Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Dong-Dong Luo"'
Autor:
Zhi-Kun Guo, Ying-Zhi Zhang, Yu-Hang Zhang, Dong-Dong Luo, Sheng-Biao Wan, Xianjun Qu, shuxiang cui
Background and Purpose: Dihydropyrimidine dehydrogenase (DPD) is a major determinant of 5-FU resistance in cancers. DPD catalyzes 5-FU into FBAL (α-fluoro-β-alanine) to lower intracellular 5-FU level. We aimed to investigate mechanism and clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1e59028a180bc657a60957aff5667db
https://doi.org/10.22541/au.164375702.24504582/v1
https://doi.org/10.22541/au.164375702.24504582/v1
Autor:
Shengbiao Wan, Zirong Deng, Shu-Xiang Cui, Yuhang Zhang, Xian-Jun Qu, Zhikun Guo, Xiaochun Liu, Yingzhi Zhang, Li-Juan Wu, Dong-Dong Luo, Xuecui Zhao
Publikováno v:
European journal of medicinal chemistry. 227
Sphingosine-1-phosphate receptor 2 (S1PR2) has been identified as a brand-new GPCR target for designing antagonists to reverse 5-FU resistance. We herein report the structural optimization and structure-activity relationship of JTE-013 derivatives as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106fe3833b488e54c7aebe1820f3304d
https://pubmed.ncbi.nlm.nih.gov/34688013
https://pubmed.ncbi.nlm.nih.gov/34688013
Autor:
Shuang Yang, Xiaochen Tian, Shu-Xiang Cui, Wen-Yu Wang, Shengbiao Wan, Xian-Jun Qu, Shuai Liu, Zhikun Guo, Yan Lv, Gaitian Han, Xiaochun Liu, Dong-Dong Luo, Yuhang Zhang
Publikováno v:
European journal of medicinal chemistry. 225
5-Fluorouracil (5-FU) and its prodrugs are the essential clinical drugs for colorectal cancer (CRC) treatment. However, the drug resistance of 5-FU has caused high mortality of CRC patients. Thus, it is urgent to develop reversal agents of 5-FU resis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ea5d87115fce97ea6b27f2a4334e3f
https://pubmed.ncbi.nlm.nih.gov/34411894
https://pubmed.ncbi.nlm.nih.gov/34411894
Autor:
Wan-Zhou Zhao, Tangrong Liu, Yuchao Gu, Xian-Jun Qu, Jia-Yu Yang, Wengong Yu, Kai Peng, Dong-Dong Luo, Yujiao Yi, Shan Liu, Shengbiao Wan
Publikováno v:
European Journal of Medicinal Chemistry. 178:365-379
The biological function of the natural ent-kaurene diterpenoid isolated from genus Isodon, oridonin, has been intensively studied. However, its mechanism studies and clinical applications were hampered by its moderate biological activities. In order
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492a75ac4400ea32544648858d73d18b
https://doi.org/10.1016/j.ejmech.2019.06.006
https://doi.org/10.1016/j.ejmech.2019.06.006
Autor:
Yu-Hang, Zhang, Wen-Na, Shi, Shu-Hua, Wu, Rong-Rong, Miao, Shi-Yue, Sun, Dong-Dong, Luo, Sheng-Biao, Wan, Zhi-Kun, Guo, Wen-Yu, Wang, Xin-Feng, Yu, Shu-Xiang, Cui, Xian-Jun, Qu
Publikováno v:
Oncogene. 39(29)
Aberrant sphingolipid metabolism has been implicated in chemoresistance, but the underlying mechanisms are still poorly understood. Herein we revealed a previously unrecognized mechanism of 5-fluorouracil (5-FU) resistance contributed by high SphK2-u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a30d0ab64b0d0716e6324fd9794ec8ef
https://pubmed.ncbi.nlm.nih.gov/32546724
https://pubmed.ncbi.nlm.nih.gov/32546724
Autor:
Kai Peng, Dong-Dong Luo, Jia-Yu Yang, Yu Tang, Wan-Zhou Zhao, Pawinee Piyachaturawat, Ao Lei, Shengbiao Wan, Witchuda Saengsawang
Publikováno v:
RSC Advances. 8:29548-29554
A simple and efficient protocol was developed for the syntheses of oridonin analogues, i.e. 6,20-epoxy ent-kaurane diterpenoid analogues from oridonin via diethylaminosulfur trifluoride (DAST) promoted rearrangement, most of which exhibited superior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f97ad10fd274a1909a4ceddef14e1b96
https://doi.org/10.1039/c8ra05728a
https://doi.org/10.1039/c8ra05728a
Publikováno v:
Pharmacological Research. 159:104834
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22dab30c62a085352d841c7fd5ed7180
https://doi.org/10.1016/j.phrs.2020.104834
https://doi.org/10.1016/j.phrs.2020.104834
Publikováno v:
Pharmacological Research. 155:104717
In this study, S1PR2 was reckoned as a brand-new GPCR target for designing inhibitors to reverse 5-FU resistance. Herein a series of pyrrolidine pyrazoles as the S1PR2 inhibitors were designed, synthesized and evaluated for their activities of anti-F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::929584364d3d7535616c22e6c7ccd0c3
https://doi.org/10.1016/j.phrs.2020.104717
https://doi.org/10.1016/j.phrs.2020.104717
Autor:
Dong-Dong, Luo, Kai, Peng, Jia-Yu, Yang, Pawinee, Piyachaturawat, Witchuda, Saengsawang, Lei, Ao, Wan-Zhou, Zhao, Yu, Tang, Sheng-Biao, Wan
Publikováno v:
RSC advances. 8(52)
A simple and efficient protocol was developed for the syntheses of oridonin analogues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8615fdc764ebd4aee307d390cb51cbe7
https://pubmed.ncbi.nlm.nih.gov/35547324
https://pubmed.ncbi.nlm.nih.gov/35547324
Publikováno v:
Applied Mechanics and Materials. 618:588-592
For hourglass worm three-dimensional modeling, in the Process that Using MATLAB software Calculating the Generated * ·ibl files and leading-in Pro /E software comply hourglass worm three-dimensional modeling, MATLAB Calculate Generated Worm spiral c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3413b3adf751c1c63359f3a00ad1149
https://doi.org/10.4028/www.scientific.net/amm.618.588
https://doi.org/10.4028/www.scientific.net/amm.618.588