Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Dongshi Chen"'
Autor:
Lei Sun, Arabella H. Wan, Shijia Yan, Ruonian Liu, Jiarui Li, Zhuolong Zhou, Ruirui Wu, Dongshi Chen, Xianzhang Bu, Jingxing Ou, Kai Li, Xiongbin Lu, Guohui Wan, Zunfu Ke
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 1, Pp 223-240 (2024)
Lenvatinib, a second-generation multi-receptor tyrosine kinase inhibitor approved by the FDA for first-line treatment of advanced liver cancer, facing limitations due to drug resistance. Here, we applied a multidimensional, high-throughput screening
Externí odkaz:
https://doaj.org/article/6fd491e1a58a4961a1629f26aa3391ae
Editorial: Biomarkers, functional mechanisms, and therapeutic potentials in gastrointestinal cancers
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/9b3749a52d48447a93b1d4749ff81054
Autor:
Dongshi Chen, Alyssa D. Gregory, Xiaoyun Li, Jianxin Wei, Christine L. Burton, Gregory Gibson, Stephen J. Scott, Claudette M. St. Croix, Yingze Zhang, Steven D. Shapiro
Publikováno v:
JCI Insight, Vol 6, Iss 12 (2021)
Necroptosis has emerged as a potential mechanism in the pathogenesis of chronic obstructive pulmonary disease (COPD). Here, we found that markers of necroptosis, including high mobility group box 1 release and phosphorylation of mixed lineage kinase
Externí odkaz:
https://doaj.org/article/67eaec95a72b40a8947c6cb80f5b5ccb
Autor:
Kyle Knickelbein, Jingshan Tong, Dongshi Chen, Yi-Jun Wang, Sandra Misale, Alberto Bardelli, Jian Yu, Lin Zhang
Publikováno v:
Oncogene.
Autor:
Lin Zhang, Jian Yu, Yongqian Shu, Crissy Dudgeon, Dongshi Chen, Kan He, Kyle Knickelbein, Jing Sun
Aurora kinases play a key role in mitosis and are frequently overexpressed in a variety of tumor cells. Inhibition of aurora kinases results in mitotic arrest and death of cancer cells, and has been explored as an anticancer strategy. However, how au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27563d55674e21daefb50885dd01b2e5
https://doi.org/10.1158/1535-7163.c.6536268
https://doi.org/10.1158/1535-7163.c.6536268
Autor:
Lin Zhang, Jian Yu, Yongqian Shu, Crissy Dudgeon, Dongshi Chen, Kan He, Kyle Knickelbein, Jing Sun
PDF file - 364KB, Figure S1: p53-independent PUMA induction by the aurora kinase inhibitor VX-680 in colon cancer cells; Figure S2: PUMA mediates the apoptotic and anticancer activities of ZM-447439 and VX-680; Figure S3: Analysis of transcription fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6696542ea95b73a536d9428d5666e584
https://doi.org/10.1158/1535-7163.22499811
https://doi.org/10.1158/1535-7163.22499811
Autor:
Lin Zhang, Jian Yu, Fangdong Zou, Zaneta Nikolovska-Coleska, Dongshi Chen, Shuai Tan, Peng Wang, Jingshan Tong
Table S1. Sequences of PCR primers used for vector construction and PCR screening of Mcl-1-KI cell lines, and for analysis of Mcl-1 mRNA expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d316ff3192460647ff253cdafb7e2af
https://doi.org/10.1158/0008-5472.22416713.v1
https://doi.org/10.1158/0008-5472.22416713.v1
Autor:
Lin Zhang, Jian Yu, Fangdong Zou, Zaneta Nikolovska-Coleska, Dongshi Chen, Shuai Tan, Peng Wang, Jingshan Tong
Figure S1. Regorafenib and sorafenib did not affect Mcl-1 mRNA expression but induced GSK3β-dependent Mcl-1 degradation. A transfected quadruple mutant in 4 putative phosphorylation sites (S121A/E125A/S159A/T163A) of Mcl-1 was resistant to regorafen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f84a670cf35a632c736cd4ed52f5ae8
https://doi.org/10.1158/0008-5472.22416716.v1
https://doi.org/10.1158/0008-5472.22416716.v1
Autor:
Lin Zhang, Jian Yu, Fangdong Zou, Zaneta Nikolovska-Coleska, Dongshi Chen, Shuai Tan, Peng Wang, Jingshan Tong
The Bcl-2 family protein Mcl-1 is often degraded in cancer cells subjected to effective therapeutic treatment, and defective Mcl-1 degradation has been associated with intrinsic and acquired drug resistance. However, a causal relationship between Mcl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14a0650b6dd1528ae2d2a5f95a71b49d
https://doi.org/10.1158/0008-5472.c.6509627.v1
https://doi.org/10.1158/0008-5472.c.6509627.v1
PDF file - 301KB, Figure S1. Potential roles of transcription factors in PUMA induction by regorafenib in CRC cells. Figure S2. p65 mediates PUMA induction by regorafenib in CRC cells. Figure S3. PUMA-dependent chemosensitization by regorafenib in CR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad531c35eab8ba081aa6cb2a21ede843
https://doi.org/10.1158/1078-0432.22449252
https://doi.org/10.1158/1078-0432.22449252