Phase 1 study of oral TAS-102 in patients with refractory metastatic colorectal cancer

Autor: Hirokazu Mizuguchi, Manish R. Patel, Johanna C. Bendell, Fabio Benedetti, C. Zergebel, Robert J. Mayer, Donghu Lin, Lee S. Rosen, Jonathan W. Goldman, Jeffrey R. Infante

Publikováno v: Cancer Chemotherapy and Pharmacology

Purpose To evaluate safety of TAS-102 administered twice daily (bid) on days 1–5 and 8–12 of a 4-week cycle, confirm feasibility of the Japanese recommended dose (RD), 35 mg/m2, in Western patients with metastatic colorectal cancer (mCRC) refract

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b50744f48d8a6bb749d99c3d72bf8ee7
https://doi.org/10.1007/s00280-015-2850-4

Results of a Randomized, Double-Blind, Placebo-Controlled, Phase III Trial of Trifluridine/Tipiracil (TAS-102) Monotherapy in Asian Patients With Previously Treated Metastatic Colorectal Cancer: The TERRA Study.

Autor: Xu J; Jianming Xu, Affiliated Hospital Cancer Centre, Academy of Military Medical Sciences (The 307 Hospital Cancer Centre of People's Liberation Army); Lin Shen, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing; Hongming Pan, Sir Run Run Shaw Hospital Medical School, Zhejiang University, Hangzhou; Ruihua Xu, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou; Weijian Guo and Jin Li, Fudan University Shanghai Cancer Center; Tianshu Liu, Zhong Shan Hospital, Fudan University; Qi Li, Shanghai Jiaotong University affiliated First People's Hospital; Jin Li, Tongji University Affiliate Shanghai East Hospital, Shanghai; Chunmei Shi, Fujian Medical University Union Hospital, Fuzhou; Yuxian Bai, Third Affiliated Hospital of Harbin Medical University, Harbin; Feng Bi, West China Hospital, Sichuan University, Chengdu; Shukui Qin, Chinese People's Liberation Army Cancer Center of Nanjing Bayi Hospital, Nanjing; Changping Wu, The First People's Hospital of Changzhou, Changzhou; Dong Ma, Guangdong General Hospital, Guangzhou, Guangdong, China; Tae Won Kim, Asan Medical Center, University of Ulsan College of Medicine; Sae-Won Han, Seoul National University Hospital; Young Suk Park, Samsung Medical Center, Sungkyunkwan University School of Medicine; Joong Bae Ahn, Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University, College of Medicine, Seoul, Republic of Korea; Virote Sriuranpong, Chulalongkorn Hospital, Bangkok, Thailand; and Donghu Lin, Taiho Pharmaceutical, Tokyo, Japan., Kim TW; Jianming Xu, Affiliated Hospital Cancer Centre, Academy of Military Medical Sciences (The 307 Hospital Cancer Centre of People's Liberation Army); Lin Shen, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing; Hongming Pan, Sir Run Run Shaw Hospital Medical School, Zhejiang University, Hangzhou; Ruihua Xu, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou; Weijian Guo and Jin Li, Fudan University Shanghai Cancer Center; Tianshu Liu, Zhong Shan Hospital, Fudan University; Qi Li, Shanghai Jiaotong University affiliated First People's Hospital; Jin Li, Tongji University Affiliate Shanghai East Hospital, Shanghai; Chunmei Shi, Fujian Medical University Union Hospital, Fuzhou; Yuxian Bai, Third Affiliated Hospital of Harbin Medical University, Harbin; Feng Bi, West China Hospital, Sichuan University, Chengdu; Shukui Qin, Chinese People's Liberation Army Cancer Center of Nanjing Bayi Hospital, Nanjing; Changping Wu, The First People's Hospital of Changzhou, Changzhou; Dong Ma, Guangdong General Hospital, Guangzhou, Guangdong, China; Tae Won Kim, Asan Medical Center, University of Ulsan College of Medicine; Sae-Won Han, Seoul National University Hospital; Young Suk Park, Samsung Medical Center, Sungkyunkwan University School of Medicine; Joong Bae Ahn, Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University, College of Medicine, Seoul, Republic of Korea; Virote Sriuranpong, Chulalongkorn Hospital, Bangkok, Thailand; and Donghu Lin, Taiho