Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Donmienne Leung"'
Autor:
Donmienne Leung, Jacqueline M. Wurst, Tao Liu, Ruben M. Martinez, Amita Datta-Mannan, Yiqing Feng
Publikováno v:
Antibodies, Vol 9, Iss 1, p 2 (2020)
Monoclonal antibodies have evolved from research tools to powerful therapeutics in the past 30 years. Clinical success rates of antibodies have exceeded expectations, resulting in heavy investment in biologics discovery and development in addition to
Externí odkaz:
https://doaj.org/article/fdfc6332ec064146af9777409f73155a
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2486 (2008)
Phosphoprotein phosphatase 2A (PP2A), a major serine-threonine protein phosphatase in eukaryotes, is an oligomeric protein comprised of structural (A) and catalytic (C) subunits to which a variable regulatory subunit (B) can associate. The C subunit
Externí odkaz:
https://doaj.org/article/cf65c887dd1a4115ba65804fc7d74f84
Autor:
Matthew Linnik, James Parker, Francisco Valenzuela, Michelle Swearingen, Purva Trivedi, Yiqing Feng, Seamus Brennan, Mark Castanares, Adam Mezo, Jianghuai Xu, Grace Chao, Michael Batt, Jude Onyia, Donmienne Leung
Immune-oncology therapies targeting adaptive immunity have transformed cancer therapy. In contrast, therapies targeting the innate immune response have received less attention. Here we describe an antibody drug conjugate (ADC) capable of engaging neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c39646c260c906023f154b0c67465398
https://doi.org/10.21203/rs.3.rs-2406517/v1
https://doi.org/10.21203/rs.3.rs-2406517/v1
Publikováno v:
The Journal of Immunology. 200:47.25-47.25
We recently demonstrated that PSGL-1 (P-selectin glycoprotein-1) could act as a T cell-intrinsic checkpoint inhibitor during chronic viral infection. As such, PSGL-1 may be a viable target to control T cell responses in the setting of autoimmune dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e7e7c0da852d9a1b70f3b4918fcf6b0
https://doi.org/10.4049/jimmunol.200.supp.47.25
https://doi.org/10.4049/jimmunol.200.supp.47.25
Publikováno v:
Biochemistry. 45:4720-4726
N-Acyl ethanolamines (NAEs) constitute a large and diverse class of signaling lipids that includes the endogenous cannabinoid anandamide. Like other lipid transmitters, NAEs are thought to be biosynthesized and degraded on-demand rather than being st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f5f919497192e442da8824c363d40bd
https://doi.org/10.1021/bi060163l
https://doi.org/10.1021/bi060163l
Publikováno v:
Nature Biotechnology. 21:687-691
To realize the promise of genomics-based therapeutics, new methods are needed to accelerate the discovery of small molecules that selectively modulate protein activity. Toward this end, advances in combinatorial synthesis have provided unprecedented
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ea4e59f4fa8c4c6922363fe36e3472
https://doi.org/10.1038/nbt826
https://doi.org/10.1038/nbt826
Publikováno v:
Journal of Medicinal Chemistry. 43:305-341
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4772be6495b20de970f8e842a346b73e
https://doi.org/10.1021/jm990412m
https://doi.org/10.1021/jm990412m
Publikováno v:
Letters in Peptide Science. 7:347-351
A new strategy has been developed for the rapid synthesis ofpeptide para-nitroanilides (pNA). The method involves derivatization of commercially available tritylchloride resin(TCP-resin) with 1,4-phenylenediamine, subsequent coupling withdesired amin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9cff069ebaf572e54945e8fe4652d37
https://doi.org/10.1023/a:1013016323676
https://doi.org/10.1023/a:1013016323676
Publikováno v:
Journal of General Virology. 80:1167-1177
The crystal structure coordinates of the hepatitis C virus NS3 protease (HCVpro) were used to develop an homology model of the dengue 2 virus NS3 protease (DEN2pro). The amino acid sequence of DEN2pro accommodates the same alpha-helices, beta-sheets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b871e5dd0626a3c411ec75ffb6688b0
https://doi.org/10.1099/0022-1317-80-5-1167
https://doi.org/10.1099/0022-1317-80-5-1167
Autor:
David J. Craik, Donmienne Leung, Dora M. Kovacs, G. Abbenante, David P. Fairlie, Rudolph E. Tanzi
Publikováno v:
Biochemical and Biophysical Research Communications. 268:133-135
A series of inhibitors of beta-amyloid formation have been developed based on the beta-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein. A simple tripeptide aldehyde was found to be the most potent (IC50 = 700 nM) in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931b0efadf7ef3f0c41f4a5931345628
https://doi.org/10.1006/bbrc.2000.2098
https://doi.org/10.1006/bbrc.2000.2098