Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Dongmyung Oh"'
Publikováno v:
eLife, Vol 10 (2021)
Clustering of ligand:receptor complexes on the cell membrane is widely presumed to have functional consequences for subsequent signal transduction. However, it is experimentally challenging to selectively manipulate receptor clustering without alteri
Externí odkaz:
https://doaj.org/article/6031d0ba643944d9a1e991839d41e8e6
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0195887 (2018)
The spatial location of proteins in living cells can be critical for their function. For example, the E. coli chemotaxis machinery is localized to the cell poles. Here we describe the polar localization of the serine chemoreceptor Tsr using a strain
Externí odkaz:
https://doaj.org/article/818a36f891f547bdb3480c36fda0b66c
Autor:
Joshua A Jadwin, Dongmyung Oh, Timothy G Curran, Mari Ogiue-Ikeda, Lin Jia, Forest M White, Kazuya Machida, Ji Yu, Bruce J Mayer
Publikováno v:
eLife, Vol 5 (2016)
While the affinities and specificities of SH2 domain-phosphotyrosine interactions have been well characterized, spatio-temporal changes in phosphosite availability in response to signals, and their impact on recruitment of SH2-containing proteins in
Externí odkaz:
https://doaj.org/article/1fdecacfc0a547c680275964c20c628e
Autor:
Dongmyung Oh, Zhongwen Chen, Kabir H. Biswas, Funing Bai, Hui Ting Ong, Michael P. Sheetz, Jay T. Groves
Publikováno v:
Biophys J
Cells sense a variety of extracellular growth factors and signaling molecules through numerous distinct receptor tyrosine kinases (RTKs) on the cell surface. In many cases, the same intracellular signaling molecules interact with more than one type o
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Clustering of ligand:receptor complexes on the cell membrane is widely presumed to have functional consequences for subsequent signal transduction. However, it is experimentally challenging to selectively manipulate receptor clustering without alteri
Autor:
Yuhong Cao, Dongmyung Oh, Chun-Wei Lin, Peidong Yang, Steven Alvarez, Jay T. Groves, Zhongwen Chen
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 5
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 5
Multicolor single-molecule tracking (SMT) provides a powerful tool to mechanistically probe molecular interactions in living cells. However, because of the limitations in the optical and chemical properties of currently available fluorophores and the
Publikováno v:
Insights of Biomedical Research. 4
We report the case of a young patient with left breast cancer with stage IIB (T2N1M0), negative hormone receptors, HER2-positive and no particular medical history. The patient was particularly sensitive to the neurological and allergic-type toxicity
Autor:
Mingxi Yao, Zhongwen Chen, Beverly Yang, Jay T. Groves, Alok Kumar Dubey, Michael P. Sheetz, Dongmyung Oh
Publikováno v:
Current Opinion in Cell Biology. 51:97-102
Receptor tyrosine kinases (RTKs), such as the EGF receptor family, and adhesion molecules, such as integrins, have historically been viewed to have distinctly separable roles in the cell. In this classical view, integrins mediate mechanical interacti
Publikováno v:
Proceedings of the National Academy of Sciences. 115
Recent studies have revealed pronounced effects of the spatial distribution of EphA2 receptors on cellular response to receptor activation. However, little is known about molecular mechanisms underlying this spatial sensitivity, in part due to lack o