Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Donghoon Ahn"'
Autor:
Donghoon Ahn, Davide Provasi, Nguyen Minh Duc, Jun Xu, Leslie Salas-Estrada, Aleksandar Spasic, Min Woo Yun, Juyeong Kang, Dongmin Gim, Jaecheol Lee, Yang Du, Marta Filizola, Ka Young Chung
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106603- (2023)
Summary: G proteins are major signaling partners for G protein-coupled receptors (GPCRs). Although stepwise structural changes during GPCR–G protein complex formation and guanosine diphosphate (GDP) release have been reported, no information is ava
Externí odkaz:
https://doaj.org/article/13fa3b757a1e403a966e5cd0bd7f2e75
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
G protein-coupled receptors (GPCRs) can couple to more than one G protein subtype, and the coupling efficiency varies depending on the GPCR-G protein pair. Here authors use hydrogen/deuterium exchange mass spectrometry and mutagenesis to study the st
Externí odkaz:
https://doaj.org/article/07c8ff45757c4596b553213efaff5436
Autor:
Donghoon, Ahn, Ka Young, Chung
Publikováno v:
Sub-cellular biochemistry. 99
Heterotrimeric G proteins (G proteins) are essential cellular signaling proteins that mediate extracellular signals to achieve various cellular functions. G-protein-coupled receptors (GPCRs) are the major guanine nucleotide exchange factors (GEFs) th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a728a7dd44eb9b189087bb0749f0cbdf
https://pubmed.ncbi.nlm.nih.gov/36151379
https://pubmed.ncbi.nlm.nih.gov/36151379
Publikováno v:
The Biochemical journal. 479(17)
Heterotrimeric guanine nucleotide-binding proteins (G proteins) are composed of α, β, and γ subunits, and Gα has a GDP/GTP-binding pocket. When a guanine nucleotide exchange factor (GEF) interacts with Gα, GDP is released, and GTP interacts to G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45c81670e0fbe91b42e7d50c2c73eae
https://pubmed.ncbi.nlm.nih.gov/36000572
https://pubmed.ncbi.nlm.nih.gov/36000572
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Heterotrimeric G proteins are categorized into four main families based on their function and sequence, Gs, Gi/o, Gq/11, and G12/13. One receptor can couple to more than one G protein subtype, and the coupling efficiency varies depending on the GPCR-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858546f8081a7fce3965e8227c26e5c0
http://link.springer.com/article/10.1038/s41467-020-16975-2
http://link.springer.com/article/10.1038/s41467-020-16975-2
Autor:
Donghoon Ahn, Ka Young Chung
Publikováno v:
Subcellular Biochemistry ISBN: 9783031007927
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dc1651cfc4f65ed056cae208bc85a8d
https://doi.org/10.1007/978-3-031-00793-4_8
https://doi.org/10.1007/978-3-031-00793-4_8
Publikováno v:
Current opinion in structural biology. 69
The precise structural mechanism of G protein-coupled receptor (GPCR)-G protein coupling has been of significant research interest because it provides fundamental knowledge on cellular signaling and valuable information for GPCR-targeted drug develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7be36b26f582bd00acbbe96e73a93d
https://pubmed.ncbi.nlm.nih.gov/33975155
https://pubmed.ncbi.nlm.nih.gov/33975155
Autor:
Davide Provasi, Aleksandar Spasic, Nguyen Minh Duc, Yang Du, Donghoon Ahn, Jun Xu, KaYoung Chung, Marta Filizola
Publikováno v:
Biophysical Journal. 121:145a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d1a3a3c560149759239c915e76aeb70
https://doi.org/10.1016/j.bpj.2021.11.2000
https://doi.org/10.1016/j.bpj.2021.11.2000
Autor:
Wookyung Yu, Donghoon Ahn, Donghee Ham, Janbolat Ashim, Yejin Cho, Ka Young Chung, Hee Ryung Kim
Publikováno v:
Journal of Structural Biology. 213:107694
Heterotrimeric guanine nucleotide-binding proteins (G proteins) are composed of α, β, and γ subunits. Gα switches between guanosine diphosphate (GDP)-bound inactive and guanosine triphosphate (GTP)-bound active states, and Gβγ interacts with th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf85f4ccd899cc161a89082b9c336a0
https://doi.org/10.1016/j.jsb.2020.107694
https://doi.org/10.1016/j.jsb.2020.107694