Zobrazeno 1 - 10
of 298
pro vyhledávání: '"Dong-Er Zhang"'
Autor:
Kivilcim Ozturk, Rebecca Panwala, Jeanna Sheen, Kyle Ford, Nathan Jayne, Andrew Portell, Dong-Er Zhang, Stephan Hutter, Torsten Haferlach, Trey Ideker, Prashant Mali, Hannah Carter
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114436- (2024)
Summary: Single-gene missense mutations remain challenging to interpret. Here, we deploy scalable functional screening by sequencing (SEUSS), a Perturb-seq method, to generate mutations at protein interfaces of RUNX1 and quantify their effect on acti
Externí odkaz:
https://doaj.org/article/7f27471aa05f450da7a0b6c86bd752a9
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103139- (2024)
Summary: Flow cytometry, single-cell RNA sequencing, and other analyses enable us to capture immune profiles of the tumor microenvironment. Here, we present a protocol to characterize the immune profile of tumor-bearing mice. We describe steps for es
Externí odkaz:
https://doaj.org/article/c350c06004044d669a13306c9c9c1f97
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Cancer immunotherapy, such as immune checkpoint blockade (ICB), has emerged as a groundbreaking approach for effective cancer treatment. Despite its considerable potential, clinical studies have indicated that the current response rate to cancer immu
Externí odkaz:
https://doaj.org/article/6f2442c7539543b095810ad7cc493d3a
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113560- (2023)
Summary: Tumor-associated myeloid cells modulate the tumor microenvironment and affect tumor progression. Type I interferon (IFN-I) has multiple effects on tumors and immune response, and ubiquitin-specific peptidase 18 (USP18) functions as a negativ
Externí odkaz:
https://doaj.org/article/95034586eaf8445683ec6b80e0a303d6
Autor:
Kei-ichiro Arimoto, Sayuri Miyauchi, Ty D. Troutman, Yue Zhang, Mengdan Liu, Samuel A. Stoner, Amanda G. Davis, Jun-Bao Fan, Yi-Jou Huang, Ming Yan, Christopher K. Glass, Dong-Er Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
The induction of immunogenic cell death (ICD) can potentiate antitumour immunity. Here the authors show that USP18, a negative regulator of IFN signaling protects cancer cells from ICD by suppressing the expression of canonical and non-canonical IFN-
Externí odkaz:
https://doaj.org/article/c55616d5f66c4fa1b5252ced6723befa
Autor:
Yajing Hao, Shuyang Zhang, Changwei Shao, Junhui Li, Guofeng Zhao, Dong-Er Zhang, Xiang-Dong Fu
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-31 (2022)
Abstract Two-dimensional high-throughput data have become increasingly common in functional genomics studies, which raises new challenges in data analysis. Here, we introduce a new statistic called Zeta, initially developed to identify global splicin
Externí odkaz:
https://doaj.org/article/672af65d14284e36a0eed3f2d359708a
Publikováno v:
Experimental Hematology & Oncology, Vol 10, Iss 1, Pp 1-12 (2021)
Abstract Background Acute myeloid leukemia (AML) with the t(8;21)(q22;q22) chromosomal translocation is among the most common subtypes of AML and produces the AML1-ETO (RUNX1-ETO, RUNX1-RUNX1T1) oncogenic fusion gene. AML1-ETO functions as an aberran
Externí odkaz:
https://doaj.org/article/97aa952932a64c95aa998f264c9dbc5e
Autor:
Akifumi Matsumoto, Tatsushi Yoshida, Takahiro Shima, Kenta Yamasaki, Kenjiro Tadagaki, Noriko Kondo, Yasumichi Kuwahara, Dong-Er Zhang, Tsukasa Okuda
Publikováno v:
BBA Advances, Vol 2, Iss , Pp 100047- (2022)
The fusion protein RUNX1-ETO is an oncogenic transcription factor generated by t(8;21) chromosome translocation, which is found in FAB-M2-type acute myeloid leukemia (AML). RUNX1-ETO is known to dysregulate the normal RUNX1 transcriptional network, w
Externí odkaz:
https://doaj.org/article/4123691a17da41c0880e4d3e26cd54c0
Autor:
Anusorn Mudla, Yanfei Jiang, Kei-ichiro Arimoto, Bingxian Xu, Adarsh Rajesh, Andy P Ryan, Wei Wang, Matthew D Daugherty, Dong-Er Zhang, Nan Hao
Publikováno v:
eLife, Vol 9 (2020)
Cells use molecular circuits to interpret and respond to extracellular cues, such as hormones and cytokines, which are often released in a temporally varying fashion. In this study, we combine microfluidics, time-lapse microscopy, and computational m
Externí odkaz:
https://doaj.org/article/e551fbd1fc3b4353826d1a986dc40a28
Autor:
Anna E. Marneth, Lacramioara Botezatu, Judith M. Hönes, Jimmy C.L. Israël, Judith Schütte, Lothar Vassen, Robert F. Lams, Saskia M. Bergevoet, Laura Groothuis, Amit Mandoli, Joost H.A. Martens, Gerwin Huls, Joop H. Jansen, Ulrich Dührsen, Tobias Berg, Tarik Möröy, Christian Wichmann, Mia-Chia Lo, Dong-Er Zhang, Bert A. van der Reijden, Cyrus Khandanpour
Publikováno v:
Haematologica, Vol 103, Iss 9 (2018)
Externí odkaz:
https://doaj.org/article/469be62eb3e14b238b05dea40665f0e6