Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Dongzhao Chen"'
Autor:
Graham Elgin Jones, Alan Joseph Hennessy, Steve Rittenhouse, Ilaria Giordano, Roger Edward Markwell, Steven Dabbs, Michael N. Gwynn, David T. Davies, Jennifer Hoover, Nathalie Cailleau, Barry S. Brown, Joel Michael Esken, Neil D. Pearson, Pamela Brown, Dongzhao Chen, Elisabeth A. Minthorn, Ben Bax, Gerald Brooks, Timothy J. Miles, Senthill K. Kusalakumari Sukmar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2464-2469
During the course of our research on the lead optimisation of the NBTI (Novel Bacterial Type II Topoisomerase Inhibitors) class of antibacterials, we discovered a series of tricyclic compounds that showed good Gram-positive and Gram-negative potency.
Autor:
Thomas Germe, Eric Bacqué, Lynn McCloskey, Kaushik Raha, Haifeng Cui, Anthony Maxwell, Benjamin D. Bax, Reema K. Thalji, Anna Checchia, Dongzhao Chen, Pan F. Chan, Jianzhong Huang, Xiao Ding, Robert A. Stavenger, Velupillai Srikannathasan, Karen A. Ingraham
A paucity of novel acting antibacterials is in development to treat the rising threat of antimicrobial resistance, particularly in Gram-negative hospital pathogens, which has led to renewed efforts in antibiotic drug discovery. Fluoroquinolones are b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0743e12fca822d94a4442ee838e3412
https://doi.org/10.1073/pnas.1700721114
https://doi.org/10.1073/pnas.1700721114
Autor:
Aubart Kelly M, Karen O'Dwyer, Dongzhao Chen, Thomas Lewandowski, Magdalena Zalacain, D. L. Butler
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:290-296
Peptide deformylase (PDF), a clinically unexploited antibacterial target, plays an essential role in protein maturation. PDF inhibitors, therefore, represent a new antibiotic class with a unique mode of action that provides an alternative therapy for
Autor:
Pamela Brown, Roger Edward Markwell, David L. Downie, Susanne Eyrisch, Neil D. Pearson, Dongzhao Chen, Christopher Barfoot, Stephen Rittenhouse, Graham Elgin Jones, Mark A. Seefeld, Elizabeth A. Minthorn, Jeffrey M. Axten, Steven Dabbs, Alan Joseph Hennessy, Michael N. Gwynn, Gerald Brooks, Jianzhong Huang, Ilaria Giordano, William H. Miller, David T. Davies, Timothy Francis Gallagher, Timothy J. Miles, Jennifer Hoover
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:7489-7495
We have identified a series of amino-piperidine antibacterials with a good broad spectrum potency. We report the investigation of various subunits in this series and advanced studies on compound 8. Compound 8 possesses good pharmacokinetics, broad sp
Autor:
Stephen Rittenhouse, Neil D. Pearson, Christopher Barfoot, Graham Elgin Jones, Timothy J. Miles, David L. Downie, Dongzhao Chen, Steven Dabbs, Jennifer Hoover, Roger Edward Markwell, Alan Joseph Hennessy, Jianzhong Huang, Michael N. Gwynn, Ilaria Giordano, Gerald Brooks, Hong Xiang, David T. Davies, Susanne Eyrisch, Pamela Brown
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:7483-7488
As part of our wider efforts to exploit novel mode of action antibacterials, we have discovered a series of cyclohexyl-amide compounds that has good Gram positive and Gram negative potency. The mechanism of action is via inhibition of bacterial topoi
Autor:
Xiaokan Wang, Dongzhao Chen
Publikováno v:
Advances in Computer Science Research.
Autor:
Cindy Richards, Stephen Rittenhouse, Daniel R. Gentry, Dongzhao Chen, Susan Neill, Magdalena Zalacain, Katja Remlinger, Michael N. Gwynn, Imogen E. Wilding, John Johnson
Publikováno v:
Journal of Microbiological Methods. 83:254-256
We developed a homogenous microtiter based assay using the cationic dye 3, 3'-Diethyloxacarbocyanine iodide, DiOC2(3), to measure the effect of compounds on membrane potential in Staphylococcus aureus. In a screen of 372 compounds from a synthetic co
Autor:
Marcin Filutowicz, Marjeta Urh, Jin Feng, Ross B. Inman, Ricardo Henrique Krüger, Dongzhao Chen
Publikováno v:
Journal of Molecular Biology. 282:775-787
The regulation of the plasmid R6K γ origin (γ ori ) is accomplished through the ability of the π protein to act as an initiator and inhibitor of replication. Hyperactive variants of this protein, called copy-up π, allow four to tenfold increases
Autor:
Chan, Pan F., Germe, Thomas, Bax, Benjamin D., Jianzhong Huang, Thalji, Reema K., Bacqué, Eric, Checchia, Anna, Dongzhao Chen, Haifeng Cui, Xiao Ding, Ingraham, Karen, McCloskey, Lynn, Raha, Kaushik, Srikannathasan, Velupillai, Maxwell, Anthony, Stavenger, Robert A.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 5/30/2017, Vol. 114 Issue 22, pE4492-E4500, 9p
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 94(25)
The pir gene of plasmid R6K encodes the protein, π, a replication and transcription factor. Two translational options for the pir gene give rise to two forms of π protein: a 35.0-kDa form (π 35.0 ) and a shortened 30.5-kDa form (π 30.5 ). Althoug