Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Dong-Dong Miao"'
Autor:
Chao Zhang, Lian-Jun He, Yi-Bao Zhu, Qing-Zhu Fan, Dong-Dong Miao, Sheng-Peng Zhang, Wen-Ying Zhao, Xiao-Ping Liu
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Resistance is a major concern when administering chemotherapy to patients with non-small cell lung cancer (NSCLC). Chemosensitizer are agents that can reverse resistance to chemotherapeutic drugs, thereby enhancing the chemosensitivity of tumor cells
Externí odkaz:
https://doaj.org/article/da12046da98a45cea9dd2b4d6961fa64
Autor:
Xu Yao, Guangyu Sun, Zhang Yuncong, Dong-Dong Miao, Xiao-Yang Wang, Song Zhan, Xian-Jin Ye, Li Li, Wang Cong, Zhang Jianwei, Xiao-Dong Lin, Shan-Hui Yin, Gong-Lin Zheng
Publikováno v:
Journal of Computer Science and Technology. 35:453-467
As data volumes grow rapidly, distributed computations are widely employed in data-centers to provide cheap and efficient methods to process large-scale parallel datasets. Various computation models have been proposed to improve the abstraction of di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b842ea0f02d7e3062202f99d7a22a006
https://doi.org/10.1007/s11390-020-9702-3
https://doi.org/10.1007/s11390-020-9702-3
Autor:
Ji Zhou, Li-Zhen Yu, Ya-Li Fan, Ci-Hao Guo, Xiao-Mei Lv, Zhi-Yin Zhou, Hui-Dan Huang, Dong-Dong Miao, Sheng-Peng Zhang, Xin-Yu Li, Ping-Ping Zhao, Xiao-Ping Liu, Wei-Hua Hu, Chao Zhang
Publikováno v:
European Journal of Medicinal Chemistry. 245:114860
In order to take advantage of both immunotherapeutic and metabolic antitumor agents, novel dual indoleamine 2,3- dioxygenase 1 (IDO1) and thioredoxin reductase 1 (TrxR1) inhibitors were designed. Thioredoxin reductase 1 (TrxR1) is a main ROS modulato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acd5169bbb7d72a3b031755f8dceae58
https://doi.org/10.1016/j.ejmech.2022.114860
https://doi.org/10.1016/j.ejmech.2022.114860
Autor:
Sheng-Peng Zhang, Yi-Bao Zhu, Chao Zhang, Lian-Jun He, Xiao-Ping Liu, Dong-Dong Miao, Ji Zhou, Qing-Zhu Fan
Publikováno v:
Bioorganic chemistry. 105
Targeting the Trp-Kyn pathway is an attractive approach for cancer immunotherapy. Thioredoxin reductase (TrxR) enzymes are reactive oxygen species (ROS) modulators that are involved in the tumor cell growth and survival processes. The 4-phenylimidazo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23265a8ff2ea18a277395b57133c6340
https://pubmed.ncbi.nlm.nih.gov/33113415
https://pubmed.ncbi.nlm.nih.gov/33113415
Autor:
Dong-Dong Miao, Yi-Bao Zhu, Sheng-Peng Zhang, Qing-Zhu Fan, Chao Zhang, Xiao-Ping Liu, Lian-Jun He
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(4)
With the aim of discovering novel cyclin-dependent kinase 8 (CDK8) inhibitors, a combined similarity search and molecular docking approach was employed, which led to 32 hits. Biological tests led to the discovery of several novel submicromolar inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0f4d3cdd1cbcb27f51d2f71a09ebf0
https://pubmed.ncbi.nlm.nih.gov/30630717
https://pubmed.ncbi.nlm.nih.gov/30630717
Autor:
Yun‑Yu Chen, Yuan‑Wei Jia, Ding‑Feng Liu, Yi‑Bao Zhu, Chao Zhang, Dong‑Dong Miao, Xiao‑Ping Liu, Sheng‑Peng Zhang, Jie Shen, Hai‑Zhu Ye, Lian‑Jun He
Publikováno v:
Molecular Medicine Reports
Multidrug resistance (MDR) is a major concern when using chemotherapy for the treatment of patients with colorectal cancer. MDR modulators are agents that can reverse MDR and, thus, enhance the chemosensitivity of tumor cells. The development of MDR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a77b464379574ec62cd09f0b7c8e8f0f
https://doi.org/10.3892/mmr.2018.9589
https://doi.org/10.3892/mmr.2018.9589