Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

Autor: Zhang, F, Wei, K, Slowikowski, K, Fonseka, CY, Rao, DA, Kelly, S, Goodman, SM, Tabechian, D, Hughes, LB, Salomon-Escoto, K, Watts, GFM, Jonsson, AH, Rangel-Moreno, J, Meednu, N, Rozo, C, Apruzzese, W, Eisenhaure, TM, Lieb, DJ, Boyle, DL, Mandelin, AM, Albrecht, J, Bridges, SL, Buckley, CD, Buckner, JH, Dolan, J, Guthridge, JM, Gutierrez-Arcelus, M, Ivashkiv, LB, James, EA, James, JA, Keegan, J, Lee, YC, McGeachy, MJ, McNamara, MA, Mears, JR, Mizoguchi, F, Nguyen, JP, Noma, A, Orange, DE, Rohani-Pichavant, M, Ritchlin, C, Robinson, WH, Seshadri, A, Sutherby, D, Seifert, J, Turner, JD, Utz, PJ, Boyce, BF, Dicarlo, E, Gravallese, EM, Gregersen, PK, Moreland, L, Firestein, GS, Hacohen, N, Nusbaum, C, Lederer, JA, Perlman, H, Pitzalis, C, Filer, A, Holers, VM, Bykerk, VP, Donlin, LT, Anolik, JH, Brenner, MB, Raychaudhuri, S

Publikováno v: Nature immunology

To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing (RNA-seq) and flow cytometry to T cells, B cells, monocytes, and fibrobl

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Synovial fibroblast positional identity controlled by inductive Notch signaling underlies pathologic damage in inflammatory arthritis

Autor: Wei, K, Korsunsky, I, Marshall, JL, Gao, A, Watts, GFM, Major, T, Croft, AP, Watts, J, Blazar, P, Lange, J, Thornholl, T, Filer, A, Raza, K, Donlin, LT, Accelerating Medicines Partnership-Rheumatoid Arthritis/Systemic Lupus Erythematosus (Amp Ra/Sle), Siebel, CW, Buckley, C, Raychaudhuri, S, Brenner, MB

Publikováno v: Nature.

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Disrupting the RNA polymerase II transcription cycle through CDK7 inhibition ameliorates inflammatory arthritis.

Autor: Chen X; Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Medicine, New York, NY 10065, USA., Shibu G; Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Medicine, New York, NY 10065, USA., Sokolsky BA; Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Medicine, New York, NY 10065, USA., Soussana TN; Research Institute, Hospital for Special Surgery, New York, NY 10021, USA., Fisher L; Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Medicine, New York, NY 10065, USA., Deochand DK; Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10065, USA., Dacic M; Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; Physiology, Biophysics and Systems Biology Graduate Program, Weill Cornell Medicine, New York, NY 10065, USA., Mantel I; Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Medicine, New York, NY 10065, USA., Ramirez DC; Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY 10021, USA., Bell RD; Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; David Z. Rosensweig Genomics Center, Hospital for Special Surgery, New York, NY 10021, USA., Zhang T; Department of Chemical and Systems Biology, Chem-H and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA., Donlin LT; Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Medicine, New York, NY 10065, USA.; Physiology, Biophysics and Systems Biology Graduate Program, Weill Cornell Medicine, New York, NY 10065, USA., Goodman SM; Division of Rheumatology, Hospital for Special Surgery, New York, NY 10021, USA., Gray NS; Department of Chemical and Systems Biology, Chem-H and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA., Chinenov Y; Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; David Z. Rosensweig Genomics Center, Hospital for Special Surgery, New York, NY 10021, USA., Fisher RP; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10021, USA., Rogatsky I; Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Medicine, New York, NY 10065, USA.; David Z. Rosensweig Genomics Center, Hospital for Special Surgery, New York, NY 10021, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Nov 20; Vol. 16 (774), pp. eadq5091. Date of Electronic Publication: 2024 Nov 20.