Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Dongying Gu"'
Autor:
Junyi Xin, Dongying Gu, Shuwei Li, Sangni Qian, Yifei Cheng, Wei Shao, Shuai Ben, Silu Chen, Linjun Zhu, Mingjuan Jin, Kun Chen, Zhibin Hu, Zhengdong Zhang, Mulong Du, Hongbing Shen, Meilin Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The development of an effective survival prediction tool is key for reducing colorectal cancer mortality. Here, we apply a three-stage study to devise a polygenic prognostic score (PPS) for stratifying colorectal cancer overall survival. Lev
Externí odkaz:
https://doaj.org/article/6db6afb6970c45f99728d2f159855d96
Autor:
Mengfan Guo, Shuwei Li, Yifei Cheng, Junyi Xin, Jieyu Zhou, Shenya Xu, Shuai Ben, Meilin Wang, Zhengdong Zhang, Dongying Gu
Publikováno v:
Environment International, Vol 190, Iss , Pp 108924- (2024)
Exposure to persistent organic pollutants (POPs) may contribute to colorectal cancer risk, but the underlying mechanisms of crucial POPs exposure remain unclear. Hence, we systematically investigated the associations among POPs exposure, genetics and
Externí odkaz:
https://doaj.org/article/0b80dbceb8fe421fb09c53df6011c6c7
Autor:
Shuai Ben, Shuwei Li, Dongying Gu, Lingyan Zhao, Shenya Xu, Zhutao Ding, Silu Chen, Yifei Cheng, Junyi Xin, Mulong Du, Meilin Wang
Publikováno v:
Environment International, Vol 184, Iss , Pp 108443- (2024)
Environmental pollutants known as polycyclic aromatic hydrocarbons (PAHs) are produced through the incomplete combustion of organic material. While PAHs have been investigated as genotoxicants, they can also operate through nongenotoxic pathways in e
Externí odkaz:
https://doaj.org/article/80def14d62bd468990533e9cb524404d
Publikováno v:
Cancer Medicine, Vol 12, Iss 2, Pp 1376-1388 (2023)
Abstract Background Colorectal cancer is one of the most common malignant digestive tract tumors with a poor prognosis. RNA 5‐methylcytosine (m5C) is an important posttranscriptional widespread modification involved in many biological processes. Ho
Externí odkaz:
https://doaj.org/article/9df89e3dd2714845830caa67bb78a518
Autor:
Junyi Xin, Mulong Du, Dongying Gu, Kewei Jiang, Mengyun Wang, Mingjuan Jin, Yeting Hu, Shuai Ben, Silu Chen, Wei Shao, Shuwei Li, Haiyan Chu, Linjun Zhu, Chen Li, Kun Chen, Kefeng Ding, Zhengdong Zhang, Hongbing Shen, Meilin Wang
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Background The genetic architectures of colorectal cancer are distinct across different populations. To date, the majority of polygenic risk scores (PRSs) are derived from European (EUR) populations, which limits their accurate extrapolation
Externí odkaz:
https://doaj.org/article/7d08ab44d2ae4b52b6212ff1bad5e83b
Autor:
Junyi Xin, Xia Jiang, Huiqin Li, Silu Chen, Zhengdong Zhang, Meilin Wang, Dongying Gu, Mulong Du, David C. Christiani
Publikováno v:
EBioMedicine, Vol 89, Iss , Pp 104454- (2023)
Summary: Background: Polygenic risk score (PRS) has been demonstrated to be effective in identifying individuals at high risk of developing cancer, but its prognostic value remains unclear. Methods: We constructed site-specific PRSs by aggregating th
Externí odkaz:
https://doaj.org/article/7bb75bf728a94965bc46fa5a780c91e9
Autor:
Rui Zheng, Ke Zhang, Shanyue Tan, Fang Gao, Yajie Zhang, Wenxia Xu, Huabin Wang, Dongying Gu, Lingjun Zhu, Shuwei Li, Haiyan Chu, Zhengdong Zhang, Lingxiang Liu, Mulong Du, Meilin Wang
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-14 (2022)
Abstract Background Exosomes have emerged as vital biomarkers of multiple cancers and contain abundant circular RNAs (circRNAs). However, the potential for exosomal circRNAs to be used in diagnostics and their molecular mechanism of action in colorec
Externí odkaz:
https://doaj.org/article/4e86c1381a6f42fabfd9c0de4c867702
Autor:
Shuwei Li, Silu Chen, Qiuyuan Zhu, Shuai Ben, Fang Gao, Junyi Xin, Mulong Du, Haiyan Chu, Dongying Gu, Zhengdong Zhang, Meilin Wang
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 7, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/c00e00dcacef4280b88961e747b4e33c
Autor:
Huiyan Wang, Dongying Gu, Miao Yu, Yanjun Hu, Zhe Chen, Xinying Huo, Tao Yu, Jinfei Chen, Yang Zheng
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021)
Abstract Backgrounds Genome-wide association studies (GWAS) have identified multiple common CRC-related (colorectal cancer) SNPs (single nucleotide polymorphisms) including the Cadherin 1(CDH1) rs9929218 may act by increasing the risk of colorectal c
Externí odkaz:
https://doaj.org/article/b4873416639343049c0b804d920b2b12
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
BackgroundIt is estimated that 35% of gastric cancer patients appear with synchronous distant metastases—the vast majority of patients presenting with metastatic hepatic disease. How to choose the most appropriate drugs or regimens is crucial to im
Externí odkaz:
https://doaj.org/article/be684377ca394ba38ef73107e320055b