Zobrazeno 1 - 10
of 359
pro vyhledávání: '"Dongchon Kang"'
Autor:
Masamune Aihara, Yasuhiro Gotoh, Saki Shirahama, Yuichi Matsushima, Takeshi Uchiumi, Dongchon Kang, Tetsuya Hayashi
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract In gram-negative bacteria, IS26 often exists in multidrug resistance (MDR) regions, forming a pseudocompound transposon (PCTn) that can be tandemly amplified. It also generates a circular intermediate called the “translocatable unit (TU)
Externí odkaz:
https://doaj.org/article/3cd5b1d90c084cf78cdd208aa25d172a
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109735- (2024)
Summary: Lysosomes, the hub of metabolic signaling, are associated with various diseases and participate in autophagy by supplying nutrients to cells under nutrient starvation. However, their function and regulation under glucose starvation remain un
Externí odkaz:
https://doaj.org/article/c0083f3530d141338dd44d317e895de3
Autor:
Kentaro Nakashima, Yuya Kunisaki, Kentaro Hosokawa, Kazuhito Gotoh, Hisayuki Yao, Ryosuke Yuta, Yuichiro Semba, Jumpei Nogami, Yoshikane Kikushige, Patrick S. Stumpf, Ben D. MacArthur, Dongchon Kang, Koichi Akashi, Shouichi Ohga, Fumio Arai
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Protection of telomeres 1a (POT1a) is a telomere binding protein. A decrease of POT1a is related to myeloid-skewed haematopoiesis with ageing, suggesting that protection of telomeres is essential to sustain multi-potency. Since mesenchymal s
Externí odkaz:
https://doaj.org/article/e55a84a5ea34472ba25f72989b580bf5
Autor:
Kenji Miki, Mikako Yagi, Naoki Noguchi, Yura Do, Ryosuke Otsuji, Daisuke Kuga, Dongchon Kang, Koji Yoshimoto, Takeshi Uchiumi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Glioblastoma, a malignant tumor, has no curative treatment. Recently, mitochondria have been considered a potential target for treating glioblastoma. Previously, we reported that agents initiating mitochondrial dysfunction were effective und
Externí odkaz:
https://doaj.org/article/d6c411e507084146b2b25e1ac2ed7142
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-13 (2022)
Abstract Glioblastoma is a difficult-to-cure disease owing to its malignancy. Under normal circumstances, cancer is dependent on the glycolytic system for growth, and mitochondrial oxidative phosphorylation (OXPHOS) is not well utilized. Here, we inv
Externí odkaz:
https://doaj.org/article/7ba0da91d2b844a6b7d7f1fb8014ae2c
Autor:
Shun Fujinuma, Hirokazu Nakatsumi, Hideyuki Shimizu, Shigeaki Sugiyama, Akihito Harada, Takeshi Goya, Masatake Tanaka, Motoyuki Kohjima, Masatomo Takahashi, Yoshihiro Izumi, Mikako Yagi, Dongchon Kang, Mari Kaneko, Mayo Shigeta, Takeshi Bamba, Yasuyuki Ohkawa, Keiichi I. Nakayama
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112530- (2023)
Summary: Nonalcoholic fatty liver disease (NAFLD) is a chronic metabolic disorder caused by overnutrition and can lead to nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). The transcription factor Forkhead box K1 (FOXK1) is impl
Externí odkaz:
https://doaj.org/article/c7dcb663cc3c4ff9a5e0de545632c9b9
Autor:
Shigehiro Tsukahara, Masaki Shiota, Dai Takamatsu, Shohei Nagakawa, Takashi Matsumoto, Ryo Kiyokoba, Mikako Yagi, Daiki Setoyama, Nozomi Noda, Shinya Matsumoto, Tetsutaro Hayashi, Alberto Contreras-Sanz, Peter C. Black, Junichi Inokuchi, Kenichi Kohashi, Yoshinao Oda, Takeshi Uchiumi, Masatoshi Eto, Dongchon Kang
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Chemotherapy is a standard therapy for muscle-invasive bladder cancer (MIBC). However, genomic alterations associated with chemotherapy sensitivity in MIBC have not been fully explored. This study aimed to investigate the genomic landscape o
Externí odkaz:
https://doaj.org/article/592f640d5f66404789c46f9398fa543d
Autor:
Ryo Kiyokoba, Takeshi Uchiumi, Mikako Yagi, Takahiro Toshima, Shigehiro Tsukahara, Yasuyuki Fujita, Kiyoko Kato, Dongchon Kang
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Fetal growth restriction (FGR) and pre-eclampsia with fetal growth restriction (PE/FGR) are high-risk perinatal diseases that may involve high levels of human chorionic gonadotropin (hCG) and mitochondrial dysfunction. However, little is kno
Externí odkaz:
https://doaj.org/article/0b8a81fa9cad46f7a4bdb0afbeebc1de
Autor:
Daiki Setoyama, Ho Yeop Lee, Ji Sun Moon, Jingwen Tian, Yea Eun Kang, Ju Hee Lee, Minho Shong, Dongchon Kang, Hyon‐Seung Yi
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 1, Pp 355-367 (2022)
Abstract Background Thyroid hormone excess induces protein energy wasting, which in turn promotes muscle weakness and bone loss in patients with Graves' disease. Although most studies have confirmed a relationship between thyrotoxicosis and muscle dy
Externí odkaz:
https://doaj.org/article/4bbc8a6c686f49bbb976dd29f2aa4932
Autor:
Masakazu Fujii, Daiki Setoyama, Kazuhito Gotoh, Yushi Dozono, Mikako Yagi, Masataka Ikeda, Tomomi Ide, Takeshi Uchiumi, Dongchon Kang
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104889- (2022)
Summary: The occurrence of diet-induced obesity has been increasing worldwide and has become a major health concern. Mitochondria are densely distributed in brown adipose tissue and are involved in lipid consumption. Therefore, increasing energy expe
Externí odkaz:
https://doaj.org/article/d94000035ebc4e8583b49ba634ecd832