Pharmaceutical, Tokyo, Japan., Shen L; Jianming Xu, Affiliated Hospital Cancer Centre, Academy of Military Medical Sciences (The 307 Hospital Cancer Centre of People's Liberation Army); Lin Shen, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing; Hongming Pan, Sir Run Run Shaw Hospital Medical School, Zhejiang University, Hangzhou; Ruihua Xu, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou; Weijian Guo and Jin Li, Fudan University Shanghai Cancer Center; Tianshu Liu, Zhong Shan Hospital, Fudan University; Qi Li, Shanghai Jiaotong University affiliated First People's Hospital; Jin Li, Tongji University Affiliate Shanghai East Hospital, Shanghai; Chunmei Shi, Fujian Medical University Union Hospital, Fuzhou; Yuxian Bai, Third Affiliated Hospital of Harbin Medical University, Harbin; Feng Bi, West China Hospital, Sichuan University, Chengdu; Shukui Qin, Chinese People's Liberation Army Cancer Center of Nanjing Bayi Hospital, Nanjing; Changping Wu, The First People's Hospital of Changzhou, Changzhou; Dong Ma, Guangdong General Hospital, Guangzhou, Guangdong, China; Tae Won Kim, Asan Medical Center, University of Ulsan College of Medicine; Sae-Won Han, Seoul National University Hospital; Young Suk Park, Samsung Medical Center, Sungkyunkwan University School of Medicine; Joong Bae Ahn, Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University, College of Medicine, Seoul, Republic of Korea; Virote Sriuranpong, Chulalongkorn Hospital, Bangkok, Thailand; and Donghu Lin, Taiho Pharmaceutical, Tokyo, Japan., Sriuranpong V; Jianming Xu, Affiliated Hospital Cancer Centre, Academy of Military Medical Sciences (The 307 Hospital Cancer Centre of People's Liberation Army); Lin Shen, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing; Hongming Pan, Sir Run Run Shaw Hospital Medical School, Zhejiang University, Hangzhou; Ruihua Xu, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou; Weijian Guo and Jin Li, Fudan University Shanghai Cancer Center; Tianshu Liu, Zhong Shan Hospital, Fudan University; Qi Li, Shanghai Jiaotong University affiliated First People's Hospital; Jin Li, Tongji University Affiliate Shanghai East Hospital, Shanghai; Chunmei Shi, Fujian Medical University Union Hospital, Fuzhou; Yuxian Bai, Third Affiliated Hospital of Harbin Medical University, Harbin; Feng Bi, West China Hospital, Sichuan University, Chengdu; Shukui Qin, Chinese People's Liberation Army Cancer Center of Nanjing Bayi Hospital, Nanjing; Changping Wu, The First People's Hospital of Changzhou, Changzhou; Dong Ma, Guangdong General Hospital, Guangzhou, Guangdong, China; Tae Won Kim, Asan Medical Center, University of Ulsan College of Medicine; Sae-Won Han, Seoul National University Hospital; Young Suk Park, Samsung Medical Center, Sungkyunkwan University School of Medicine; Joong Bae Ahn, Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University, College of Medicine, Seoul, Republic of Korea; Virote Sriuranpong, Chulalongkorn Hospital, Bangkok, Thailand; and Donghu Lin, Taiho Pharmaceutical, Tokyo, Japan., Pan H; Jianming Xu, Affiliated Hospital Cancer Centre, Academy of Military Medical Sciences (The 307 Hospital Cancer Centre of People's Liberation Army); Lin Shen, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing; Hongming Pan, Sir Run Run Shaw Hospital Medical School, Zhejiang University, Hangzhou; Ruihua Xu, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou; Weijian Guo and Jin Li, Fudan University Shanghai Cancer Center; Tianshu Liu, Zhong Shan Hospital, Fudan University; Qi Li, Shanghai Jiaotong University affiliated First People's Hospital; Jin Li, Tongji University Affiliate Shanghai East Hospital, Shanghai; Chunmei Shi, Fujian Medical University Union Hospital, Fuzhou; Yuxian Bai, Third Affiliated Hospital of Harbin Medical University, Harbin; Feng Bi, West China Hospital, Sichuan University, Chengdu; Shukui Qin, Chinese