/em.21868
https://doi.org/10.1002/em.21868
Autor:
Susan D. O'Lone, Maria Engel, Ronald D. Fiedler, Maik Schuler, Kelley E. Sanok, Krista L. Dobo, Catherine J. Thiffeault, Stephanie L. Coffing, Donna A. Dickinson, William C. Gunther, Thomas J. Shutsky
Publikováno v:
Environmental and Molecular Mutagenesis. 55:492-499
Ethyl methanesulfonate (EMS) was evaluated as part of the validation effort for the rat Pig-a mutation assay and compared with other well-established in vivo genotoxicity endpoints. Male Sprague-Dawley (SD) rats were given a daily dose of 0, 6.25, 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c0f71d6e3dccac49af2f77952153c43
https://doi.org/10.1002/em.21863
https://doi.org/10.1002/em.21863
Autor:
Catherine Spire, Anne-Celine Le Fevre, Heidrun Ellinger-Ziegelbauer, Olivier Grenet, Roger J. Smith, Gotaro Tanaka, Ronald D. Snyder, Shibing Deng, Masako Shiiyama, Jennifer Fostel, Yi-Zhong Gu, Chinami Aruga, Eric Boitier, Jiri Aubrecht, Albert J. Fornace, Jean-Christophe Hoflack, Donna A. Dickinson, Douglas C. Bauer
Publikováno v:
Toxicological Sciences. 110:341-352
The genotoxicity testing battery is highly sensitive for detection of chemical carcinogens. However, it features a low specificity and provides only limited mechanistic information required for risk assessment of positive findings. This is especially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f918a3b99670c26d7d30ba382a157029
https://doi.org/10.1093/toxsci/kfp103
https://doi.org/10.1093/toxsci/kfp103
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 575:34-46
Genotoxic stress triggers a variety of biological responses including the transcriptional activation of genes regulating DNA repair, cell survival and cell death. Genomic approaches, which monitor gene expressions across large numbers of genes, can s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d58ff1a7d97d550b3f65698c416ab4e5
https://doi.org/10.1016/j.mrfmmm.2005.02.005
https://doi.org/10.1016/j.mrfmmm.2005.02.005
Autor:
William C, Gunther, Stephanie L, Coffing, Donna A, Dickinson, Maria E, Engel, Ronald D, Fiedler, Susan D, O'Lone, Kelley E, Sanok, Catherine J, Thiffeault, Thomas J, Shutsky, Maik J, Schuler, Krista L, Dobo
Publikováno v:
Environmental and molecular mutagenesis. 55(6)
Ethyl methanesulfonate (EMS) was evaluated as part of the validation effort for the rat Pig-a mutation assay and compared with other well-established in vivo genotoxicity endpoints. Male Sprague-Dawley (SD) rats were given a daily dose of 0, 6.25, 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f283fe0fbef317707abfa4b5e8cf0816
https://pubmed.ncbi.nlm.nih.gov/24599777
https://pubmed.ncbi.nlm.nih.gov/24599777
Autor:
Stephanie L. Coffing, Andrew D. Scott, Richard A. Spellman, Michael Homiski, Krista L. Dobo, Donna A. Dickinson, Jennifer B. Munzner, Kelley E. Sanok, Maik Schuler, Jennifer R. Cheung, William C. Gunther, Dingzhou Li, Zhanna Sobol
Publikováno v:
Mutation research. 746(1)
The Organization for Economic Co-operation and Development (OECD) has recently adopted Test Guideline 487 (TG487) for conducting the in vitro micronucleus (MNvit) assay. The purpose of this study is to evaluate and validate treatment conditions for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3681288ca9cc18d8ecb2375d58002d
https://pubmed.ncbi.nlm.nih.gov/22445949
https://pubmed.ncbi.nlm.nih.gov/22445949
Autor:
Javed A. Bhalli, Maria Engel, Catherine J. Thiffeault, Ronald D. Fiedler, Mason G. Pearce, Zoryana Cammerer, Thomas J. Shutsky, Stephanie L. Coffing, Vasily N. Dobrovolsky, Xuefei Cao, Robert H. Heflich, William C. Gunther, Joseph G. Shaddock, Maik Schuler, Krista L. Dobo, Donna A. Dickinson
Publikováno v:
Environmental and molecular mutagenesis. 52(9)
N-Ethyl-N-nitrosourea (ENU) was evaluated as part of the Stage III trial for the rat Pig-a gene mutation assay. Groups of six- to eight-week-old male Sprague Dawley (SD) or Fischer 344 (F344) rats were given 28 daily doses of the phosphate buffered s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a99e0ee85a81564a9bc7d29a193ecb
https://pubmed.ncbi.nlm.nih.gov/22167886
https://pubmed.ncbi.nlm.nih.gov/22167886
Autor:
Catherine J. Thiffeault, Stephanie L. Coffing, Maik Schuler, Maria Engel, Donna A. Dickinson, Thomas J. Shutsky, Richard A. Spellman
Publikováno v:
Environmental and molecular mutagenesis. 52(4)
The in vivo bone marrow (BM) micronucleus assay is one of the three tests in the standard test battery to assess the genotoxic potential of a pharmaceutical candidate. In some cases, depending on results of in vitro studies, the route of administrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8843f254c15741ca56dc5b3bfd8503c1
https://pubmed.ncbi.nlm.nih.gov/20872852
https://pubmed.ncbi.nlm.nih.gov/20872852
Autor:
Maik Schuler, Nkechi Maduka, Maria Engel, Megan Colman, Ramadevi Gudi, Donna A. Dickinson, Jennifer R. Cheung, Shyam Kumar, Catherine J. Thiffeault, Jocelyn Sherman, Anna Szkudlinska
Publikováno v:
Mutation research. 702(2)
The in vitro micronucleus assay has been extensively used as an in vitro screening tool to identify test articles that might have aneugenic or clastogenic potential. Currently, the Organization for Economic Co-operation and Development (OECD) is work
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531c7b2736739b0238e1787771256ce9
https://pubmed.ncbi.nlm.nih.gov/20399283
https://pubmed.ncbi.nlm.nih.gov/20399283
Autor:
Anatoly Zhitkovich, Jiri Aubrecht, George Quievryn, Donna A. Dickinson, Gregory R. Warnes, Elizabeth Rubitski, Joseph Messer
Publikováno v:
Mutation research. 549(1-2)
Genotoxic stress triggers a variety of biological responses including the transcriptional activation of genes regulating DNA repair, cell survival and cell death. Here, we investigated whether gene expression profiles can differentiate between DNA re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b35ea8ed8fa43bf96820dfff91893fac
https://pubmed.ncbi.nlm.nih.gov/15120961
https://pubmed.ncbi.nlm.nih.gov/15120961