Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Donghong A. Gao"'
Autor:
Steven J. Taylor, Asitha Abeywardane, Shuang Liang, Zhaoming Xiong, John R. Proudfoot, Bennett Sandy Farmer, Donghong A. Gao, Alexander Heim-Riether, Lana Louise Smith-Keenan, Ingo Muegge, Yang Yu, Qiang Zhang, Donald Souza, Mark Panzenbeck, Daniel Goldberg, Melissa Hill-Drzewi, Mariana Margarit, Brandon Collins, John Xiang Li, Ljiljana Zuvela-Jelaska, Jun Li, Neil A. Farrow
Publikováno v:
ACS Omega, Vol 6, Iss 29, Pp 18635-18650 (2021)
Externí odkaz:
https://doaj.org/article/28925716e0524cb7af79c7a4126b692b
Publikováno v:
Organic Process Research & Development. 25:632-641
Herein, a scalable and practical process to prepare trans-4-fluorocyclohexylamine hydrochloride (1a) is described. By exploitation of the embedded gem-difluoride motif in the commercially available...
Autor:
Christopher J. Welch, Shagawa Tomohiro, Kevin Joseph Barry, Mengling Wong, Donghong A. Gao, Iriki Takayuki, Eric T. Manning, Masami Tomita, Nobumitsu Fukushima, Timothy Lee, William Farrell, Benjamin Hritzko, Masayuki Nishimura, Larry Miller, Thomas J. Moran, Robert P. DePianta, Eric P. Seest, Lisa Schaffter, Heewon Lee, Lisa Nogle, Loanne Chung, Yingru Zhang, Katsuhiro Tanaka, Shuping Dong, Michiaki Owa, William Leister, Takeshi Bamba, Meenakshi Goel, Mirlinda Biba, Andy Sasaki, Frank Riley, James Paulson, Douglas B. Moore, Jimmy O. DaSilva, Anne Akin
Publikováno v:
Organic Process Research & Development. 24:1271-1280
Precompetitive collaborations on the development of new enabling technologies for conducting pharmaceutical research and development are becoming increasingly popular as pharmaceutical companies re...
Autor:
Sergei Tcyrulnikov, Joshua D. Sieber, Nitinchandra D. Patel, Kendricks S. Lao, Marisa C. Kozlowski, Soumik Biswas, Chris H. Senanayake, Nelu Grinberg, Krishnaja Duvvuri, Neil K. Garg, B. Frank Gupton, Daniel Rivalti, Jinhua J. Song, Scott Pennino, Bo Qu, Heewon Lee, Donghong A. Gao, Yongda Zhang, Hari P. R. Mangunuru, Nizar Haddad, Bryan J. Simmons, Keith R. Fandrick
Publikováno v:
ACS Catalysis. 8:10190-10209
Metal-catalyzed cross-coupling reactions are extensively employed in both academia and industry for the synthesis of biaryl derivatives for applications to both medicine and material science. Application of these methods to prepare tetra-ortho-substi
Autor:
Nitinchandra Dahyabhai, Patel, Joshua D, Sieber, Sergei, Tcyrulnikov, Bryan J, Simmons, Daniel, Rivalti, Krishnaja, Duvvuri, Yongda, Zhang, Donghong A, Gao, Keith R, Fandrick, Nizar, Haddad, Kendricks So, Lao, Hari Prasad Reddy, Mangunuru, Soumik, Biswas, Bo, Qu, Nelu, Grinberg, Scott, Pennino, Heewon, Lee, Jinhua J, Song, B Frank, Gupton, Neil K, Garg, Marisa C, Kozlowski, Chris H, Senanayake
Publikováno v:
ACS catalysis. 8(11)
Metal-catalyzed cross-coupling reactions are extensively employed in both academia and industry for the synthesis of biaryl derivatives for applications to both medicine and material science. Application of these methods to prepare tetra-ortho-substi
Autor:
Nitinchandra D. Patel, Joshua D. Sieber, Sergei Tcyrulnikov, Bryan J. Simmons, Daniel Rivalti, Krishnaja Duvvuri, Yongda Zhang, Donghong A. Gao, Keith R. Fandrick, Nizar Haddad, Kendricks So Lao, Hari P. R. Mangunuru, Soumik Biswas, Bo Qu, Nelu Grinberg, Scott Pennino, Heewon Lee, Jinhua J. Song, B. Frank Gupton, Neil K. Garg, Marisa C. Kozlowski, Chris H. Senanayake
Publikováno v:
ACS Catalysis. 9:1319-1319
Autor:
Xudong Wei, Jolaine Savoie, Bruce Z. Lu, Mckibben Bryan, Keith R. Fandrick, Heewon Lee, Jean-Nicolas Desrosiers, Melissa A. Herbage, Frank Roschangar, Zhibin Li, Donghong A. Gao, Chris H. Senanayake, Jonathan T. Reeves, Nina C. Gonnella, Maurice A. Marsini, C. Avery Sader, Jianwen Cui
Publikováno v:
Organic letters. 17(22)
A general, scalable, and highly diastereoselective aziridination of N-tert-butanesulfinyl ketimino esters is described. The methodology has been utilized to provide straightforward access to previously unobtainable, biologically relevant α-quaternar
Autor:
E. Michael August, Lana Louise Smith Keenan, Jun Li, S. Mariana Margarit, Alexander Heim-Riether, Hans-Dieter Junker, Kathleen Haverty, Neil A. Farrow, Brandon Collins, Bennett T. Farmer, Thomas Neumann, Shuang Liang, John R. Proudfoot, Renate Sekul, Qiang Zhang, Donghong Amy Gao, Steven John Taylor, Zhaoming Xiong, Neil Moss, Melissa Hill-Drzewi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5321-5324
Discovery and optimization of potency and selectivity of a non-Zn-chelating MMP-13 inhibitor with the aid of protein co-crystal structural information is reported. This inhibitor was observed to have a binding mode distinct from previously published
Autor:
Ming-Hong Hao, Andre White, Edward Pack, Zhaoming Xiong, Daniel R. Goldberg, Donghong Amy Gao, Brian Werneburg, Donna Skow, Derek Cogan, Thomas Trieselmann, Neil Moss, Chris Pargellis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1994-1999
Chemistry has been developed to specifically functionalize two structurally similar classes of indole-based MK2 inhibitors at positions prompted by a combination of X-ray crystallographic and computer assisted drug design. A gain in molecular potency
Autor:
Shuang Liang, Kathleen Haverty, Donghong Amy Gao, Jun Li, Xiang Li, Sabine Schlyer, Alexander Heim-Riether, Melissa Hill-Drzewi, Steven John Taylor, Steluta Mariana Margarit, Lana Louise Smith Keenan, Neil Moss, Nelamangala V. Nagaraja, Xianhua Cao, Dieter Wiedenmayer, Neil A. Farrow, Kyle E. Harrington, Brandon Collins, E. Michael August, Leonard Ciccarelli, Rene Roman, Bernd Wellenzohn, Zhaoming Xiong, Laura Amodeo, John R. Proudfoot
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(17)
SAR studies to improve the selectivity and metabolic stability of a class of recently discovered MMP-13 inhibitors are reported. Improved selectivity was achieved by modifying interactions with the S1' pocket. Metabolic stability was improved through