Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Dongweon Song"'
Autor:
Sanela Tarabar, Debra Kelsh, Bradley Vince, Rina Leyva, Dongweon Song, Kyle Matschke, David E. Kellstein, Suzanne Meeves, Mario Cruz-Rivera
Publikováno v:
Drugs in R&D, Vol 20, Iss 1, Pp 23-37 (2020)
Abstract Introduction A fixed-dose combination (FDC) of ibuprofen and acetaminophen has been developed that provides greater analgesic efficacy than either agent alone at the same doses without increasing the risk for adverse events. Methods We repor
Externí odkaz:
https://doaj.org/article/ffd5f1abe8a9407585b18ff53cbc6a95
Autor:
Colin D. Weekes, Dongweon Song, John Arcaroli, Lora A. Wilson, Belen Rubio-Viqueira, George Cusatis, Elizabeth Garrett-Mayer, Wells A. Messersmith, Robert A. Winn, Manuel Hidalgo
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 8, Pp 690-701 (2012)
PURPOSE: The factors preventing the translation of preclinical findings supporting the clinical development mTOR-targeted therapy in pancreatic cancer therapy remain undetermined. Stromal cell.derived factor 1α (SDF-1α)-CXCR4 signaling was examined
Externí odkaz:
https://doaj.org/article/aba201eee29846aebff0ad9a9f9563f3
Autor:
Manuel Hidalgo, Akhilesh Pandey, Antonio Jimeno, Christian Fritz, Margaret Read, Jeffrey Tong, Anna Solomon, Xian Feng Zhang, Fernando López-Ríos, Ana Suárez-Gauthier, Anuradha Nalli, Elena García-García, Aik Choon Tan, Raghothama Chaerkady, Dongweon Song
Targeting Hsp90 is an attractive strategy for anticancer therapy because the diversity and relevance of biological processes are regulated by these proteins in most cancers. However, the role and mode of action of Hsp90 inhibitors in pancreatic cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0690c76d61d810f28385d6a95183ba00
https://doi.org/10.1158/1535-7163.c.6531134.v1
https://doi.org/10.1158/1535-7163.c.6531134.v1
Autor:
Manuel Hidalgo, Akhilesh Pandey, Antonio Jimeno, Christian Fritz, Margaret Read, Jeffrey Tong, Anna Solomon, Xian Feng Zhang, Fernando López-Ríos, Ana Suárez-Gauthier, Anuradha Nalli, Elena García-García, Aik Choon Tan, Raghothama Chaerkady, Dongweon Song
Supplementary Table S6 from Antitumor activity and molecular effects of the novel heat shock protein 90 inhibitor, IPI-504, in pancreatic cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619f7f2d5c224b9d7ea68bd8b77e19b9
https://doi.org/10.1158/1535-7163.22483400.v1
https://doi.org/10.1158/1535-7163.22483400.v1
Autor:
Kyle Matschke, Sanela Tarabar, Mario Cruz-Rivera, David Kellstein, Debra Kelsh, Bradley Vince, Suzanne Meeves, Dongweon Song, Rina Leyva
Publikováno v:
Drugs in R&D
Drugs in R&D, Vol 20, Iss 1, Pp 23-37 (2020)
Drugs in R&D, Vol 20, Iss 1, Pp 23-37 (2020)
Introduction A fixed-dose combination (FDC) of ibuprofen and acetaminophen has been developed that provides greater analgesic efficacy than either agent alone at the same doses without increasing the risk for adverse events. Methods We report three c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4bfe71fd10fcdd436fba4782b68d3d
https://pubmed.ncbi.nlm.nih.gov/32130679
https://pubmed.ncbi.nlm.nih.gov/32130679
Publikováno v:
The Journal of Clinical Pharmacology. 56:559-566
Ceritinib is a potent inhibitor of anaplastic lymphoma kinase (ALK), which has shown acceptable safety and substantial antitumor activity in ALK-positive non-small cell lung cancer (NSCLC) patients. Two food-effect studies were conducted in healthy a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3938ed1b154dfc069e11177d95a314fc
https://doi.org/10.1002/jcph.619
https://doi.org/10.1002/jcph.619
Autor:
Astrid Breitschaft, Pierre Jordaan, Dongweon Song, Ke Hu, Michelle Hudson, Rashmi Shah, Christelle Darstein, Monica Ligueros-Saylan
Publikováno v:
Journal of Clinical Pharmacology
The aim of this study was to evaluate the effects of subcutaneous pasireotide on cardiac repolarization in healthy volunteers. Healthy volunteers were randomized to one of four treatment sequences (n = 112) involving four successive treatments in dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2c766df5349ca195e8cd47b59b4766
https://doi.org/10.1002/jcph.213
https://doi.org/10.1002/jcph.213
Autor:
Ke Hu, Douglas M. Heuman, Dago Mazur, Frans-Peter Botha, Matthieu Ruffin, Yanfeng Wang, Dongweon Song, Yves Horsmans, Ying Wang, Emmanuel Bouillaud
Publikováno v:
The Journal of Clinical Pharmacology. 52:552-558
Pasireotide is a novel, multireceptor-targeted somatostatin analogue with high affinity for sst(1,2,3) and sst(5) under clinical evaluation in tumors of neuroendocrine origin, including Cushing's disease, acromegaly, and neuroendocrine tumors. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b0f3bce9d3875019200c0ef9a9dbe5
https://doi.org/10.1177/0091270011400072
https://doi.org/10.1177/0091270011400072
Autor:
Hartmut Dietrich, Emmanuel Bouillaud, Ke Hu, Matthieu Ruffin, Yanfeng Wang, Jens Hasskarl, Dongweon Song
Publikováno v:
European Journal of Endocrinology. 166:821-828
Objective: This study was conducted to evaluate the safety, tolerability, and pharmacokinetics (PKs) of different doses of a long-acting release (LAR) formulation of pasireotide in healthy subjects. Design: Single-center, open-label, randomized Phase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34fd7f6b2163ebee89f22502d0a9e04
https://doi.org/10.1530/eje-11-0773
https://doi.org/10.1530/eje-11-0773
Autor:
Ming Zhao, Antonio Jimeno, Preeti Shah, Michelle A. Rudek, Howard Goldsweig, Daniel A. Laheru, Gretchen E. Taylor, Florencia McAllister, N. V. Rajeshkumar, Sheila Linden, Dongweon Song, Ross C. Donehower, Dung T. Le, Manuel Hidalgo
Purpose S-trans,trans-Farnesylthiosalicylic Acid (FTS, salirasib) inhibits Ras-dependent cell growth by dislodging all isoforms of Ras, including mutant Ras, from the plasma membrane. This study evaluated the activity, safety, and toxicity of saliras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff8eb183a5d4fb869d54a8f122246e61
https://europepmc.org/articles/PMC3557459/
https://europepmc.org/articles/PMC3557459/