Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Dong Zhe Jin"'
Autor:
Srikar Rao, Jeong A. Lee, Dae Hong Shin, Sang Kook Lee, Hea Ok Kim, Moon Woo Chun, Heng T. Duong, Hyung Ryong Moon, Prashantha Gunaga, Ji Young Jung, Zhan-Guo Gao, Dong Zhe Jin, Kenneth A. Jacobson, Lak Shin Jeong, Hyuk Woo Lee
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:4718-4730
A large series of N6-substituted-4′-thioadenosines were synthesized starting from d -gulonic-γ-lactone, and structure–activity relationships were studied at the human A3 and other subtypes of adenosine receptors (ARs). 2-Chloro-substituted and 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b12033bab88b5474ee6fdbcada1d9e
https://doi.org/10.1016/j.bmc.2006.03.030
https://doi.org/10.1016/j.bmc.2006.03.030
Autor:
Dong Zhe Jin, Hea Ok Kim, Prashantha Gunaga, Moon Woo Chun, Hyung Ryong Moon, Dae-Kee Kim, Sung Hee Kwon, Lak Shin Jeong
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:1101-1109
The present work describes the asymmetric synthesis of D- and L-apio-2',3'-dideoxynucleoside analogues, 4 and 5 with 2'-hydroxyl group via a common intermediate 9, starting from D-galactose. Stereoselective dihydroxylation and deoxygenation through r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dcab43eba84bcdc633713a28a0b5544
https://doi.org/10.1016/j.bmc.2003.12.002
https://doi.org/10.1016/j.bmc.2003.12.002
Publikováno v:
Yao xue xue bao = Acta pharmaceutica Sinica. 44(7)
Taking 3'-Me-Ado (3'-methyladenosine) and Cladribine as the leading compounds, seventeen 3'-C-methyl-furanonucleosides were designed and synthesized. All the structures were confirmed by 1H NMR and MS. The target compounds were tested in vitro agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1bda1825378831ff399c58b1e30a52ea
https://pubmed.ncbi.nlm.nih.gov/19806914
https://pubmed.ncbi.nlm.nih.gov/19806914
Autor:
Dae Hong Shin, Kenneth A. Jacobson, Lak Shin Jeong, Dong Zhe Jin, Jeong A. Lee, Hea Ok Kim, Moon Woo Chun, Hyung Ryong Moon, Heng T. Duong, Changrui Lu, Sang Kook Lee, Hyuk Woo Lee, Prashantha Gunaga, Zhan-Guo Gao
Publikováno v:
Journal of medicinal chemistry. 49(1)
We have established structure-activity relationships of novel 4'-thionucleoside analogues as the A(3) adenosine receptor (AR) agonists. Binding affinity, selectivity toward other AR subtypes, and efficacy in inhibition of adenylate cyclase were studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5f4b076c169b51ed9e2a41513d97a7
https://pubmed.ncbi.nlm.nih.gov/16392812
https://pubmed.ncbi.nlm.nih.gov/16392812
Autor:
Yong-Chul Kim, Prashantha Gunaga, Dae Hong Shin, Neli Melman, Hyung Ryong Moon, Zhan-Guo Gao, Hea Ok Kim, Moon Woo Chun, Dong Zhe Jin, Kenneth A. Jacobson, Lak Shin Jeong
Publikováno v:
Journal of medicinal chemistry. 46(18)
4'-Thio analogues 3-5 of Cl-IB-MECA (2) (K(i) = 1.0 +/- 0.2 nM at the human A(3) adenosine receptor) were synthesized from d-gulono-gamma-lactone via 4-thioribosyl acetate 14 as the key intermediate. All synthesized 4'-thionucleosides exhibited highe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5f9bf167df13b43176ecc9242a4ff2
https://pubmed.ncbi.nlm.nih.gov/12930138
https://pubmed.ncbi.nlm.nih.gov/12930138