Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Dongyu Sheng"'
Autor:
Kang Qian, Peng Yang, Yixian Li, Ran Meng, Yunlong Cheng, Lingling Zhou, Jing Wu, Shuting Xu, Xiaoyan Bao, Qian Guo, Pengzhen Wang, Minjun Xu, Dongyu Sheng, Qizhi Zhang
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 19, Iss 4, Pp 100938- (2024)
Alzheimer's disease is a neurodegenerative disease induced by multiple interconnected mechanisms. Peptide drug candidates with multi-modal efficacy generated from fusion strategy are suitable for addressing multi-facet pathology. However, clinical tr
Externí odkaz:
https://doaj.org/article/403f74994e394d2e9ed2d13b852fc61f
Autor:
Yixian Li, Peng Yang, Ran Meng, Shuting Xu, Lingling Zhou, Kang Qian, Pengzhen Wang, Yunlong Cheng, Dongyu Sheng, Minjun Xu, Tianying Wang, Jing Wu, Jinxu Cao, Qizhi Zhang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 3, Pp 1380-1399 (2024)
Intraneuronal dysproteostasis and extraneuronal microenvironmental abnormalities in Alzheimer's disease (AD) collectively culminate in neuronal deterioration. In the context of AD, autophagy dysfunction, a multi-link obstacle involving autophagy down
Externí odkaz:
https://doaj.org/article/8bd04ee938174169b40471e454fdf68d
Autor:
Qian Guo, Xiaoyao Zheng, Peng Yang, Xiaoying Pang, Kang Qian, Pengzhen Wang, Shuting Xu, Dongyu Sheng, Liuchang Wang, Jinxu Cao, Wei Lu, Qizhi Zhang, Xinguo Jiang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 9, Iss 3, Pp 590-603 (2019)
Gene therapy represents a promising treatment for the Alzheimer׳s disease (AD). However, gene delivery specific to brain lesions through systemic administration remains big challenge. In our previous work, we have developed an siRNA nanocomplex able
Externí odkaz:
https://doaj.org/article/bb849093345041d0b3fd7ec9bb9ad94e
Autor:
Qian Guo, Yixian Li, Shuting Xu, Pengzhen Wang, Kang Qian, Peng Yang, Dongyu Sheng, Liuchang Wang, Yunlong Cheng, Ran Meng, Jinxu Cao, Haichang Luo, Yan Wei, Qizhi Zhang
Publikováno v:
Journal of Controlled Release. 355:604-621
Autor:
Yunlong Cheng, Xiaoying Pang, Jing Wu, Lingling Zhou, Jinxu Cao, Liuchang Wang, Kang Qian, Peng Yang, Minjun Xu, Dongyu Sheng, Ran Meng, Pengzhen Wang, Qian Guo, Shuting Xu, Yan Wei, Qizhi Zhang
Publikováno v:
Drug Delivery and Translational Research.
Autor:
Kang Qian, Xiaoyan Bao, Yixian Li, Pengzhen Wang, Qian Guo, Peng Yang, Shuting Xu, Fazhi Yu, Ran Meng, Yunlong Cheng, Dongyu Sheng, Jinxu Cao, Minjun Xu, Jing Wu, Tianying Wang, Yonghui Wang, Qiong Xie, Wei Lu, Qizhi Zhang
Publikováno v:
ACS nano. 16(7)
Mitochondrial dysfunction in neurons has recently become a promising therapeutic target for Alzheimer's disease (AD). Regulation of dysfunctional mitochondria through multiple pathways rather than antioxidation monotherapy indicates synergistic thera
Autor:
Kang Qian, Dongyu Sheng, Jinxu Cao, Qian Guo, Qizhi Zhang, Peng Yang, Shuting Xu, Shuai Lu, Pengzhen Wang, Wei Lu
Publikováno v:
Journal of Controlled Release. 320:347-362
The presence of blood-brain barrier (BBB) and specificity of neuron targeting remain two challenges in the effective delivery of nanotherapeutics for the treatment of Alzheimers disease (AD). Traditional strategy of nanocarriers for AD treatment invo
Autor:
Xiaoying Pang, Dongyu Sheng, Xu Wan, Qian Guo, Kang Qian, Jingxu Cao, Qizhi Zhang, Liuchang Wang, Yunlong Cheng, Peng Yang, Xinguo Jiang
Publikováno v:
Journal of Drug Delivery Science and Technology. 52:997-1007
Gefitinib, a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, has showed remarkable activity in non-small cell lung cancer patients with tumors carrying sensitive EGFR mutation. However, Iressa® tablets present problems,
Autor:
Xinguo Jiang, Dongyu Sheng, Kang Qian, Jinxu Cao, Wei Lu, Qian Guo, Liuchang Wang, Pengzhen Wang, Xiaoyao Zheng, Xiaoying Pang, Qizhi Zhang, Shuting Xu, Peng Yang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 9, Iss 3, Pp 590-603 (2019)
Gene therapy represents a promising treatment for the Alzheimer׳s disease (AD). However, gene delivery specific to brain lesions through systemic administration remains big challenge. In our previous work, we have developed an siRNA nanocomplex able
Autor:
Liuchang Wang, Dongyu Sheng, Yunlong Cheng, Qizhi Zhang, Pengzhen Wang, Qian Guo, Peng Yang, Yixian Li, Wei Lu, Kang Qian, Shuting Xu
Publikováno v:
Biomaterials. 238
Mitochondrial dysfunction is an early event of Alzheimer's disease (AD), contributes the onset and progression of AD, and may represent an effective therapeutic target for AD intervention. Since mitochondria in central neurons are more susceptible to