Zobrazeno 1 - 10
of 437
pro vyhledávání: '"Dong‐Zhi Wei"'
Autor:
Qidi Guo, Jiaqi Xu, Jiacun Li, Shuyan Tang, Yuhui Cheng, Bei Gao, Liang-Bin Xiong, Jie Xiong, Feng-Qing Wang, Dong-Zhi Wei
Publikováno v:
Synthetic and Systems Biotechnology, Vol 9, Iss 4, Pp 834-841 (2024)
Coproporphyrin III (CP III), a natural porphyrin derivative, has extensive applications in the biomedical and material industries. S. cerevisiae has previously been engineered to highly accumulate the CP III precursor 5-aminolevulinic acid (ALA) thro
Externí odkaz:
https://doaj.org/article/f81cc809dbaa49ad8d4e297a1842bad1
Autor:
Yun-Qiu Zhao, Yong-Jun Liu, Lu Song, Dingyan Yu, Kun Liu, Ke Liu, Bei Gao, Xin-Yi Tao, Liang-Bin Xiong, Feng-Qing Wang, Dong-Zhi Wei
Publikováno v:
Biotechnology for Biofuels and Bioproducts, Vol 16, Iss 1, Pp 1-17 (2023)
Abstract Background Harnessing engineered Mycolicibacteria to convert cheap phytosterols into valuable steroid synthons is a basic way in the industry for the production of steroid hormones. Thus, C-19 and C-22 steroids are the two main types of comm
Externí odkaz:
https://doaj.org/article/9fa6d9b7e4744e4c8415c0c34c067841
Publikováno v:
Biotechnology for Biofuels and Bioproducts, Vol 16, Iss 1, Pp 1-15 (2023)
Abstract Background The conversion of phytosterols to steroid synthons by engineered Mycolicibacteria comprises one of the core steps in the commercial production of steroid hormones. This is a complex oxidative catabolic process, and taking the prod
Externí odkaz:
https://doaj.org/article/236243e39c8046fdb864c2ce835c2371
Autor:
Meng-Meng Du, Ge-Ge Zhang, Zhan-Tao Zhu, Yun-Qiu Zhao, Bei Gao, Xin-Yi Tao, Feng-Qing Wang, Dong-Zhi Wei
Publikováno v:
Biotechnology for Biofuels and Bioproducts, Vol 16, Iss 1, Pp 1-15 (2023)
Abstract Background Polycyclic triterpenoids (PTs) are common in plants, and have attracted considerable interest due to their remarkable biological activities. Currently, engineering the ergosterol synthesis pathway in Saccharomyces cerevisiae is a
Externí odkaz:
https://doaj.org/article/041905670f4f4415ac2188412710f393
Autor:
Ke Liu, Gui-Hong Lin, Kun Liu, Yong-Jun Liu, Xin-Yi Tao, Bei Gao, Ming Zhao, Dong-Zhi Wei, Feng-Qing Wang
Publikováno v:
Synthetic and Systems Biotechnology, Vol 7, Iss 3, Pp 1002-1011 (2022)
Genomic integration of genes and pathway-sized DNA cassettes is often an indispensable way to construct robust and productive microbial cell factories. For some uncommon microbial hosts, such as Mycolicibacterium and Mycobacterium species, however, i
Externí odkaz:
https://doaj.org/article/f163570f81b741788043595dadd0bd52
Autor:
Bing-Yao Sun, Hua-Lu Sui, Zi-Wei Liu, Xin-Yi Tao, Bei Gao, Ming Zhao, Yu-Shu Ma, Jian Zhao, Min Liu, Feng-Qing Wang, Dong-Zhi Wei
Publikováno v:
Bioresources and Bioprocessing, Vol 9, Iss 1, Pp 1-16 (2022)
Abstract Indirubin is a bisindole compound for the treatment of chronic myelocytic leukemia. Here, we presented a structure-guided method to improve the activity of a flavin-containing monooxygenase (bFMO) for the efficient production of indirubin in
Externí odkaz:
https://doaj.org/article/992e921123c74f94bbce295658375330
Autor:
Yun-Qiu Zhao, Yong-Jun Liu, Wei-Ting Ji, Kun Liu, Bei Gao, Xin-Yi Tao, Ming Zhao, Feng-Qing Wang, Dong-Zhi Wei
Publikováno v:
Microbial Cell Factories, Vol 21, Iss 1, Pp 1-13 (2022)
Abstract Background 7β-hydroxylated steroids (7β-OHSt) possess significant activities in anti-inflammatory and neuroprotection, and some of them have been widely used in clinics. However, the production of 7β-OHSt is still a challenge due to the l
Externí odkaz:
https://doaj.org/article/0cdbee409d4b46c1bb161329ae4fb251
Autor:
Liang‐Bin Xiong, Zhi‐Yong Xie, Jie Ke, Li Wang, Bei Gao, Xin‐Yi Tao, Ming Zhao, Ya‐Ling Shen, Dong‐Zhi Wei, Feng‐Qing Wang
Publikováno v:
Food Bioengineering, Vol 1, Iss 1, Pp 26-36 (2022)
Abstract Ergothioneine (EGT) represents valuable protective functions for humans, but EGT from the diet cannot meet daily requirements. Although the heterologous synthesis of EGT had been achieved, it is still a challenge to obtain stable and high‐
Externí odkaz:
https://doaj.org/article/473f1cf389324fb0886de21919274e57
Autor:
Liang-Bin Xiong, Hao-Hao Liu, Lu Song, Miao-Miao Dong, Jie Ke, Yong-Jun Liu, Ke Liu, Ming Zhao, Feng-Qing Wang, Dong-Zhi Wei
Publikováno v:
Synthetic and Systems Biotechnology, Vol 7, Iss 1, Pp 453-459 (2022)
Biotransformation of soybean phytosterols into 9α-hydroxy-4-androstene-3,17-dione (9-OHAD) by mycobacteria is the core step in the synthesis of adrenocortical hormone. However, the low permeability of the dense cell envelope largely inhibits the ove
Externí odkaz:
https://doaj.org/article/910c885832ea4ddeb5c33a8fc8c4549d
Publikováno v:
BMC Biotechnology, Vol 20, Iss 1, Pp 1-10 (2020)
Abstract Background Esterases are widely distributed in nature and have important applications in medical, industrial and physiological. Recently, the increased demand for flavor esters has prompted the search of catalysts like lipases and esterases.
Externí odkaz:
https://doaj.org/article/107b1227549d440c8cd79d9e3d948a8d