Výsledky vyhledávání - "Donna, Amrán"

Regulation of genistein-induced differentiation in human acute myeloid leukaemia cells (HL60, NB4)

Autor: Donna Amrán, Patricio Aller, Yolanda Sánchez, Elena de Blas

Publikováno v: Biochemical Pharmacology. 77:384-396

While it has been reported that genistein induces differentiation in multiple tumour cell models, the signalling and regulation of isoflavone-provoked differentiation are poorly known. We here demonstrate that genistein causes G(2)/M cycle arrest and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::10682f38f2ea3527028fac1c32285967
https://doi.org/10.1016/j.bcp.2008.10.035

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Arsenic trioxide sensitizes promonocytic leukemia cells to TNFα-induced apoptosis via p38-MAPK-regulated activation of both receptor-mediated and mitochondrial pathways

Autor: Consuelo Calle, Yolanda Sánchez, Patricio Aller, Carlos Fernández, Elena de Blas, Jacqueline Bréard, Donna Amrán, Adrian M. Ramos

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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11 páginas, 7 figuras -- PAGS nros. 1653-1663
Treatment with the anti-leukemic drug arsenic trioxide (As2O3, 1–4 μM) sensitizes U937 promonocytes and other human myeloid leukemia cell lines (HL60, NB4) to apoptosis induction by TNFα. As2O3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c54f4026f07e1600d2abb7d6488341
https://doi.org/10.1016/j.bbamcr.2007.06.003

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12-O-Tetradecanoylphorbol-13-acetate May Both Potentiate and Decrease the Generation of Apoptosis by the Antileukemic Agent Arsenic Trioxide in Human Promonocytic Cells

Autor: Patricio Aller, Carlos Fernández, Patricia Sancho, Elena de Blas, Adrian M. Ramos, Donna Amrán

Publikováno v: Journal of Biological Chemistry. 279:3877-3884

Arsenic trioxide (As2O3) caused apoptosis in U-937 human promonocytic cells. This effect was potentiated by the simultaneous addition of the glutathione (GSH) synthesis inhibitor dl-buthionine-(R,S)-sulfoximine or the protein kinase C activators 12-O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4829bd781d9a13a60cc06253a50b2099
https://doi.org/10.1074/jbc.m310665200

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Arsenic trioxide as an anti tumour agent. Mechanisms of action and strategies of sensitization

Autor: Yolanda Sánchez, Elena de Blas, Patricio Aller, Donna Amrán

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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10 páginas, 2 figuras -- PAGS nros. 199-208
Arsenic trioxide (As2O3, ATO) is a very efficacious, clinically established agent for the treatment of acute promyelocytic leukaemia, and also potentially useful against other haematological and non-h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e8f78fe6dde16ca2feb282a17629cf1
http://hdl.handle.net/10261/52384

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Regulation of genistein-induced differentiation in human acute myeloid leukaemia cells (HL60, NB4) Protein kinase modulation and reactive oxygen species generation

Autor: Yolanda, Sánchez, Donna, Amrán, Elena, de Blas, Patricio, Aller

Publikováno v: Biochemical pharmacology. 77(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1217b8ab0c39a87a0779ee4c7c3539a7
https://pubmed.ncbi.nlm.nih.gov/19038232

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Genistein selectively potentiates arsenic trioxide-induced apoptosis in human leukemia cells via reactive oxygen species generation and activation of reactive oxygen species-inducible protein kinases (p38-MAPK, AMPK)

Autor: Patricio Aller, Carlos Fernández, Elena de Blas, Donna Amrán, Yolanda Sánchez

Publikováno v: International journal of cancer. 123(5)

The observation that genistein may behave as a pro-oxidant agent lead us to examine the capacity of this isoflavone to modulate the toxicity of the oxidation-sensitive anti-leukemic agent arsenic trioxide (ATO), and for comparison other anti-tumor dr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd84a647a6716c1720b2ed1a078b4bbe
https://pubmed.ncbi.nlm.nih.gov/18546268

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Pharmacologic inhibitors of extracellular signal-regulated kinase (MEK/ERKs) and c-Jun NH2-terminal kinase (JNK) decrease glutathione content and sinsitize human promonocytic leukemia cells to arsenic trioxide-induced apoptosis

Autor: Diego Esteban, Patricio Aller, Carlos Fernández, Elena de Blas, M.A. Palacios, Donna Amrán, Adrian M. Ramos

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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10 páginas, 6 figuras -- PAGS nros. 1006-1015
Treatment with 1–4 µM As2O3 slightly induced apoptosis in U-937 human promonocitic leukemia cells. This effect was potentiated by co-treatment with MEK/ERK (PD98059, U0126) and JNK (SP600125, AS6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5f72ab429ca7b7b5b9bd479efa383d
http://hdl.handle.net/10261/66679

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Pharmacologic inhibitors of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathione depletion and increased peroxide accumulation in myeloid leukemia cells

Autor: Patricio Aller, Adrian M. Ramos, Carlos Fernández, Patricia Sancho, Elena de Blas, Donna Amrán

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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7 Figures. 1 Table. The publication costs of this article were defrayed in part by page charge payment. Therefore, and solely to indicate this fact, this article is hereby marked ‘‘advertisement’’ in accordance with 18 U.S.C. section 1734.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b9c7774ae1d45aab24f6ef85684cf2c
http://hdl.handle.net/10261/42223

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Pharmacological inhibitors of extracellular signal-regulated protein kinases attenuate the apoptotic action of cisplatin in human myeloid leukemia cells via glutathione-independent reduction in intracellular drug accumulation

Autor: M.A. Palacios, Adrian M. Ramos, Carlos Fernández, Elena de Blas, M. M. Gómez, Donna Amrán, Patricio Aller, Diego Esteban, Patricia Sancho

Publikováno v: E-Prints Complutense. Archivo Institucional de la UCM
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E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid

It has been reported that inhibition of extracellular signal-regulated protein kinases (ERKs) attenuates the toxicity cisplatin (cis-platinum (II)-diammine dichloride) in some cell types. This response was here investigated using human myeloid leukem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::692dad0a910c8fd63c48768aefb8df05
https://pubmed.ncbi.nlm.nih.gov/15843040

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12-O-tetradecanoylphorbol-13-acetate may both potentiate and decrease the generation of apoptosis by the antileukemic agent arsenic trioxide in human promonocytic cells. Regulation by extracellular signal-regulated protein kinases and glutathione

Autor: Carlos, Fernández, Adrián M, Ramos, Patricia, Sancho, Donna, Amrán, Elena, de Blas, Patricio, Aller

Publikováno v: The Journal of biological chemistry. 279(5)

Arsenic trioxide (As(2)O(3)) caused apoptosis in U-937 human promonocytic cells. This effect was potentiated by the simultaneous addition of the glutathione (GSH) synthesis inhibitor DL-buthionine-(R,S)-sulfoximine or the protein kinase C activators

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a700624bfec0cd6eed0d9bc0645de30e
https://pubmed.ncbi.nlm.nih.gov/14610070

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