Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Dong-ke Yu"'
Publikováno v:
Journal of Pharmacy and Pharmacology. 73:986-995
Objectives To explore the potential molecular mechanism underlying the effect of green tea extract (TE), rich in tea polyphenols (TPs), on improving alcohol-induced liver injury. Methods Mice were intragastrically treated with 50% (v/v) alcohol admin
Autor:
Hongwei He, Mei Zhu, Qi Shan, Guoning Zhang, Zhen-Ning Lu, Zhao Yue, Shang-Jiu Hu, Juxian Wang, Dong‐ke Yu
Publikováno v:
Bioorganicmedicinal chemistry. 49
Liver fibrosis is one of the most common pathological consequences of chronic liver diseases (CLD). To develop effective antifibrotic strategies, a novel class of 1-(substituted phenyl)-1,8-naphthalidine-3-carboxamide derivatives were designed and sy
Autor:
Rong-Guang Shao, Dong-ke Yu, Maoxu Ge, Hong-Tao Liu, Juxian Wang, Wei-xiao Niu, Yi-xuan Zhang, Hongwei He, Shi-Ying Cai, Zhang Na, Ren Jinfeng, Yucheng Wang
Publikováno v:
Acta Pharmacol Sin
The manipulation of bile acid (BA) homeostasis by blocking the ileal apical Na(+)-dependent bile salt transporter (ASBT/SLC10A2) may have therapeutic effects in nonalcoholic fatty liver disease. We developed a novel ASBT inhibitor, an N-(3,4-o-dichlo
Autor:
Shengtao Ye, Xiaoyun Zhu, Meihui Zhang, Ting Yang, Ling-Yi Kong, Xin-lin Chen, Yingrong Leng, Dong‐ke Yu, Hao Zhang, Jian-Guang Luo, Jie Li, Yanqiu Zhang
Publikováno v:
British journal of pharmacologyREFERENCES. 178(17)
Background and purpose Liver fibrosis is one of the leading causes of morbidity and mortality worldwide but lacks any acceptable therapy. The transcription factor glioma-associated oncogene homologue 1 (GLI1) is a potentially important therapeutic ta
Publikováno v:
Experimental neurology. 326
Epidemiological studies suggest that chronic periodontitis (CP) is closely associated with the incidence and progression of cognitive impairment. The present study investigated the causal relationship between CP and cognitive decline and the underlyi
Autor:
Dong‐ke Yu, Hong-Tao Liu, Zhen‐ning Lu, Wei-xiao Niu, Ge Maoxu, He Hongwei, Rong-Guang Shao, Bao Yunyang, Na Zhang, Rui Huang
Publikováno v:
Br J Pharmacol
Background and purpose This study investigates the antifibrotic activities and potential mechanisms of costunolide (COS), a natural sesquiterpene compound. Experimental approach Rats subjected to bile duct ligation and mice challenged with CCl4 were
Publikováno v:
Journal of Pharmacy & Pharmacology; Jul2021, Vol. 73 Issue 7, p986-995, 10p
Publikováno v:
YAKUGAKU ZASSHI. 129:855-859
Antithrombotic therapy has become an important goal for the treatment of ischemic disorders such as cerebral ischemia. Our recent studies found that Z-ligustilide (LIG), a characterized 3-n-alkylphthalide constituent of Radix Angelica sinensis essent
Autor:
Wei, Ji, Yu-Yun, Chen, Jun-Rong, Du, Dong-Ke, Yu, Xiao-Yuan, Zheng, Fang, Yang, Chuan-Xing, Yu, De-Shan, Li, Chang-Yi, Zhao, Kui-Yun, Qiao
Publikováno v:
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 40(4)
To investigate the effect of low molecular weight potassium alginate (L-PA) on blood pressures in spontaneously hypertensive rats (SHRs) and its pharmacokinetics characteristics in mice.The systolic blood pressure (SBP) was measured by tail-cuff meth
Autor:
Wei Ji, Chuan-Xing Yu, Yu-Yun Chen, Kui-yun Qiao, Yao He, De-Shan Li, Dong-Ke Yu, Jun-Rong Du, Chang-yi Zhao
Publikováno v:
Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 64(4)
Available evidence indicates that brown algae may be beneficial for the treatment of high blood pressure. Our recent study demonstrated that low molecular mass potassium alginate (L-PA), one of the major polysaccharides extracted from brown algae, de