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Potent non-peptidic dual inhibitors of endothelin-converting enzyme and neutral endopeptidase 24.11

Autor: Michael A. Moskal, Dongchu Wei, Lisa B. Stamford, Jenny Tan, Clive Gideon Diefenbacher, Eli M. Wallace, L. Blanchard, Paula Savage, Stéphane De Lombaert, Hoyer Denton W, Arco Y. Jeng

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 7:1059-1064

Structural modifications of CGS 26303, a non-peptidic α-aminophosphonate dual ECE/NEP inhibitor lead, were performed to maximize inhibition of recombinant human ECE-1, while maintaining strong NEP inhibition. Specifically, substitution of the α-ami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd00a8276a9bf7ab487e88f10b5bf21e
https://doi.org/10.1016/s0960-894x(97)00159-5

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Convenient halodeamination and hydrodeamination of primary amines

Autor: Frank S. Guziec, Dongchu Wei

Publikováno v: The Journal of Organic Chemistry. 57:3772-3776

Treatment of p-toluenesulfomides of primary amines with 2 equiv of chloroamine at room temperature in the presence of base leads to reductive deamination. If excess chloroamine present, the corresponding or aryl halides are obtained instead in good y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1fc1b6913ee94499db04972355cfc19
https://doi.org/10.1021/jo00040a010

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Base-promoted oxygenation of N-substituted-N-tosylhydrazines -- a convenient route to hydroxydeamination of primary amines

Autor: Dongchu Wei, Frank S. Guziec

Publikováno v: Tetrahedron Letters. 33:7465-7468

Treatment of 1-substituted-1-tosylhydrazines with KOH in refluxing ethanol in the presence of atmospheric oxygen affords the corresponding alcohols in high yield. This reaction, proceeding via ethanol reduction of an intermediate hydroperoxide, provi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bfdfe11a0d5d2fc5bd29c111547cffc5
https://doi.org/10.1016/s0040-4039(00)60796-7

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Design and synthesis of potent thiol-based inhibitors of endothelin converting enzyme-1

Autor: Arco Y. Jeng, Ying Qiao, Paula Savage, Michael A. Moskal, Michael E. Beil, Angelo J. Trapani, Fariborz Firooznia, Hoyer Denton W, Cynthia A. Fink, Dongchu Wei, David Symonsbergen

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 10:2037-2039

Through directed screening of compounds prepared as metalloprotease inhibitors a compound, CGS 30084 , that had potent endothelin converting enzyme-1 (ECE-1) in vitro inhibitory activity (IC 50 =77 nM) was identified. Herein we report the synthesis a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb38dc1440f5ad74bbac9edd81f558df
https://doi.org/10.1016/s0960-894x(00)00403-0

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Conversion of N-substituted N-sulfonylhydrazines into hydroperoxides - a new synthetic route to hydroperoxides via hydroperoxydeamination

Autor: Antonio Munoz, Migdalia Alvarado, Luis R. Collazo, Wei Xiao Hu, Frank S. Guziec, Dongchu Wei

Publikováno v: The Journal of Organic Chemistry. 58:6169-6170

N-Substituted Nsulfonylhydrazines, obtained by amination of primary amine sulfonamides, can be readily oxygenated by atmospheric oxygen under basic conditions below room temperature to cleanly afford alkyl hydroperoxides in god yield

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6136800194a73f90efba214d0f2dac95
https://doi.org/10.1021/jo00075a003

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