Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Dong Gui Hu"'
Autor:
Julie-Ann Hulin, Sara Tommasi, David Elliot, Dong Gui Hu, Benjamin C. Lewis, Arduino A. Mangoni
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Dimethylarginine dimethylaminohydrolase 1 (DDAH1) is responsible for metabolism of an endogenous inhibitor of nitric oxide synthase (NOS), asymmetric dimethylarginine (ADMA), which plays a key role in modulating angiogenesis. In addition to
Externí odkaz:
https://doaj.org/article/9458664a66d5495589105adce62f38ad
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4314 (2021)
Breast cancer MCF-7 cell-line-derived mammospheres were shown to be enriched in cells with a CD44+/CD24– surface profile, consistent with breast cancer stem cells (BCSC). These BCSC were previously reported to express key sphingolipid signaling eff
Externí odkaz:
https://doaj.org/article/26c082a770f8408ba20e0f0562fa45b8
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 1, p 40 (2016)
Nearly 20 different transcripts of the human androgen receptor (AR) are reported with two currently listed as Refseq isoforms in the NCBI database. Isoform 1 encodes wild-type AR (type 1 AR) and isoform 2 encodes the variant AR45 (type 2 AR). Both va
Externí odkaz:
https://doaj.org/article/820c41cabafc446fb95dbb525bdfa553
Publikováno v:
Drug Metabolism Reviews. 54:120-140
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::499adfb85ac7b8ceec63a90c7af09e81
https://doi.org/10.1080/03602532.2022.2048846
https://doi.org/10.1080/03602532.2022.2048846
Autor:
Dong Gui Hu, Shashikanth Marri, Julie-Ann Hulin, Ross A. McKinnon, Peter I. Mackenzie, Robyn Meech
Publikováno v:
Cancers; Volume 14; Issue 22; Pages: 5708
The human UDP-glycosyltransferase (UGTs) superfamily has a critical role in the metabolism of anticancer drugs and numerous pro/anti-cancer molecules (e.g., steroids, lipids, fatty acids, bile acids and carcinogens). Recent studies have shown wide an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838e2e86e1de9cd4c52660cbce9a8f5f
Publikováno v:
Molecular Pharmacology. 99:488-503
The human UDP-glycosyltransferase (UGT) gene superfamily generates 22 canonical transcripts coding for functional enzymes and also produces nearly 150 variant UGT transcripts through alternative splicing and intergenic splicing. In the present study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2b755833de388f58ce03d6bc73476b3
https://doi.org/10.1124/molpharm.120.000225
https://doi.org/10.1124/molpharm.120.000225
Autor:
Dong Gui Hu, Ross A. McKinnon, Peter I. Mackenzie, Shashikanth Marri, Robyn Meech, Julie-Ann Hulin
Publikováno v:
Cancers, Vol 13, Iss 4491, p 4491 (2021)
Cancers
Volume 13
Issue 17
Cancers
Volume 13
Issue 17
The human UDP-glycosyltransferase (UGTs) superfamily has 22 functional enzymes that play a critical role in the metabolism of small lipophilic compounds, including carcinogens, drugs, steroids, lipids, fatty acids, and bile acids. The expression prof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa8ed3ec40de86e0edf7d65f8df5114e
https://www.mdpi.com/2072-6694/13/17/4491
https://www.mdpi.com/2072-6694/13/17/4491
Autor:
Dong Gui Hu, Siti Nurul Mubarokah, Robyn Meech, Peter I. Mackenzie, Pramod C. Nair, Ross A. McKinnon, Andrew Rowland, Alex Z. Haines
Publikováno v:
Physiological Reviews. 99:1153-1222
UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad range of exogenous chemicals and by-products of endogenous metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6fed9c56ca78819d8b2ddf711a20b54
https://doi.org/10.1152/physrev.00058.2017
https://doi.org/10.1152/physrev.00058.2017
Publikováno v:
Molecular pharmacology. 99(6)
The human UDP-glycosyltransferase (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc12cfb3bc3650bfd4a77875311ff4b4
https://pubmed.ncbi.nlm.nih.gov/33824186
https://pubmed.ncbi.nlm.nih.gov/33824186
The Expression Profiles of ADME Genes in Human Cancers and Their Associations with Clinical Outcomes
Publikováno v:
Cancers
Volume 12
Issue 11
Cancers, Vol 12, Iss 3369, p 3369 (2020)
Volume 12
Issue 11
Cancers, Vol 12, Iss 3369, p 3369 (2020)
ADME genes are a group of genes that are involved in drug absorption, distribution, metabolism, and excretion (ADME). The expression profiles of ADME genes within tumours is proposed to impact on cancer patient survival
however, this has not bee
however, this has not bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45da8e46386fe2546316df0402252b5