A Targeted Metabolomics-Based Assay Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Identifies Structural and Functional Cardiotoxicity Potential

Autor: Jessica A. Palmer, Burrier Re, Jean-Pierre Valentin, Donley Elr, Gryshkova, Smith Am

Publikováno v: Toxicol Sci

Implementing screening assays that identify functional and structural cardiotoxicity earlier in the drug development pipeline has the potential to improve safety and decrease the cost and time required to bring new drugs to market. In this study, a m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cab5f4d2a8b73608b16b1e77a1caee2
https://pubmed.ncbi.nlm.nih.gov/32040181

A Metabolomics Approach to Screening for Autism Risk in the Children's Autism Metabolome Project.

Autor: Smith AM; Stemina Biomarker Discovery, Inc, Madison, Wisconsin, USA., Natowicz MR; Pathology and Laboratory Medicine, Genomics, Neurology, and Pediatrics Institutes, Cleveland Clinic, Cleveland, Ohio, USA., Braas D; Stemina Biomarker Discovery, Inc, Madison, Wisconsin, USA., Ludwig MA; Stemina Biomarker Discovery, Inc, Madison, Wisconsin, USA., Ney DM; Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA., Donley ELR; Stemina Biomarker Discovery, Inc, Madison, Wisconsin, USA., Burrier RE; Stemina Biomarker Discovery, Inc, Madison, Wisconsin, USA., Amaral DG; The MIND Institute and Department of Psychiatry and Behavioral Sciences, University of California Davis, Davis, California, USA.

Publikováno v: Autism research : official journal of the International Society for Autism Research [Autism Res] 2020 Aug; Vol. 13 (8), pp. 1270-1285. Date of Electronic Publication: 2020 Jun 18.

Reply to: Lack of Diagnostic Utility of "Amino Acid Dysregulation Metabotypes".

Autor: Smith AM; Stemina Biomarker Discovery, Inc., Madison, Wisconsin., Donley ELR; Stemina Biomarker Discovery, Inc., Madison, Wisconsin., Burrier RE; Stemina Biomarker Discovery, Inc., Madison, Wisconsin., King JJ; Stemina Biomarker Discovery, Inc., Madison, Wisconsin., Amaral DG; Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California, Davis, Davis, California; Department of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, California. Electronic address: dgamaral@ucdavis.edu.

Publikováno v: Biological psychiatry [Biol Psychiatry] 2019 Apr 01; Vol. 85 (7), pp. e43-e44. Date of Electronic Publication: 2018 Dec 27.

A human induced pluripotent stem cell-based in vitro assay predicts developmental toxicity through a retinoic acid receptor-mediated pathway for a series of related retinoid analogues.

Autor: Palmer JA; Stemina Biomarker Discovery, Inc., 504 S. Rosa Rd., Madison, WI 53719, USA. Electronic address: jpalmer@stemina.com., Smith AM; Stemina Biomarker Discovery, Inc., 504 S. Rosa Rd., Madison, WI 53719, USA. Electronic address: asmith@stemina.com., Egnash LA; Stemina Biomarker Discovery, Inc., 504 S. Rosa Rd., Madison, WI 53719, USA. Electronic address: laura.egnash@covance.com., Colwell MR; Stemina Biomarker Discovery, Inc., 504 S. Rosa Rd., Madison, WI 53719, USA. Electronic address: mcolwell@stemina.com., Donley ELR; Stemina Biomarker Discovery, Inc., 504 S. Rosa Rd., Madison, WI 53719, USA. Electronic address: bdonley@stemina.com., Kirchner FR; Stemina Biomarker Discovery, Inc., 504 S. Rosa Rd., Madison, WI 53719, USA. Electronic address: fkirchner@stemina.com., Burrier RE; Stemina Biomarker Discovery, Inc., 504 S. Rosa Rd., Madison, WI 53719, USA. Electronic address: bburrier@stemina.com.

Publikováno v: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2017 Oct; Vol. 73, pp. 350-361. Date of Electronic Publication: 2017 Jul 23.