People's Liberation Army Cancer Center of Nanjing Bayi Hospital, Nanjing; Changping Wu, The First People's Hospital of Changzhou, Changzhou; Dong Ma, Guangdong General Hospital, Guangzhou, Guangdong, China; Tae Won Kim, Asan Medical Center, University of Ulsan College of Medicine; Sae-Won Han, Seoul National University Hospital; Young Suk Park, Samsung Medical Center, Sungkyunkwan University School of Medicine; Joong Bae Ahn, Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University, College of Medicine, Seoul, Republic of Korea; Virote Sriuranpong, Chulalongkorn Hospital, Bangkok, Thailand; and Donghu Lin, Taiho Pharmaceutical, Tokyo, Japan., Xu R; Jianming Xu, Affiliated Hospital Cancer Centre, Academy of Military Medical Sciences (The 307 Hospital Cancer Centre of People's Liberation Army); Lin Shen, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing; Hongming Pan, Sir Run Run Shaw Hospital Medical School, Zhejiang University, Hangzhou; Ruihua Xu, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou; Weijian Guo and Jin Li, Fudan University Shanghai Cancer Center; Tianshu Liu, Zhong Shan Hospital, Fudan University; Qi Li, Shanghai Jiaotong University affiliated First People's Hospital; Jin Li, Tongji University Affiliate Shanghai East Hospital, Shanghai; Chunmei Shi, Fujian Medical University Union Hospital, Fuzhou; Yuxian Bai, Third Affiliated Hospital of Harbin Medical University, Harbin; Feng Bi, West China Hospital, Sichuan University, Chengdu; Shukui Qin, Chinese People's Liberation Army Cancer Center of Nanjing Bayi Hospital, Nanjing; Changping Wu, The First People's Hospital of Changzhou, Changzhou; Dong Ma, Guangdong General Hospital, Guangzhou, Guangdong, China; Tae Won Kim, Asan Medical Center, University of Ulsan College of Medicine; Sae-Won Han, Seoul National University Hospital; Young Suk Park, Samsung Medical Center, Sungkyunkwan University School of Medicine; Joong Bae Ahn, Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University, College of Medicine, Seoul, Republic of Korea; Virote Sriuranpong, Chulalongkorn Hospital, Bangkok, Thailand; and Donghu Lin, Taiho Pharmaceutical, Tokyo, Japan., Guo W; Jianming Xu, Affiliated Hospital Cancer Centre, Academy of Military Medical Sciences (The 307 Hospital Cancer Centre of People's Liberation Army); Lin Shen, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing; Hongming Pan, Sir Run Run Shaw Hospital Medical School, Zhejiang University, Hangzhou; Ruihua Xu, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou; Weijian Guo and Jin Li, Fudan University Shanghai Cancer Center; Tianshu Liu, Zhong Shan Hospital, Fudan University; Qi Li, Shanghai Jiaotong University affiliated First People's Hospital; Jin Li, Tongji University Affiliate Shanghai East Hospital, Shanghai; Chunmei Shi, Fujian Medical University Union Hospital, Fuzhou; Yuxian Bai, Third Affiliated Hospital of Harbin Medical University, Harbin; Feng Bi, West China Hospital, Sichuan University, Chengdu; Shukui Qin, Chinese People's Liberation Army Cancer Center of Nanjing Bayi Hospital, Nanjing; Changping Wu, The First People's Hospital of Changzhou, Changzhou; Dong Ma, Guangdong General Hospital, Guangzhou, Guangdong, China; Tae Won Kim, Asan Medical Center, University of Ulsan College of Medicine; Sae-Won Han, Seoul National University Hospital; Young Suk Park, Samsung Medical Center, Sungkyunkwan University School of Medicine; Joong Bae Ahn, Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University, College of Medicine, Seoul, Republic of Korea; Virote Sriuranpong, Chulalongkorn Hospital, Bangkok, Thailand; and Donghu Lin, Taiho Pharmaceutical, Tokyo, Japan., Han SW; Jianming Xu, Affiliated Hospital Cancer Centre, Academy of Military Medical Sciences (The 307 Hospital Cancer Centre of People's Liberation Army); Lin Shen, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing; Hongming Pan, Sir