Zobrazeno 1 - 10
of 440
pro vyhledávání: '"Dong-Er Zhang"'
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103139- (2024)
Summary: Flow cytometry, single-cell RNA sequencing, and other analyses enable us to capture immune profiles of the tumor microenvironment. Here, we present a protocol to characterize the immune profile of tumor-bearing mice. We describe steps for es
Externí odkaz:
https://doaj.org/article/c350c06004044d669a13306c9c9c1f97
Autor:
Kivilcim Ozturk, Rebecca Panwala, Jeanna Sheen, Kyle Ford, Nathan Jayne, Andrew Portell, Dong-Er Zhang, Stephan Hutter, Torsten Haferlach, Trey Ideker, Prashant Mali, Hannah Carter
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114436- (2024)
Summary: Single-gene missense mutations remain challenging to interpret. Here, we deploy scalable functional screening by sequencing (SEUSS), a Perturb-seq method, to generate mutations at protein interfaces of RUNX1 and quantify their effect on acti
Externí odkaz:
https://doaj.org/article/7f27471aa05f450da7a0b6c86bd752a9
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Cancer immunotherapy, such as immune checkpoint blockade (ICB), has emerged as a groundbreaking approach for effective cancer treatment. Despite its considerable potential, clinical studies have indicated that the current response rate to cancer immu
Externí odkaz:
https://doaj.org/article/6f2442c7539543b095810ad7cc493d3a
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113560- (2023)
Summary: Tumor-associated myeloid cells modulate the tumor microenvironment and affect tumor progression. Type I interferon (IFN-I) has multiple effects on tumors and immune response, and ubiquitin-specific peptidase 18 (USP18) functions as a negativ
Externí odkaz:
https://doaj.org/article/95034586eaf8445683ec6b80e0a303d6
Autor:
Kei-ichiro Arimoto, Sayuri Miyauchi, Ty D. Troutman, Yue Zhang, Mengdan Liu, Samuel A. Stoner, Amanda G. Davis, Jun-Bao Fan, Yi-Jou Huang, Ming Yan, Christopher K. Glass, Dong-Er Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
The induction of immunogenic cell death (ICD) can potentiate antitumour immunity. Here the authors show that USP18, a negative regulator of IFN signaling protects cancer cells from ICD by suppressing the expression of canonical and non-canonical IFN-
Externí odkaz:
https://doaj.org/article/c55616d5f66c4fa1b5252ced6723befa
Autor:
Yajing Hao, Shuyang Zhang, Changwei Shao, Junhui Li, Guofeng Zhao, Dong-Er Zhang, Xiang-Dong Fu
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-31 (2022)
Abstract Two-dimensional high-throughput data have become increasingly common in functional genomics studies, which raises new challenges in data analysis. Here, we introduce a new statistic called Zeta, initially developed to identify global splicin
Externí odkaz:
https://doaj.org/article/672af65d14284e36a0eed3f2d359708a
Publikováno v:
Experimental Hematology & Oncology, Vol 10, Iss 1, Pp 1-12 (2021)
Abstract Background Acute myeloid leukemia (AML) with the t(8;21)(q22;q22) chromosomal translocation is among the most common subtypes of AML and produces the AML1-ETO (RUNX1-ETO, RUNX1-RUNX1T1) oncogenic fusion gene. AML1-ETO functions as an aberran
Externí odkaz:
https://doaj.org/article/97aa952932a64c95aa998f264c9dbc5e
Autor:
Akifumi Matsumoto, Tatsushi Yoshida, Takahiro Shima, Kenta Yamasaki, Kenjiro Tadagaki, Noriko Kondo, Yasumichi Kuwahara, Dong-Er Zhang, Tsukasa Okuda
Publikováno v:
BBA Advances, Vol 2, Iss , Pp 100047- (2022)
The fusion protein RUNX1-ETO is an oncogenic transcription factor generated by t(8;21) chromosome translocation, which is found in FAB-M2-type acute myeloid leukemia (AML). RUNX1-ETO is known to dysregulate the normal RUNX1 transcriptional network, w
Externí odkaz:
https://doaj.org/article/4123691a17da41c0880e4d3e26cd54c0
Autor:
Anusorn Mudla, Yanfei Jiang, Kei-ichiro Arimoto, Bingxian Xu, Adarsh Rajesh, Andy P Ryan, Wei Wang, Matthew D Daugherty, Dong-Er Zhang, Nan Hao
Publikováno v:
eLife, Vol 9 (2020)
Cells use molecular circuits to interpret and respond to extracellular cues, such as hormones and cytokines, which are often released in a temporally varying fashion. In this study, we combine microfluidics, time-lapse microscopy, and computational m
Externí odkaz:
https://doaj.org/article/e551fbd1fc3b4353826d1a986dc40a28
Autor:
Dong-Er Zhang, Xiang-Dong Fu, Hu Cang, Jeremy N. Rich, Klaus-Peter Knobeloch, Balázs Győrffy, Yu Zhou, Ming Yan, Kei-ichiro Arimoto, Hua Cheng, Christoph Burkart, Leo J.Y. Kim, Dan Liu, Hui-Zhong Xu, Sayuri Miyauchi, Jun-Bao Fan
Supplementary methods and figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::319df17cbd86dd3dd97c77d84e43ad9b
https://doi.org/10.1158/2159-8290.22535659
https://doi.org/10.1158/2159-8290.22535659