Identification of a novel PHGDH covalent inhibitor by chemical proteomics and phenotypic profiling

Autor: Jian-Guang Luo, Tianyu Zhu, Chen Chen, Yi Zhang, Hao Zhang, Dong-Rong Zhu, Xiao-Qin Liu, Ling-Yi Kong, Chao Han, Sifang Wu

Publikováno v: Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 246-261 (2022)
Acta Pharmaceutica Sinica. B

The first rate-limiting enzyme of the serine synthesis pathway (SSP), phosphoglycerate dehydrogenase (PHGDH), is hyperactive in multiple tumors, which leads to the activation of SSP and promotes tumorigenesis. However, only a few inhibitors of PHGDH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3543b6d3266f2b136393cdedb4c3da23
http://www.sciencedirect.com/science/article/pii/S2211383521002203

Osteosarcoma cell proliferation suppression via SHP-2-mediated inactivation of the JAK/STAT3 pathway by tubocapsenolide A

Autor: Jian-Guang Luo, Si-Bei Wang, Chen Chen, Dong-Rong Zhu, Hao Zhang, Xiao-Qin Liu, Ling-Yi Kong, Jiang-Min Zhu

Publikováno v: Journal of Advanced Research

Graphical abstract
Introduction Previously, we have reported a withanolide-type steroid, named tubocapsenolide A (TA), which shows potent anti-proliferative activity in several cancer cell lines. However, its inhibitory effect on the Janus kinas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d584daf9fd70d0018ded7a19e8398d8e
https://doi.org/10.1016/j.jare.2021.06.004

Taxodisones A and B: bioactive C30-terpenes with new skeletons from Taxodium distichum and their biosynthetic origin

Autor: Chao Han, Ling-Nan Li, Jian-Guang Luo, Xiao-Qin Liu, Ling-Yi Kong, Dong-Rong Zhu, Mei-Hui Zhang, Bin Lin, Wen-Li Wang, Chen Chen

Publikováno v: Chemical Communications. 56:3329-3332

Taxodisones A and B, C30-terpenes with an unprecedented tetracyclo[12.4.0.0.2,709,14]octodecane core, were isolated from the seeds of Taxodium distichum. Their structures, including their configurations, were unambiguously determined. Their biomimeti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19e2446b7d7ef5fb95160bb19d58074d
https://doi.org/10.1039/c9cc09433d

Taicrypnacids A and B, a Pair of C37 Heterodimeric Diterpenoid Stereoisomers from Taiwania cryptomerioides

Autor: Tianyu Zhu, Jian-Guang Luo, Ling-Yi Kong, Dong-Rong Zhu, Feiyan Liu, Wen-Li Wang, Chao Han, Ling-Nan Li, Chen Chen

Publikováno v: Journal of Natural Products. 82:2087-2093

Two uncommon C37 heterodimeric diterpenoids, taicrypnacids A (1) and B (2), and a known labdane-type diterpenoid (3) were isolated from the leaves of Taiwania cryptomerioides. Several techniques, such as comprehensive spectroscopic analysis, chemical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16ed6732afeb35eb27aaed94ed2334b2
https://doi.org/10.1021/acs.jnatprod.8b00815

Downregulation of Aquaporin 3 Mediated the Laxative Effect in the Rat Colon by a Purified Resin Glycoside Fraction from Pharbitis Semen

Autor: Jian-Guang Luo, Chen Chen, Ling-Yi Kong, Dong-Rong Zhu, Lijuan Bai

Publikováno v: Evidence-Based Complementary and Alternative Medicine, Vol 2019 (2019)
Evidence-based Complementary and Alternative Medicine : eCAM

Background. Pharbitis Semen, the seeds ofPharbitis nil, is widely used as a traditional purgative medicine in China, Korea, and Japan. This study investigated the laxative effects of a purified resin glycoside fraction obtained in our previous study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf3e5894a6f7e0e37ae8183cf5902270
https://doi.org/10.1155/2019/9406342