Run Run Shaw Hospital Medical School, Zhejiang University, Hangzhou; Ruihua Xu, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou; Weijian Guo and Jin Li, Fudan University Shanghai Cancer Center; Tianshu Liu, Zhong Shan Hospital, Fudan University; Qi Li, Shanghai Jiaotong University affiliated First People's Hospital; Jin Li, Tongji University Affiliate Shanghai East Hospital, Shanghai; Chunmei Shi, Fujian Medical University Union Hospital, Fuzhou; Yuxian Bai, Third Affiliated Hospital of Harbin Medical University, Harbin; Feng Bi, West China Hospital, Sichuan University, Chengdu; Shukui Qin, Chinese People's Liberation Army Cancer Center of Nanjing Bayi Hospital, Nanjing; Changping Wu, The First People's Hospital of Changzhou, Changzhou; Dong Ma, Guangdong General Hospital, Guangzhou, Guangdong, China; Tae Won Kim, Asan Medical Center, University of Ulsan College of Medicine; Sae-Won Han, Seoul National University Hospital; Young Suk Park, Samsung Medical Center, Sungkyunkwan University School of Medicine; Joong Bae Ahn, Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University, College of Medicine, Seoul, Republic of Korea; Virote Sriuranpong, Chulalongkorn Hospital, Bangkok, Thailand; and Donghu Lin, Taiho Pharmaceutical, Tokyo, Japan., Liu T; Jianming Xu, Affiliated Hospital Cancer Centre, Academy of Military Medical Sciences (The 307 Hospital Cancer Centre of People's Liberation Army); Lin Shen, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing; Hongming Pan, Sir Run Run Shaw Hospital Medical School, Zhejiang University, Hangzhou; Ruihua Xu, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou; Weijian Guo and Jin Li, Fudan University Shanghai Cancer Center; Tianshu Liu, Zhong Shan Hospital, Fudan University; Qi Li, Shanghai Jiaotong University affiliated First People's Hospital; Jin Li, Tongji University Affiliate Shanghai East Hospital, Shanghai; Chunmei Shi, Fujian Medical University Union Hospital, Fuzhou; Yuxian Bai, Third Affiliated Hospital of Harbin Medical University, Harbin; Feng Bi, West China Hospital, Sichuan University, Chengdu; Shukui Qin, Chinese People's Liberation Army Cancer Center of Nanjing Bayi Hospital, Nanjing; Changping Wu, The First People's Hospital of Changzhou, Changzhou; Dong Ma, Guangdong General Hospital, Guangzhou, Guangdong, China; Tae Won Kim, Asan Medical Center, University of Ulsan College of Medicine; Sae-Won Han, Seoul National University Hospital; Young Suk Park, Samsung Medical Center, Sungkyunkwan University School of Medicine; Joong Bae Ahn, Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University, College of Medicine, Seoul, Republic of Korea; Virote Sriuranpong, Chulalongkorn Hospital, Bangkok, Thailand; and Donghu Lin, Taiho Pharmaceutical, Tokyo, Japan., Park YS; Jianming Xu, Affiliated Hospital Cancer Centre, Academy of Military Medical Sciences (The 307 Hospital Cancer Centre of People's Liberation Army); Lin Shen, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing; Hongming Pan, Sir Run Run Shaw Hospital Medical School, Zhejiang University, Hangzhou; Ruihua Xu, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou; Weijian Guo and Jin Li, Fudan University Shanghai Cancer Center; Tianshu Liu, Zhong Shan Hospital, Fudan University; Qi Li, Shanghai Jiaotong University affiliated First People's Hospital; Jin Li, Tongji University Affiliate Shanghai East Hospital, Shanghai; Chunmei Shi, Fujian Medical University Union Hospital, Fuzhou; Yuxian Bai, Third Affiliated Hospital of Harbin Medical University, Harbin; Feng Bi, West China Hospital, Sichuan University, Chengdu; Shukui Qin, Chinese People's Liberation Army Cancer Center of Nanjing Bayi Hospital, Nanjing; Changping Wu, The First People's Hospital of Changzhou, Changzhou; Dong Ma, Guangdong General Hospital, Guangzhou, Guangdong, China; Tae Won Kim, Asan Medical Center, University of Ulsan College