Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Dongzhi Ran"'
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2512-2529 (2022)
Simultaneous inhibition of histone deacetylases (HDACs) and anaplastic lymphoma kinase (ALK) could enhance therapeutic activity against ALK addicted cancer cells. Herein, a new series of 2,4-pyrimidinediamine derivatives as ALK and HDACs dual inhibit
Externí odkaz:
https://doaj.org/article/71b55731c97b44d4b874f53ec9623f18
Autor:
Xue Cao, Wenjuan Li, Ting Wang, Dongzhi Ran, Veronica Davalos, Laura Planas-Serra, Aurora Pujol, Manel Esteller, Xiaolin Wang, Huichuan Yu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-7 (2022)
Age is a risk factor for SARS-CoV-2 infection and severe disease. Here the authors perform DNA methylation analyses in whole blood from COVID-19 patients using established epigenetic clocks and telomere length estimators, and describing correlations
Externí odkaz:
https://doaj.org/article/97acfc4c384c4360952817d52f07ed50
Autor:
Santiago I. Loya-López, Paz Duran, Dongzhi Ran, Aida Calderon-Rivera, Kimberly Gomez, Aubin Moutal, Rajesh Khanna
Publikováno v:
Neurobiology of Pain, Vol 12, Iss , Pp 100109- (2022)
The voltage-gated sodium NaV1.7 channel sets the threshold for electrogenesis. Mutations in the gene encoding human NaV1.7 (SCN9A) cause painful neuropathies or pain insensitivity. In dorsal root ganglion (DRG) neurons, activity and trafficking of Na
Externí odkaz:
https://doaj.org/article/a9a696a84f284dbf8f3cba3f123aad63
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-11 (2021)
Abstract Voltage-gated sodium channels are key players in neuronal excitability and pain signaling. Functional expression of the voltage-gated sodium channel NaV1.7 is under the control of SUMOylated collapsin response mediator protein 2 (CRMP2). Whe
Externí odkaz:
https://doaj.org/article/8b9e30711e1d4322957af6878601721d
Autor:
Yi Lu, Hong Wang, Junqing Yang, Wengao Jiang, Hong Xin, Ying Luo, Santiago Loya-López, Huaiyu Gu, Dongzhi Ran
Publikováno v:
Molecules, Vol 27, Iss 10, p 3082 (2022)
Mono-(2-ethylhexyl) phthalate (MEHP) is one of the main active metabolites of di-(2-ethylhexyl) phthalate (DEHP). In our previous works, by using rat and Drosophila models, we showed a disruption of neural function due to DEHP. However, the exact neu
Externí odkaz:
https://doaj.org/article/2e91d76294b14020a3c24f0126ef9696
Autor:
Miaomiao Li, Junqing Yang, Oumei Cheng, Zhe Peng, Yin Luo, Dongzhi Ran, Yang Yang, Pu Xiang, Haifeng Huang, Xiaodan Tan, Hong Wang
Publikováno v:
Therapeutic Advances in Chronic Disease, Vol 12 (2021)
Background: Human bone marrow mesenchymal stem cells (hBMSCs) could differentiate into dopamine-producing cells and ameliorate behavioral deficits in Parkinson’s disease (PD) models. Liver X receptors (LXRs) are involved in the maintenance of the n
Externí odkaz:
https://doaj.org/article/c063b6f074a645c6865aae7ca7d745c7
Autor:
Lu Yang, Wenli Han, Ying Luo, Xiangnan Hu, Ying Xu, Huan Li, Congli Hu, Dan Huang, Jie Ma, Yang Yang, Qi Chen, Yuke Li, Jiahua Zhang, Hui Xia, Zhihao Chen, Hong Wang, Dongzhi Ran, Junqing Yang
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Our previous studies indicated that adapentpronitrile, a new adamantane-based dipeptidyl peptidase-IV (DPP-IV) inhibitor, has a hypoglycemic effect and ameliorates rat pancreatic β cell dysfunction in type 2 diabetes mellitus through inhibiting DPP-
Externí odkaz:
https://doaj.org/article/0a8ae17dec9f4f8a8b31a135d6fd6c7e
Autor:
Paz Duran, Santiago Loya‐López, Dongzhi Ran, Cheng Tang, Aida Calderon‐Rivera, Kimberly Gomez, Harrison J. Stratton, Sun Huang, Ya‐ming Xu, E. M. Kithsiri Wijeratne, Samantha Perez‐Miller, Zhiming Shan, Song Cai, Anna T. Gabrielsen, Angie Dorame, Kyleigh A. Masterson, Omar Alsbiei, Cynthia L. Madura, Guoqin Luo, Aubin Moutal, John Streicher, Gerald W. Zamponi, A. A. Leslie Gunatilaka, Rajesh Khanna
Publikováno v:
British Journal of Pharmacology. 180:1267-1285
Postoperative pain occurs in as many as 70% of the over 230 million surgeries performed annually worldwide. Postoperative pain management still relies on opioids despite their negative consequences, resulting in a public health crisis. Therefore, it
Autor:
Jing, Huang, Yibei, Zhao, Yanni, Cao, Qingxia, Zhang, Dongzhi, Ran, Jinyan, Li, Ling, Luo, Feng, Qiu, Long, Meng
Publikováno v:
International Journal of Clinical Pharmacy. 44:993-1003
BACKGROUND : There have been cases reporting anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) and associated serious gastrointestinal (GI) adverse drug reactions (gastrointestinal obstruction, perforation, and ulceration). These adv
Autor:
Kimberly Gomez, Cheng Tang, Bin Tan, Samantha Perez-Miller, Dongzhi Ran, Santiago Loya, Aida Calderon-Rivera, Harrison J. Stratton, Paz Duran, Kyleigh A. Masterson, Anna T. Gabrielsen, Omar Alsbiei, Angie Dorame, Maria Serafini, Aubin Moutal, Jun Wang, Rajesh Khanna
Publikováno v:
ACS Chemical Neuroscience. 13:2035-2047