Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Dongling Hao"'
Autor:
Chengde Wu, Gong Zhen, Xijun Sheng, Chen Shuhui, Shoubo Zhang, Jie Shen, Huqiang Lv, Wang Xuehai, Jun Wang, Zhibo Qi, Hu Guoping, Sun Wenjie, Sun Guanglong, Yuchuan Zhu, Weifeng Mao, Liang Shen, Xuejun Zhang, Yan Pan, Minghui Cui, Ronghua Tu, Dongling Hao, Shuhua Han, Shen Chunli, Xin Li, Li Yi, Lei Huang, Jian Li
Publikováno v:
ACS Medicinal Chemistry Letters. 11:1863-1868
The identification and lead optimization of a series of pyrazolo[3,4-d]pyridazinone derivatives are described as a novel class of potent irreversible BTK inhibitors, resulting in the discovery of compound 8. Compound 8 exhibited high potency against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3f1f21257cb83e14e533ceaa55167e4
https://doi.org/10.1021/acsmedchemlett.9b00395
https://doi.org/10.1021/acsmedchemlett.9b00395
Autor:
Amy Guan, Bo Gao, Ning Li, Chengde Wu, Jian Li, Yongguo Li, Yan Pan, Liang Shen, Miao He, Lei Huang, Jikui Sun, Yu Tao, Chichung Chan, Gong Zhen, Hongyu Yuan, Li Yi, Zhengang Peng, Li Jie, Xiulian Lu, Chen Shuhui, Dongling Hao
Publikováno v:
ACS Medicinal Chemistry Letters. 9:256-261
[Image: see text] The identification and lead optimization of a series of pyridopyrimidinone derivatives are described as a novel class of efficacious dual PI3K/mTOR inhibitors, resulting in the discovery of 31. Compound 31 exhibited high enzyme acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b3dbc008661a0a0c9ac0473178d68b
https://doi.org/10.1021/acsmedchemlett.8b00002
https://doi.org/10.1021/acsmedchemlett.8b00002
Autor:
Xuejun, Zhang, Xijun, Sheng, Jie, Shen, Shoubo, Zhang, Wenjie, Sun, Chunli, Shen, Yi, Li, Jun, Wang, Huqiang, Lv, Minghui, Cui, Yuchuan, Zhu, Lei, Huang, Dongling, Hao, Zhibo, Qi, Guanglong, Sun, Weifeng, Mao, Yan, Pan, Liang, Shen, Xin, Li, Guoping, Hu, Zhen, Gong, Shuhua, Han, Jian, Li, Shuhui, Chen, Ronghua, Tu, Xuehai, Wang, Chengde, Wu
Publikováno v:
ACS Med Chem Lett
[Image: see text] The identification and lead optimization of a series of pyrazolo[3,4-d]pyridazinone derivatives are described as a novel class of potent irreversible BTK inhibitors, resulting in the discovery of compound 8. Compound 8 exhibited hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::09e6ebe288047e74c531f0c5efed0826
https://pubmed.ncbi.nlm.nih.gov/33062165
https://pubmed.ncbi.nlm.nih.gov/33062165
Autor:
Lei Huang, Peipei Jiang, Jikui Sun, Ning Li, Chengde Wu, Dongling Hao, Li Yi, Dan Yao, Nengyang Shih, Chen Shuhui, Xiulian Lu, Yu Tao, Lingwei Kong, Amy Guan, Bo Gao, Hongyu Yuan, Yuxin Qin
Publikováno v:
Cancer Research. 78:5460-5460
Background: The PI3K/AKT/mTOR signaling pathway is important in regulating cell cycle, which is directly related to cellular quiescence, proliferation and longevity. Dysfunctional signaling of the PI3K/AKT/mTOR pathway in cancer, and its crucial role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb8e2dac833fa1903afffbcfed2fd59d
https://doi.org/10.1158/1538-7445.am2018-5460
https://doi.org/10.1158/1538-7445.am2018-5460
Publikováno v:
ChemInform. 44
An efficient method for triarylmethanimine synthesis promoted by a Lewis acid–base pair (AlCl3–Et3N) was designed using mechanistic analysis with the aid of density functional theory. A series of triarylmethanimines were successfully prepared und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::305d578e6d068ac3fd5fbaffb11cb430
https://doi.org/10.1002/chin.201316063
https://doi.org/10.1002/chin.201316063
Publikováno v:
Australian Journal of Chemistry. 65:1390
An efficient method for triarylmethanimine synthesis promoted by a Lewis acid–base pair (AlCl3–Et3N) was designed using mechanistic analysis with the aid of density functional theory. A series of triarylmethanimines were successfully prepared und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62c0f4952381c54255d5231061287cd2
https://doi.org/10.1071/ch12090
https://doi.org/10.1071/ch12090