of Medicine; Sae-Won Han, Seoul National University Hospital; Young Suk Park, Samsung Medical Center, Sungkyunkwan University School of Medicine; Joong Bae Ahn, Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University, College of Medicine, Seoul, Republic of Korea; Virote Sriuranpong, Chulalongkorn Hospital, Bangkok, Thailand; and Donghu Lin, Taiho Pharmaceutical, Tokyo, Japan., Shi C; Jianming Xu, Affiliated Hospital Cancer Centre, Academy of Military Medical Sciences (The 307 Hospital Cancer Centre of People's Liberation Army); Lin Shen, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing; Hongming Pan, Sir Run Run Shaw Hospital Medical School, Zhejiang University, Hangzhou; Ruihua Xu, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou; Weijian Guo and Jin Li, Fudan University Shanghai Cancer Center; Tianshu Liu, Zhong Shan Hospital, Fudan University; Qi Li, Shanghai Jiaotong University affiliated First People's Hospital; Jin Li, Tongji University Affiliate Shanghai East Hospital, Shanghai; Chunmei Shi, Fujian Medical University Union Hospital, Fuzhou; Yuxian Bai, Third Affiliated Hospital of Harbin Medical University, Harbin; Feng Bi, West China Hospital, Sichuan University, Chengdu; Shukui Qin, Chinese People's Liberation Army Cancer Center of Nanjing Bayi Hospital, Nanjing; Changping Wu, The First People's Hospital of Changzhou, Changzhou; Dong Ma, Guangdong General Hospital, Guangzhou, Guangdong, China; Tae Won Kim, Asan Medical Center, University of Ulsan College of Medicine; Sae-Won Han, Seoul National University Hospital; Young Suk Park, Samsung Medical Center, Sungkyunkwan University School of Medicine; Joong Bae Ahn, Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University, College of Medicine, Seoul, Republic of Korea; Virote Sriuranpong, Chulalongkorn Hospital, Bangkok, Thailand; and Donghu Lin, Taiho Pharmaceutical, Tokyo, Japan., Bai Y; Jianming Xu, Affiliated Hospital Cancer Centre, Academy of Military Medical Sciences (The 307 Hospital Cancer Centre of People's Liberation Army); Lin Shen, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing; Hongming Pan, Sir Run Run Shaw Hospital Medical School, Zhejiang University, Hangzhou; Ruihua Xu, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou; Weijian Guo and Jin Li, Fudan University Shanghai Cancer Center; Tianshu Liu, Zhong Shan Hospital, Fudan University; Qi Li, Shanghai Jiaotong University affiliated First People's Hospital; Jin Li, Tongji University Affiliate Shanghai East Hospital, Shanghai; Chunmei Shi, Fujian Medical University Union Hospital, Fuzhou; Yuxian Bai, Third Affiliated Hospital of Harbin Medical University, Harbin; Feng Bi, West China Hospital, Sichuan University, Chengdu; Shukui Qin, Chinese People's Liberation Army Cancer Center of Nanjing Bayi Hospital, Nanjing; Changping Wu, The First People's Hospital of Changzhou, Changzhou; Dong Ma, Guangdong General Hospital, Guangzhou, Guangdong, China; Tae Won Kim, Asan Medical Center, University of Ulsan College of Medicine; Sae-Won Han, Seoul National University Hospital; Young Suk Park, Samsung Medical Center, Sungkyunkwan University School of Medicine; Joong Bae Ahn, Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University, College of Medicine, Seoul, Republic of Korea; Virote Sriuranpong, Chulalongkorn Hospital, Bangkok, Thailand; and Donghu Lin, Taiho Pharmaceutical, Tokyo, Japan., Bi F; Jianming Xu, Affiliated Hospital Cancer Centre, Academy of Military Medical Sciences (The 307 Hospital Cancer Centre of People's Liberation Army); Lin Shen, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing; Hongming Pan, Sir Run Run Shaw Hospital Medical School, Zhejiang University, Hangzhou; Ruihua Xu, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou; Weijian Guo and Jin Li, Fudan University Shanghai Cancer Center; Tianshu Liu, Zhong Shan Hospital, Fudan University; Qi Li, Shanghai