Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Dong-Hun Woo"'
Autor:
Myeongjin Song, Da Bin Choi, Jeong Suk Im, Ye Na Song, Ji Hyun Kim, Hanbyeol Lee, Jieun An, Ami Kim, Hwan Choi, Joon-Chul Kim, Choongseong Han, Young Keul Jeon, Sung Joon Kim, Dong-Hun Woo
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-13 (2024)
Abstract Heart disease involves irreversible myocardial injury that leads to high morbidity and mortality rates. Numerous cell-based cardiac in vitro models have been proposed as complementary approaches to non-clinical animal research. However, most
Externí odkaz:
https://doaj.org/article/b2975d96d1a74e2eb82a26faa70d7b1c
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116511- (2024)
Human iPSC-derived cardiac organoids (hiPSC-COs) for cardiotoxicity drug testing via the variety of cell lines and unestablished protocols may lead to differences in response results due to a lack of criteria for generation period and size. To ensure
Externí odkaz:
https://doaj.org/article/c179a344835e409a9f79fc8383bcd184
Autor:
Hye-Min Jeon, Yong Jae Shin, Jaehyun Lee, Nakho Chang, Dong-Hun Woo, Won Jun Lee, Dayna Nguyen, Wonyoung Kang, Hee Jin Cho, Heekyoung Yang, Jin-Ku Lee, Jason K. Sa, Yeri Lee, Dong Geon Kim, Benjamin W. Purow, Yeup Yoon, Do-Hyun Nam, Jeongwu Lee
Publikováno v:
JCI Insight, Vol 8, Iss 21 (2023)
Glioblastoma (GBM) is the most lethal brain cancer with a dismal prognosis. Stem-like GBM cells (GSCs) are a major driver of GBM propagation and recurrence; thus, understanding the molecular mechanisms that promote GSCs may lead to effective therapeu
Externí odkaz:
https://doaj.org/article/8ea1cbbe2cb049948a953837f0efb51e
Autor:
Hyo Jin Kim, Gyeongmin Kim, Kyun Yoo Chi, Hyemin Kim, Yu Jin Jang, Seongyea Jo, Jihun Lee, Youngseok Lee, Dong-Hun Woo, Choongseong Han, Sang Kyum Kim, Han-Jin Park, Jong-Hoon Kim
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Background The generation of liver organoids recapitulating parenchymal and non-parenchymal cell interplay is essential for the precise in vitro modeling of liver diseases. Although different types of multilineage liver organoids (mLOs) have
Externí odkaz:
https://doaj.org/article/33f9d3996cf44d998c0860823c16d166
Autor:
Jung-Hyun Kim, Geun Ho An, Ji-Young Kim, Roya Rasaei, Woo Jin Kim, Xiong Jin, Dong-Hun Woo, Choongseong Han, Se-Ran Yang, Jong-Hoon Kim, Seok-Ho Hong
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-12 (2021)
Abstract Detailed understanding of the pathogenesis and development of effective therapies for pulmonary fibrosis (PF) have been hampered by lack of in vitro human models that recapitulate disease pathophysiology. In this study, we generated alveolar
Externí odkaz:
https://doaj.org/article/483430aa795245aa84ac8a0bb56e723f
Autor:
Hanbyeol Lee, Jeong Suk Im, Da Bin Choi, Jieun An, Su-Bin Kim, Seunghee Yeon, Seulgi Yoon, Dong-Hun Woo
Publikováno v:
Organoid, Vol 2 (2022)
Background Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs) offer a promising source for heart disease modeling and drug screening. Recent developments in organoid technology have made it possible to study how hiPSC-derived CM
Externí odkaz:
https://doaj.org/article/e115121e193e48ccadb251bca756feba
Publikováno v:
Organoid, Vol 1 (2021)
Animal models have been standard methods for non-clinical research in drug development for decades. However, many drugs that have shown satisfactory results in non-clinical studies have failed in the clinical stage, presumably because animal data are
Externí odkaz:
https://doaj.org/article/9daf5f1322a0434dbdaae1691a0b765c
Autor:
Jeong Seong Kim, Seon In Hwang, Jung Lim Ryu, Hee Su Hong, Ji-Min Lee, Sang Min Lee, Xiong Jin, Choongseong Han, Jong-Hoon Kim, Jaeseok Han, Man-Ryul Lee, Dong-Hun Woo
Publikováno v:
Stem Cell Research, Vol 43, Iss , Pp - (2020)
Endoplasmic reticulum stress (ER stress) leads an unfolded protein response (UPR) which results in internal cellular responses such as proteostasis and protein clearance. Recently, several reports demonstrated that the ER stress in stem cells could a
Externí odkaz:
https://doaj.org/article/6e4318bca3aa4a85a8f4e035db6004ed
Publikováno v:
Stem Cell Research, Vol 31, Iss , Pp 117-121 (2018)
Single nucleotide polymorphisms (SNPs) in cytochrome P450 (CYP) isoenzymes alter drug metabolism and pharmacodynamics. In particular, several SNPs within CYPs decrease CYP activities, resulting in a high plasma concentration of drugs and increasing a
Externí odkaz:
https://doaj.org/article/af72d0df07a34a1d960321d3da634708
Publikováno v:
Stem Cell Research, Vol 27, Iss , Pp 34-37 (2018)
Cytochrome P450 (CYP) comprises a superfamily of monooxygenase responsible for the metabolism of xenobiotics and approximately 75% of drugs in use today. Thus, genetic polymorphisms in CYP genes contribute to interindividual differences in hepatic me
Externí odkaz:
https://doaj.org/article/e7bd8d1b42694ea885fa679497758b8c