Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Dongshan YANG"'
Autor:
Van Phuc Nguyen, Athanasios J. Karoukis, Justin Hu, Zhuying Wei, Dongshan Yang, Abigail T. Fahim, Xueding Wang, Yannis M. Paulus
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Retinal pigment epithelial (RPE) cells play a crucial role in the health of the retina, and their dysfunction is associated with various ocular diseases. The transplantation of RPE cells has been proposed as a potential treatment for numerou
Externí odkaz:
https://doaj.org/article/47176f8b6dbb4c4fbd58462d54da1ae8
Publikováno v:
Meitan kexue jishu, Vol 52, Iss 6, Pp 14-28 (2024)
Aiming at the problem that roof deformation of cross fault roof cutting and pressure relief self-formed roadway is large and difficult to support, the mechanism of roof deformation of self-formed roadway in cross fault roof cutting and pressure-relie
Externí odkaz:
https://doaj.org/article/f1060919fcf74942bcddd5db911b28a0
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Usher syndrome type 2A (USH2A) is a genetic disorder characterized by retinal degeneration and hearing loss. To better understand the pathogenesis and progression of this syndrome, animal models such as USH2A knockout (USH2AKO) rabbits have
Externí odkaz:
https://doaj.org/article/491b7c1dc0ff4eeb8dcb139c5d403a1c
Autor:
Heng Zhang, Jiaxuan Feng, Hongqiao Zhu, Shun Xiao, Mingyuan Liu, Yili Xu, Dongshan Yang, Junjun Liu, Mingjin Guo
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
ObjectiveThis study aims to evaluate the feasibility, efficacy, and safety of a single-branched stent-graft with on-table fenestration for primary retrograde type A aortic dissection (RTAD) during thoracic endovascular aortic repair (TEVAR).Materials
Externí odkaz:
https://doaj.org/article/a1768955f3b04bf6b837c5e8a01e158a
Autor:
Linyuan Ma, Jinxue Ruan, Jun Song, Luan Wen, Dongshan Yang, Jiangyang Zhao, Xiaofeng Xia, Y. Eugene Chen, Jifeng Zhang, Jie Xu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Cas9 fused to DNA damage repair proteins can improve rates of gene knock-in but the chimeric protein is often large. Here the authors fuse Cas9 to a minimal Brex27 motif from BRCA2 consisting of thirty-six amino acids to enhance the efficacy and safe
Externí odkaz:
https://doaj.org/article/58d62b4781c84e8aa9e7b4d0d8b4512d
Design and Optimization of Trapezoidal Steering Mechanism based on Improved Particle Swarm Algorithm
Publikováno v:
Jixie chuandong, Vol 44, Pp 86-95 (2020)
In order to make the steering mechanism characteristic curve of the wheeled mobile robot closer to the ideal Ackerman steering characteristic curve and achieve precise steering purpose， the design and parameter optimization of its steering mechanis
Externí odkaz:
https://doaj.org/article/fe574002d62d4a65b78a76ab86d26734
Autor:
Yanbo Fan, Brooke N. Wolford, Haocheng Lu, Wenying Liang, Jinjian Sun, Wei Zhou, Oren Rom, Anubha Mahajan, Ida Surakka, Sarah E. Graham, Zhipeng Liu, Hyunbae Kim, Shweta Ramdas, Lars G. Fritsche, Jonas B. Nielsen, Maiken Elvestad Gabrielsen, Kristian Hveem, Dongshan Yang, Jun Song, Minerva T. Garcia-Barrio, Jifeng Zhang, Wanqing Liu, Kezhong Zhang, Cristen J. Willer, Y. Eugene Chen
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103196- (2021)
Summary: The rs58542926C >T (E167K) variant of the transmembrane 6 superfamily member 2 gene (TM6SF2) is associated with increased risks for nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D). Nevertheless, the role of the TM6SF2 rs58
Externí odkaz:
https://doaj.org/article/123d0eb5291545f598be4e64a51063ec
Autor:
Kemao Xiu, Laura Saunders, Luan Wen, Jinxue Ruan, Ruonan Dong, Jun Song, Dongshan Yang, Jifeng Zhang, Jie Xu, Y. Eugene Chen, Peter X. Ma
Publikováno v:
Cells, Vol 12, Iss 1, p 156 (2022)
Gene editing nucleases such as CRISPR/Cas9 have enabled efficient and precise gene editing in vitro and hold promise of eventually achieving in vivo gene editing based therapy. However, a major challenge for their use is the lack of a safe and effect
Externí odkaz:
https://doaj.org/article/93602edda32c46029d7ed99e5661f88a
Autor:
Jinxue Ruan, Hiroyuki Hirai, Dongshan Yang, Linyuan Ma, Xia Hou, Hong Jiang, Hongguang Wei, Carthic Rajagopalan, Hongmei Mou, Guoshun Wang, Jifeng Zhang, Kui Li, Yuqing E. Chen, Fei Sun, Jie Xu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 16, Iss , Pp 73-81 (2019)
Cystic fibrosis (CF) is a lethal autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Nuclease-mediated precise gene editing (PGE) represents a promising therapy for CF, for which an
Externí odkaz:
https://doaj.org/article/a456badb163c4c67808cc465e0c667bc
Publikováno v:
Cells, Vol 11, Iss 14, p 2186 (2022)
CRISPR–Cas9 is the state-of-the-art programmable genome-editing tool widely used in many areas. For safe therapeutic applications in clinical medicine, its off-target effect must be dramatically minimized. In recent years, extensive studies have be
Externí odkaz:
https://doaj.org/article/a5fa59a033e84b75a1502248665c71f7