Jiaotong University affiliated First People's Hospital; Jin Li, Tongji University Affiliate Shanghai East Hospital, Shanghai; Chunmei Shi, Fujian Medical University Union Hospital, Fuzhou; Yuxian Bai, Third Affiliated Hospital of Harbin Medical University, Harbin; Feng Bi, West China Hospital, Sichuan University, Chengdu; Shukui Qin, Chinese People's Liberation Army Cancer Center of Nanjing Bayi Hospital, Nanjing; Changping Wu, The First People's Hospital of Changzhou, Changzhou; Dong Ma, Guangdong General Hospital, Guangzhou, Guangdong, China; Tae Won Kim, Asan Medical Center, University of Ulsan College of Medicine; Sae-Won Han, Seoul National University Hospital; Young Suk Park, Samsung Medical Center, Sungkyunkwan University School of Medicine; Joong Bae Ahn, Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University, College of Medicine, Seoul, Republic of Korea; Virote Sriuranpong, Chulalongkorn Hospital, Bangkok, Thailand; and Donghu Lin, Taiho Pharmaceutical, Tokyo, Japan., Ahn JB; Jianming Xu, Affiliated Hospital Cancer Centre, Academy of Military Medical Sciences (The 307 Hospital Cancer Centre of People's Liberation Army); Lin Shen, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing; Hongming Pan, Sir Run Run Shaw Hospital Medical School, Zhejiang University, Hangzhou; Ruihua Xu, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou; Weijian Guo and Jin Li, Fudan University Shanghai Cancer Center; Tianshu Liu, Zhong Shan Hospital, Fudan University; Qi Li, Shanghai Jiaotong University affiliated First People's Hospital; Jin Li, Tongji University Affiliate Shanghai East Hospital, Shanghai; Chunmei Shi, Fujian Medical University Union Hospital, Fuzhou; Yuxian Bai, Third Affiliated Hospital of Harbin Medical University, Harbin; Feng Bi, West China Hospital, Sichuan University, Chengdu; Shukui Qin, Chinese People's Liberation Army Cancer Center of Nanjing Bayi Hospital, Nanjing; Changping Wu, The First People's Hospital of Changzhou, Changzhou; Dong Ma, Guangdong General Hospital, Guangzhou, Guangdong, China; Tae Won Kim, Asan Medical Center, University of Ulsan College of Medicine; Sae-Won Han, Seoul National University Hospital; Young Suk Park, Samsung Medical Center, Sungkyunkwan University School of Medicine; Joong Bae Ahn, Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University, College of Medicine, Seoul, Republic of Korea; Virote Sriuranpong, Chulalongkorn Hospital, Bangkok, Thailand; and Donghu Lin, Taiho Pharmaceutical, Tokyo, Japan., Qin S; Jianming Xu, Affiliated Hospital Cancer Centre, Academy of Military Medical Sciences (The 307 Hospital Cancer Centre of People's Liberation Army); Lin Shen, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing; Hongming Pan, Sir Run Run Shaw Hospital Medical School, Zhejiang University, Hangzhou; Ruihua Xu, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou; Weijian Guo and Jin Li, Fudan University Shanghai Cancer Center; Tianshu Liu, Zhong Shan Hospital, Fudan University; Qi Li, Shanghai Jiaotong University affiliated First People's Hospital; Jin Li, Tongji University Affiliate Shanghai East Hospital, Shanghai; Chunmei Shi, Fujian Medical University Union Hospital, Fuzhou; Yuxian Bai, Third Affiliated Hospital of Harbin Medical University, Harbin; Feng Bi, West China Hospital, Sichuan University, Chengdu; Shukui Qin, Chinese People's Liberation Army Cancer Center of Nanjing Bayi Hospital, Nanjing; Changping Wu, The First People's Hospital of Changzhou, Changzhou; Dong Ma, Guangdong General Hospital, Guangzhou, Guangdong, China; Tae Won Kim, Asan Medical Center, University of Ulsan College of Medicine; Sae-Won Han, Seoul National University Hospital; Young Suk Park, Samsung Medical Center, Sungkyunkwan University School of Medicine; Joong Bae Ahn, Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University, College of Medicine, Seoul, Republic of