Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Dong-Jin Hwang"'
Autor:
Mousumi Mandal, Ahmed Rakib, Md Abdullah Al Mamun, Santosh Kumar, Frank Park, Dong-Jin Hwang, Wei Li, Duane D. Miller, Udai P. Singh
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117379- (2024)
Scope: Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory condition of unknown etiology, although recent evidence suggests that it is caused by an excessive immune response to mucosal antigens. We determined the anti-inflammatory p
Externí odkaz:
https://doaj.org/article/68627205b8b144398d54d7ad824ae8ff
Autor:
Sarah Asemota, Wendy Effah, Kirsten L. Young, Jeremiah Holt, Linnea Cripe, Suriyan Ponnusamy, Thirumagal Thiyagarajan, Dong-Jin Hwang, Yali He, Keely Mcnamara, Daniel Johnson, Yinan Wang, Brandy Grimes, Yekta Khosrosereshki, T.J. Hollingsworth, Martin D. Fleming, Frances E. Pritchard, Ashley Hendrix, Farhan Khan, Meiyun Fan, Liza Makowski, Zheng Yin, Hironobu Sasano, D. Neil Hayes, Lawrence M. Pfeffer, Duane D. Miller, Ramesh Narayanan
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113461- (2023)
Summary: Triple-negative breast cancer (TNBC) is an aggressive subtype with no targeted therapeutics. The luminal androgen receptor (LAR) subtype constitutes 15% of TNBC and is enriched for androgen receptor (AR) and AR target genes. Here, we show th
Externí odkaz:
https://doaj.org/article/ac241ea52bf347e5b56f2020cc95e398
Autor:
Michael L. Mohler, Arunima Sikdar, Suriyan Ponnusamy, Dong-Jin Hwang, Yali He, Duane D. Miller, Ramesh Narayanan
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 2124 (2021)
Traditional endocrine therapy for prostate cancer (PCa) has been directed at suppression of the androgen receptor (AR) signaling axis since Huggins et al. discovered that diethylstilbestrol (DES; an estrogen) produced chemical castration and PCa tumo
Externí odkaz:
https://doaj.org/article/e34675d13eda4419935a324e78a0a1c0
Autor:
Min Pi, Karan Kapoor, Ruisong Ye, Dong-Jin Hwang, Duane D Miller, Jeremy C Smith, Jerome Baudry, L Darryl Quarles
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195980 (2018)
New insights into G protein coupled receptor regulation of glucose metabolism by β-cells, skeletal muscle and liver hepatocytes identify GPRC6A as a potential therapeutic target for treating type 2 diabetes mellitus (T2D). Activating GPRC6A with a s
Externí odkaz:
https://doaj.org/article/41e46d649cdc4ea6bc5090886a6ba655
Publikováno v:
Molecules, Vol 21, Iss 11, p 1468 (2016)
Extensive research over the last decade has resulted in a number of highly potent tubulin polymerization inhibitors acting either as microtubule stabilizing agents (MSAs) or microtubule destabilizing agents (MDAs). These inhibitors have potent cytoto
Externí odkaz:
https://doaj.org/article/7ed2392200b14ed8a91eefefb88d763f
Autor:
Wei Li, Duane D. Miller, James T. Dalton, Frank Park, Jinliang Yang, Qiang Chen, David Hamilton, Terry Costello, Yi Xue, Dong-Jin Hwang, Yuxi Wang, Kinsie E. Arnst
Antimitotics that target tubulin are among the most useful chemotherapeutic drugs, but their clinical activity is often limited by the development of multidrug resistance. We recently discovered the novel small-molecule DJ101 as a potent and metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e0a69e4592f7ff89f41df78eec1c2d
https://doi.org/10.1158/0008-5472.c.6509366.v1
https://doi.org/10.1158/0008-5472.c.6509366.v1
Autor:
Ramesh Narayanan, Duane D. Miller, James T. Dalton, Tudor Moldoveanu, Wayne D. Tilley, Christopher Ledbetter, Robert W. Wake, Geetika Singh, Jayaprakash Pagadala, Charles B. Duke, Iain J. McEwan, Luke A. Selth, Yali He, Dong-Jin Hwang, Kate Watts, Thirumagal Thiyagarajan, Christopher C. Coss, Suriyan Ponnusamy
Androgen receptor (AR) mediates the growth of prostate cancer throughout its course of development, including in abnormal splice variants (AR-SV)-driven advanced stage castration-resistant disease. AR stabilization by androgens makes it distinct from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4eabed8b39f4c2e494de62021040cfc
https://doi.org/10.1158/0008-5472.c.6509612.v1
https://doi.org/10.1158/0008-5472.c.6509612.v1
Autor:
Ramesh Narayanan, Duane D. Miller, Iain J. McEwan, Robert H. Getzenberg, Lawrence M. Pfeffer, Ziyun Du, Daniel Johnson, Elias Fernandez, Bobby G. Sumpter, Vera Bocharova, Rene Houtman, Thirumagal Thiyagarajan, Dong-Jin Hwang, Yali He, Suriyan Ponnusamy
Suppl. Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9054e8abc24980aa48961a1579ce4617
https://doi.org/10.1158/1078-0432.22472238.v1
https://doi.org/10.1158/1078-0432.22472238.v1
Autor:
Ramesh Narayanan, Duane D. Miller, James T. Dalton, Tudor Moldoveanu, Wayne D. Tilley, Christopher Ledbetter, Robert W. Wake, Geetika Singh, Jayaprakash Pagadala, Charles B. Duke, Iain J. McEwan, Luke A. Selth, Yali He, Dong-Jin Hwang, Kate Watts, Thirumagal Thiyagarajan, Christopher C. Coss, Suriyan Ponnusamy
Captions for supporting data and detailed methods for chemical synthesis and standard biochemical assays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0c6b7f62ec6c2aaa514bd22ff097be
https://doi.org/10.1158/0008-5472.22416659.v1
https://doi.org/10.1158/0008-5472.22416659.v1
Autor:
Ramesh Narayanan, Duane D. Miller, James T. Dalton, Tudor Moldoveanu, Wayne D. Tilley, Christopher Ledbetter, Robert W. Wake, Geetika Singh, Jayaprakash Pagadala, Charles B. Duke, Iain J. McEwan, Luke A. Selth, Yali He, Dong-Jin Hwang, Kate Watts, Thirumagal Thiyagarajan, Christopher C. Coss, Suriyan Ponnusamy
S1: SARDs inhibit AR mutant activity. S2: UT-155-dependent degradation is selective to the AR. S3: UT-155 degrades wildtype and Y267 phospho mutant ARs. S4. UT-155 inhibits AR ABCD and AR-V7 induced activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09eeb72c5238a95956bab975ce3664b4
https://doi.org/10.1158/0008-5472.22416665.v1
https://doi.org/10.1158/0008-5472.22416665.v1