Výsledky vyhledávání - "Donita C. Brady"

Akademický článek

IGF2BP1/IMP1 Deletion Enhances a Facultative Stem Cell State via Regulation of MAP1LC3BSummary

Autor: Louis R. Parham, Patrick A. Williams, Kay Katada, Shaneice K. Nettleford, Priya Chatterji, Kofi K. Acheampong, Charles H. Danan, Xianghui Ma, Lauren A. Simon, Kaitlyn E. Naughton, Rei Mizuno, Tatiana Karakasheva, Emily A. McMillan, Kelly A. Whelan, Donita C. Brady, Sydney M. Shaffer, Kathryn E. Hamilton

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 3, Pp 439-451 (2024)

Background & Aims: The intestinal epithelium interfaces with a diverse milieu of luminal contents while maintaining robust digestive and barrier functions. Facultative intestinal stem cells are cells that survive tissue injury and divide to re-establ

Externí odkaz: https://doaj.org/article/2d55833f363e489b8c29b533990b04ea

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Akademický článek

Copper Modulates the Catalytic Activity of Protein Kinase CK2

Autor: John E. Chojnowski, Rongrong Li, Tiffany Tsang, Fatimah H. Alfaran, Alexej Dick, Simon Cocklin, Donita C. Brady, Todd I. Strochlic

Publikováno v: Frontiers in Molecular Biosciences, Vol 9 (2022)

Casein kinase 2 (CK2) is an evolutionarily conserved serine/threonine kinase implicated in a wide range of cellular functions and known to be dysregulated in various diseases such as cancer. Compared to most other kinases, CK2 exhibits several unusua

Externí odkaz: https://doaj.org/article/ccfe4ca0b5f74d71a73a5392371c6c1c

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Akademický článek

Direct anabolic metabolism of three-carbon propionate to a six-carbon metabolite occurs in vivo across tissues and species

Autor: Mary T. Doan, Michael D. Neinast, Erika L. Varner, Kenneth C. Bedi, Jr., David Bartee, Helen Jiang, Sophie Trefely, Peining Xu, Jay P. Singh, Cholsoon Jang, J. Eduardo Rame, Donita C. Brady, Jordan L. Meier, Kenneth B. Marguiles, Zoltan Arany, Nathaniel W. Snyder

Publikováno v: Journal of Lipid Research, Vol 63, Iss 6, Pp 100224- (2022)

Anabolic metabolism of carbon in mammals is mediated via the one- and two-carbon carriers S-adenosyl methionine and acetyl-coenzyme A. In contrast, anabolic metabolism of three-carbon units via propionate has not been shown to extensively occur. Mamm

Externí odkaz: https://doaj.org/article/37582cdc3e554e4a95aee9b775a2c9c9

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Akademický článek

Loss of p19Arf promotes fibroblast survival during leucine deprivation

Autor: Kerry C. Roby, Allyson Lieberman, Bang-Jin Kim, Nicole Zaragoza Rodríguez, Jessica M. Posimo, Tiffany Tsang, Ioannis I. Verginadis, Ellen Puré, Donita C. Brady, Constantinos Koumenis, Sandra Ryeom

Publikováno v: Biology Open, Vol 11, Iss 2 (2022)

Fibroblasts are quiescent and tumor suppressive in nature but become activated in wound healing and cancer. The response of fibroblasts to cellular stress has not been extensively investigated, however the p53 tumor suppressor has been shown to be ac

Externí odkaz: https://doaj.org/article/2d75c0195d6f44f185ece86f67e5048f

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Akademický článek

Understanding and drugging RAS: 40 years to break the tip of the iceberg

Autor: Donita C. Brady, Julija Hmeljak, Arvin C. Dar

Publikováno v: Disease Models & Mechanisms, Vol 15, Iss 2 (2022)

Several cancers and rare genetic diseases are caused by dysregulation in the RAS signaling pathway. RAS proteins serve as molecular switches that regulate pathways involved in cellular growth, differentiation and survival. These pathways have been an

Externí odkaz: https://doaj.org/article/e5c5cbfd2dc74fa28ae659cffcd069fe

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