Korea; Virote Sriuranpong, Chulalongkorn Hospital, Bangkok, Thailand; and Donghu Lin, Taiho Pharmaceutical, Tokyo, Japan., Li Q; Jianming Xu, Affiliated Hospital Cancer Centre, Academy of Military Medical Sciences (The 307 Hospital Cancer Centre of People's Liberation Army); Lin Shen, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing; Hongming Pan, Sir Run Run Shaw Hospital Medical School, Zhejiang University, Hangzhou; Ruihua Xu, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou; Weijian Guo and Jin Li, Fudan University Shanghai Cancer Center; Tianshu Liu, Zhong Shan Hospital, Fudan University; Qi Li, Shanghai Jiaotong University affiliated First People's Hospital; Jin Li, Tongji University Affiliate Shanghai East Hospital, Shanghai; Chunmei Shi, Fujian Medical University Union Hospital, Fuzhou; Yuxian Bai, Third Affiliated Hospital of Harbin Medical University, Harbin; Feng Bi, West China Hospital, Sichuan University, Chengdu; Shukui Qin, Chinese People's Liberation Army Cancer Center of Nanjing Bayi Hospital, Nanjing; Changping Wu, The First People's Hospital of Changzhou, Changzhou; Dong Ma, Guangdong General Hospital, Guangzhou, Guangdong, China; Tae Won Kim, Asan Medical Center, University of Ulsan College of Medicine; Sae-Won Han, Seoul National University Hospital; Young Suk Park, Samsung Medical Center, Sungkyunkwan University School of Medicine; Joong Bae Ahn, Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University, College of Medicine, Seoul, Republic of Korea; Virote Sriuranpong, Chulalongkorn Hospital, Bangkok, Thailand; and Donghu Lin, Taiho Pharmaceutical, Tokyo, Japan., Wu C; Jianming Xu, Affiliated Hospital Cancer Centre, Academy of Military Medical Sciences (The 307 Hospital Cancer Centre of People's Liberation Army); Lin Shen, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing; Hongming Pan, Sir Run Run Shaw Hospital Medical School, Zhejiang University, Hangzhou; Ruihua Xu, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou; Weijian Guo and Jin Li, Fudan University Shanghai Cancer Center; Tianshu Liu, Zhong Shan Hospital, Fudan University; Qi Li, Shanghai Jiaotong University affiliated First People's Hospital; Jin Li, Tongji University Affiliate Shanghai East Hospital, Shanghai; Chunmei Shi, Fujian Medical University Union Hospital, Fuzhou; Yuxian Bai, Third Affiliated Hospital of Harbin Medical University, Harbin; Feng Bi, West China Hospital, Sichuan University, Chengdu; Shukui Qin, Chinese People's Liberation Army Cancer Center of Nanjing Bayi Hospital, Nanjing; Changping Wu, The First People's Hospital of Changzhou, Changzhou; Dong Ma, Guangdong General Hospital, Guangzhou, Guangdong, China; Tae Won Kim, Asan Medical Center, University of Ulsan College of Medicine; Sae-Won Han, Seoul National University Hospital; Young Suk Park, Samsung Medical Center, Sungkyunkwan University School of Medicine; Joong Bae Ahn, Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University, College of Medicine, Seoul, Republic of Korea; Virote Sriuranpong, Chulalongkorn Hospital, Bangkok, Thailand; and Donghu Lin, Taiho Pharmaceutical, Tokyo, Japan., Ma D; Jianming Xu, Affiliated Hospital Cancer Centre, Academy of Military Medical Sciences (The 307 Hospital Cancer Centre of People's Liberation Army); Lin Shen, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing; Hongming Pan, Sir Run Run Shaw Hospital Medical School, Zhejiang University, Hangzhou; Ruihua Xu, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou; Weijian Guo and Jin Li, Fudan University Shanghai Cancer Center; Tianshu Liu, Zhong Shan Hospital, Fudan University; Qi Li, Shanghai Jiaotong University affiliated First People's Hospital; Jin Li, Tongji University Affiliate Shanghai East Hospital, Shanghai; Chunmei Shi, Fujian Medical University Union Hospital, Fuzhou; Yuxian Bai, Third Affiliated Hospital of Harbin Medical University, Harbin; Feng