A Comparative Study between A Protein Based Amorphous Formulation and Other Dissolution Rate Enhancing Approaches: A Case Study with Rifaximin

Autor: Xuezhi Zhuo, Maud Margrethe Brekstad Kjellin, Zarah Schaal, Tengyu Zhang, Korbinian Löbmann, Donglei Leng

Publikováno v: Pharmaceutics, Vol 15, Iss 1, p 126 (2022)

Amorphous solid dispersions (ASDs) based on proteins as co-formers have previously shown promising potential to improve the solubility and bioavailability of poorly water-soluble drugs. In particular, whey proteins have shown to be promising co-forme

Externí odkaz: https://doaj.org/article/468e59b7884941d0b6e951dacb38b72d

Development and validation of a rapid and sensitive UHPLC–MS/MS method for the determination of paliperidone in beagle dog plasma

Autor: Hongming Chen, Longshan Zhao, Guangjing Li, Donglei Leng, Panqin Ma, Lijin Tong, Tianhong Zhang

Publikováno v: Asian Journal of Pharmaceutical Sciences, Vol 9, Iss 5, Pp 286-292 (2014)

In order to evaluate the pharmacokinetic profile of paliperidone extended-release tablets in vivo, a simple and rapid ultra-high performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) method was developed and validated for the d

Externí odkaz: https://doaj.org/article/b34b48d5ad174f21b9ceb837370e1080

Stabilizing Mechanisms of β-Lactoglobulin in Amorphous Solid Dispersions of Indomethacin

Autor: Aleksei Kabedev, Xuezhi Zhuo, Donglei Leng, Vito Foderà, Min Zhao, Per Larsson, Christel A. S. Bergström, Korbinian Löbmann

Publikováno v: Kabedev, A, Zhuo, X, Leng, D, Foderà, V, Zhao, M, Larsson, P, Bergström, C A S & Löbmann, K 2022, ' Stabilizing mechanisms of β-lactoglobulin in amorphous solid dispersions of indomethacin ', Molecular Pharmaceutics, vol. 19, no. 11, pp. 3922-3933 . https://doi.org/10.1021/acs.molpharmaceut.2c00397
Kabedev, A, Zhuo, X, Leng, D, Foderà, V, Zhao, M, Larsson, P, Bergström, C A S & Löbmann, K 2022, ' Stabilizing Mechanisms of β-Lactoglobulin in Amorphous Solid Dispersions of Indomethacin ', Molecular Pharmaceutics, vol. 19, no. 11, pp. 3922–3933 . https://doi.org/10.1021/acs.molpharmaceut.2c00397

Proteins, and in particular whey proteins, have recently been introduced as a promising excipient class for stabilizing amorphous solid dispersions. However, despite the efficacy of the approach, the molecular mechanisms behind the stabilization of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde64920fa1849af9775aa78cee253cc
https://doi.org/10.1021/acs.molpharmaceut.2c00397

Enhanced dissolution rate of nimodipine through β-lactoglobulin based formulation

Autor: Donglei Leng, Bulut Bulduk, Johanna Anlahr, Wouter Müllers, Korbinian Löbmann

Publikováno v: International Journal of Pharmaceutics. 635:122693

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c32ffda9695169f6463041e0839a42d7
https://doi.org/10.1016/j.ijpharm.2023.122693

Design of Inhalable Solid Dosage Forms of Budesonide and Theophylline for Pulmonary Combination Therapy

Autor: Korbinian Löbmann, Eric Ofosu Kissi, Donglei Leng, Kaushik Thanki, Camilla Foged, Thomas Rades, Mingshi Yang, Elias Fattal

Publikováno v: AAPS PharmSciTech. 20(3)

Corticosteroid resistance poses a major challenge to effective treatment of chronic obstructive pulmonary diseases. However, corticosteroid resistance can be overcome by co-administration of theophylline. The aim of this study was to formulate the co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7be1447d7d2ad40dd2db487fdb6d30b
https://pubmed.ncbi.nlm.nih.gov/30847607