Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Dongwen Lv"'
Autor:
Digant Nayak, Dongwen Lv, Yaxia Yuan, Peiyi Zhang, Wanyi Hu, Anindita Nayak, Eliza A. Ruben, Zongyang Lv, Patrick Sung, Robert Hromas, Guangrong Zheng, Daohong Zhou, Shaun K. Olsen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Overexpression of BCL-xL and BCL-2 play key roles in tumorigenesis and cancer drug resistance. Advances in PROTAC technology facilitated recent development of the first BCL-xL/BCL-2 dual degrader, 753b, a VHL-based degrader with improved pot
Externí odkaz:
https://doaj.org/article/4bf39db45fce4580a5d76e6623bf229c
Autor:
Dongwen Lv, Pratik Pal, Xingui Liu, Yannan Jia, Dinesh Thummuri, Peiyi Zhang, Wanyi Hu, Jing Pei, Qi Zhang, Shuo Zhou, Sajid Khan, Xuan Zhang, Nan Hua, Qingping Yang, Sebastian Arango, Weizhou Zhang, Digant Nayak, Shaun K. Olsen, Susan T. Weintraub, Robert Hromas, Marina Konopleva, Yaxia Yuan, Guangrong Zheng, Daohong Zhou
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Simultaneous targeting of BCL-xL and BCL-2 is an attractive approach for cancer treatment. Based on information gained by computational structure modelling, the authors develop a PROTAC that induces degradation of both BCL-xL and BCL-2 and effectivel
Externí odkaz:
https://doaj.org/article/38d97353bbbf41e4aa6eb4a5907c3bd4
Autor:
Yonghan He, Raphael Koch, Vivekananda Budamagunta, Peiyi Zhang, Xuan Zhang, Sajid Khan, Dinesh Thummuri, Yuma T. Ortiz, Xin Zhang, Dongwen Lv, Janet S. Wiegand, Wen Li, Adam C. Palmer, Guangrong Zheng, David M. Weinstock, Daohong Zhou
Publikováno v:
Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-13 (2020)
Abstract Background Patients with advanced T cell lymphomas (TCLs) have limited therapeutic options and poor outcomes in part because their TCLs evade apoptosis through upregulation of anti-apoptotic Bcl-2 proteins. Subsets of TCL cell lines, patient
Externí odkaz:
https://doaj.org/article/5465bbd0654b43a790ad6905bd6e9a47
Autor:
Yonghan He, Sajid Khan, Zhiguang Huo, Dongwen Lv, Xuan Zhang, Xingui Liu, Yaxia Yuan, Robert Hromas, Mingjiang Xu, Guangrong Zheng, Daohong Zhou
Publikováno v:
Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-24 (2020)
Abstract Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that utilize the ubiquitin proteasome system (UPS) to degrade proteins of interest (POI). PROTACs are potentially superior to conventional small molecule inhibit
Externí odkaz:
https://doaj.org/article/d50c64223d3741a28884e3b3aee78b69
Autor:
Yonghan He, Xuan Zhang, Jianhui Chang, Ha-Neui Kim, Peiyi Zhang, Yingying Wang, Sajid Khan, Xingui Liu, Xin Zhang, Dongwen Lv, Lin Song, Wen Li, Dinesh Thummuri, Yaxia Yuan, Janet S. Wiegand, Yuma T. Ortiz, Vivekananda Budamagunta, Jennifer H. Elisseeff, Judith Campisi, Maria Almeida, Guangrong Zheng, Daohong Zhou
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Senolytics have the potential to extend healthspan by selectively killing senescent cells (SCs), but senolytics that target Bcl-xl may cause platelet toxicity. Here, the authors generated a Bcl-xl proteolysis-targeting chimera (PROTAC) senolytic, whi
Externí odkaz:
https://doaj.org/article/dc8e747a1c2b46fbb1cf6eb91566a85f
Autor:
Jonathan J. Cho, Zhiwei Xu, Upasana Parthasarathy, Theodore T. Drashansky, Eric Y. Helm, Ashley N. Zuniga, Kyle J. Lorentsen, Samira Mansouri, Joshua Y. Cho, Mariola J. Edelmann, Duc M. Duong, Torben Gehring, Thomas Seeholzer, Daniel Krappmann, Mohammad N. Uddin, Danielle Califano, Rejean L. Wang, Lei Jin, Hongmin Li, Dongwen Lv, Daohong Zhou, Liang Zhou, Dorina Avram
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Ubiquitination may control protein stability or function. Here the authors show that an ubiquitination enzyme, Hectd3, ubiquitinates Stat3 and Malt1 to modulate their function but not degradation in T cells, and thereby promoting the differentiation
Externí odkaz:
https://doaj.org/article/1894c8d823ab4177ab03857c322a339c
Autor:
Xiaohong Zhou, Ke Wang, Dongwen Lv, Chengjun Wu, Jiarui Li, Pei Zhao, Zhishan Lin, Lipu Du, Yueming Yan, Xingguo Ye
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79390 (2013)
Agrobacterium-mediated plant transformation is an extremely complex and evolved process involving genetic determinants of both the bacteria and the host plant cells. However, the mechanism of the determinants remains obscure, especially in some cerea
Externí odkaz:
https://doaj.org/article/34fd758c42af4272be75412e2800305c
Publikováno v:
Cancer Research. 83:4792-4792
Cellular senescence is an emerging hallmark of cancer. Senescent cells can lead to tumor development and chronic inflammation that stimulate age-related diseases. The secretion of senescent cells also generates an inflammatory environment that promot
Autor:
Jing Pei, Yufeng Xiao, Xingui Liu, Wanyi Hu, Amin Sobh, Yaxia Yuan, Shuo Zhou, Nan Hua, Samuel G. Mackintosh, Xuan Zhang, Kari B. Basso, Manasi Kamat, Qingping Yang, Jonathan D. Licht, Guangrong Zheng, Daohong Zhou, Dongwen Lv
Publikováno v:
Cell Chemical Biology. 30:203-213.e17
Autor:
Dinesh Thummuri, Sajid Khan, David M. Weinstock, Dongwen Lv, Yuma T. Ortiz, Xuan Zhang, Guangrong Zheng, Janet S. Wiegand, Vivekananda Budamagunta, Daohong Zhou, Adam C. Palmer, Peiyi Zhang, Wen Li, Raphael Koch, Yonghan He, Xin Zhang
Publikováno v:
Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-13 (2020)
Journal of Hematology & Oncology
Journal of Hematology & Oncology
Background Patients with advanced T cell lymphomas (TCLs) have limited therapeutic options and poor outcomes in part because their TCLs evade apoptosis through upregulation of anti-apoptotic Bcl-2 proteins. Subsets of TCL cell lines, patient-derived