Bi, West China Hospital, Sichuan University, Chengdu; Shukui Qin, Chinese People's Liberation Army Cancer Center of Nanjing Bayi Hospital, Nanjing; Changping Wu, The First People's Hospital of Changzhou, Changzhou; Dong Ma, Guangdong General Hospital, Guangzhou, Guangdong, China; Tae Won Kim, Asan Medical Center, University of Ulsan College of Medicine; Sae-Won Han, Seoul National University Hospital; Young Suk Park, Samsung Medical Center, Sungkyunkwan University School of Medicine; Joong Bae Ahn, Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University, College of Medicine, Seoul, Republic of Korea; Virote Sriuranpong, Chulalongkorn Hospital, Bangkok, Thailand; and Donghu Lin, Taiho Pharmaceutical, Tokyo, Japan., Lin D; Jianming Xu, Affiliated Hospital Cancer Centre, Academy of Military Medical Sciences (The 307 Hospital Cancer Centre of People's Liberation Army); Lin Shen, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing; Hongming Pan, Sir Run Run Shaw Hospital Medical School, Zhejiang University, Hangzhou; Ruihua Xu, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou; Weijian Guo and Jin Li, Fudan University Shanghai Cancer Center; Tianshu Liu, Zhong Shan Hospital, Fudan University; Qi Li, Shanghai Jiaotong University affiliated First People's Hospital; Jin Li, Tongji University Affiliate Shanghai East Hospital, Shanghai; Chunmei Shi, Fujian Medical University Union Hospital, Fuzhou; Yuxian Bai, Third Affiliated Hospital of Harbin Medical University, Harbin; Feng Bi, West China Hospital, Sichuan University, Chengdu; Shukui Qin, Chinese People's Liberation Army Cancer Center of Nanjing Bayi Hospital, Nanjing; Changping Wu, The First People's Hospital of Changzhou, Changzhou; Dong Ma, Guangdong General Hospital, Guangzhou, Guangdong, China; Tae Won Kim, Asan Medical Center, University of Ulsan College of Medicine; Sae-Won Han, Seoul National University Hospital; Young Suk Park, Samsung Medical Center, Sungkyunkwan University School of Medicine; Joong Bae Ahn, Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University, College of Medicine, Seoul, Republic of Korea; Virote Sriuranpong, Chulalongkorn Hospital, Bangkok, Thailand; and Donghu Lin, Taiho Pharmaceutical, Tokyo, Japan., Li J; Jianming Xu, Affiliated Hospital Cancer Centre, Academy of Military Medical Sciences (The 307 Hospital Cancer Centre of People's Liberation Army); Lin Shen, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing; Hongming Pan, Sir Run Run Shaw Hospital Medical School, Zhejiang University, Hangzhou; Ruihua Xu, Sun Yat-Sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou; Weijian Guo and Jin Li, Fudan University Shanghai Cancer Center; Tianshu Liu, Zhong Shan Hospital, Fudan University; Qi Li, Shanghai Jiaotong University affiliated First People's Hospital; Jin Li, Tongji University Affiliate Shanghai East Hospital, Shanghai; Chunmei Shi, Fujian Medical University Union Hospital, Fuzhou; Yuxian Bai, Third Affiliated Hospital of Harbin Medical University, Harbin; Feng Bi, West China Hospital, Sichuan University, Chengdu; Shukui Qin, Chinese People's Liberation Army Cancer Center of Nanjing Bayi Hospital, Nanjing; Changping Wu, The First People's Hospital of Changzhou, Changzhou; Dong Ma, Guangdong General Hospital, Guangzhou, Guangdong, China; Tae Won Kim, Asan Medical Center, University of Ulsan College of Medicine; Sae-Won Han, Seoul National University Hospital; Young Suk Park, Samsung Medical Center, Sungkyunkwan University School of Medicine; Joong Bae Ahn, Cancer Metastasis Research Center, Yonsei Cancer Center, Yonsei University, College of Medicine, Seoul, Republic of Korea; Virote Sriuranpong, Chulalongkorn Hospital, Bangkok, Thailand; and Donghu Lin, Taiho Pharmaceutical, Tokyo, Japan.

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2018 Feb 01; Vol. 36 (4), pp. 350-358. Date of Electronic Publication: 2017 Dec 07.