Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Donato Pocar"'
Autor:
Guido Pontremoli, Sara Pellegrino, Mauro Cimino, Ezio Bombardelli, Gabriele Fontana, Walter Balduini, Antonella Riva, Maria Luisa Gelmi, Donato Pocar, Silvia Carloni
Publikováno v:
Journal of Medicinal Chemistry. 50:2245-2248
New 3-O-glycosyl-3-demethylthiocolchicines containing natural and unnatural sugar moieties were prepared and tested on gamma-aminobutyric acid (GABA) and strychnine-sensitive glycine receptors present in rat brain and spinal cord. Two different synth
Publikováno v:
Synthesis. 2006:2693-2696
Various β-hydroxy-substituted amidines were obtained starting from methyl serinates, aldehydes or ketones, and tosyl azide. These were converted via Mitsunobu intramolecular cyclization into enantiomerically pure methyl 2-alkyl-l-tosyl-4,5-dihydro-1
Publikováno v:
Tetrahedron: Asymmetry. 17:1430-1436
Novel 1-aminocyclopentane-1,2,4-tricarboxylic acids 11 and 14 containing the glutamic acid skeleton were prepared as two diastereomers characterized by having the carbonyl groups in positions two and four cis to each other and trans with respect to t
Autor:
Giacomo Carenzi, Donato Pocar, Arturo Battaglia, Andrea Guerrini, Ezio Bombardelli, Maria Luisa Gelmi, Gabriele Fontana, Eleonora Baldelli
Publikováno v:
Tetrahedron. 61:7727-7745
The base induced deprotonation of H-14 of 7-triethylsilyl- (7-TES-) and 7-tert-butoxycarbonyl- (7-BOC-) protected 13-oxo-baccatins gave the corresponding enolates, which were selectively aminated with electrophilic nitrogen donors, such as azodicarbo
Publikováno v:
Tetrahedron. 61:5778-5781
A single step synthesis of 2,3-dialkyl-6-nitro-quinazolin-4(3H)-imines and 3,5-dialkyl-9-nitro-imidazo-[1,2-c]-quinazolin-2(3H)-ones from simple carbonyl compounds, primary amines or amino acid methyl esters and 2-azido-5-nitro-benzonitrile was devel
Autor:
A. Guerrini, Arturo Battaglia, Andrea Gambini, Giacomo Carenzi, Ezio Bombardelli, Donato Pocar, Maria Luisa Gelmi, Gabriele Fontana, Eleonora Baldelli
Publikováno v:
The Journal of Organic Chemistry. 68:9773-9779
14beta-Hydroxybaccatin III, a compound with limited availability by natural sources, is the starting material for the synthesis of the second-generation anticancer taxoid ortataxel. The 7-tert-butoxycarbonyl (1a) and 7-triethylsilyl (1b) derivatives
Publikováno v:
Tetrahedron: Asymmetry. 12:2663-2669
A diastereoselective and enantioselective synthesis of (Z)-1-benzoylamino-2-tritylsulfanylcyclopropanecarboxylic acid derivatives 8a,b and 9a,b was achieved starting from (−)- or (+)-menthyl 2-benzoylamino-3-tritylsulfanylacrylates 3a,b. Compounds
Autor:
Francesca Clerici, Mario Brufani, Vincenzo Perlini, Donato Pocar, Antonella Loche, Maddalena Guido
Publikováno v:
Journal of Medicinal Chemistry. 44:931-936
Recently a series of 2-amino-5-sulfanyl-1,3,4-thiadiazole derivatives bearing different substituents were synthesized and screened pharmacologically in order to evaluate their central nervous system activity. The purpose of this study was to evaluate
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1723-1728
Pyrolysis of 4-aryl-5-morpholino-4,5-dihydrotriazoles 3 affords two products: pyrano[4,3-b]pyrrol-4(1H)-ones 4 and arylacetamidines 5. The reaction mechanism of this transformation is discussed and reaction conditions optimized to enhance the formati
Publikováno v:
Tetrahedron. 56:9991-9997
The 2-amidinylindole-3-carbaldehydes 1 are the key starting materials for the preparation of three classes of carbolines 2 , 6 and 7 in which the pyridine ring is characterised by a different substitution patterns. The carbolines 2 which are function