Therapeutic inhibition of USP9x-mediated Notch signaling in triple-negative breast cancer.

Autor: Jaiswal A; Department of Medical Biophysics, University of Toronto, Toronto, ON M1C 1A4, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4, Canada., Murakami K; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4, Canada., Elia A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4, Canada., Shibahara Y; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M1C 1A4, Canada.; Laboratory Medicine Program, University Health Network, Toronto, ON M5G 2C4, Canada., Done SJ; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M1C 1A4, Canada.; Laboratory Medicine Program, University Health Network, Toronto, ON M5G 2C4, Canada., Wood SA; Griffith Institute for Drug Discovery, Griffith University, Brisbane QLD 4111, Australia., Donato NJ; Department of Internal Medicine/Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI 48109.; School of Medicine and Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109., Ohashi PS; Department of Medical Biophysics, University of Toronto, Toronto, ON M1C 1A4, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4, Canada.; Department of Immunology, University of Toronto, Toronto, ON M1C 1A4, Canada., Reedijk M; Department of Medical Biophysics, University of Toronto, Toronto, ON M1C 1A4, Canada; michael.reedijk@uhn.ca.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4, Canada.; Department of Surgical Oncology, University Health Network, Toronto, ON M5G 2C4, Canada.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Sep 21; Vol. 118 (38).

USP14 inhibition promotes DNA damage repair and represses ovarian granulosa cell senescence in premature ovarian insufficiency.

Autor: Ma, Lin-Zi¹ (AUTHOR), Wang, Ao¹ (AUTHOR), Lai, Yun-Hui¹ (AUTHOR), Zhang, Jun¹ (AUTHOR), Zhang, Xiao-Fei¹ (AUTHOR), Chen, Shi-Ling¹ (AUTHOR) chensl_92@vip.163.com, Zhou, Xing-Yu^1,2 (AUTHOR) zhouxy315@163.com

Publikováno v: Journal of Translational Medicine. 9/11/2024, Vol. 22 Issue 1, p1-19. 19p.

Longitudinal multiomics analysis of aggressive pituitary neuroendocrine tumors: comparing primary and recurrent tumors from the same patient, reveals genomic stability and heterogeneous transcriptomic profiles with alterations in metabolic pathways.

Autor: Taniguchi-Ponciano, Keiko¹ (AUTHOR), Hinojosa-Alvarez, Silvia² (AUTHOR), Hernandez-Perez, Jesus² (AUTHOR), Chavez-Santoscoy, Rocio A.² (AUTHOR), Remba-Shapiro, Ilan¹ (AUTHOR), Guinto, Gerardo³ (AUTHOR), Magallon-Gayon, Erika² (AUTHOR), Telles-Ramirez, Benjamin² (AUTHOR), de Leon-Conconi, Rodrigo Ponce² (AUTHOR), Vela-Patiño, Sandra¹ (AUTHOR), Andonegui-Elguera, Sergio¹ (AUTHOR), Cano-Zaragoza, Amayrani¹ (AUTHOR), Martinez-Mendoza, Florencia¹ (AUTHOR), Kerbel, Jacobo¹ (AUTHOR), Loza-Mejia, Marco⁴ (AUTHOR), Rodrigo-Salazar, Juan⁴ (AUTHOR), Mendez-Perez, Alonso⁴ (AUTHOR), Aguilar-Flores, Cristina⁵ (AUTHOR), Chavez-Gonzalez, Antonieta⁶ (AUTHOR), Ortiz-Reyes, Elenka⁶ (AUTHOR)

Publikováno v: Acta Neuropathologica Communications. 8/31/2024, Vol. 12 Issue 1, p1-20. 20p.

Ubiquitination and deubiquitination in cancer: from mechanisms to novel therapeutic approaches.

Autor: Liu, Fangfang^1,2 (AUTHOR), Chen, Jingyu³ (AUTHOR), Li, Kai⁴ (AUTHOR), Li, Haochen⁴ (AUTHOR), Zhu, Yiyi⁴ (AUTHOR), Zhai, Yubo⁵ (AUTHOR), Lu, Bingbing⁵ (AUTHOR), Fan, Yanle² (AUTHOR), Liu, Ziyue⁵ (AUTHOR), Chen, Xiaojie⁶ (AUTHOR), Jia, Xuechao⁷ (AUTHOR) xcjia@hci-cn.org, Dong, Zigang^1,2,5 (AUTHOR) dongzg@zzu.edu.cn, Liu, Kangdong^1,5 (AUTHOR) kdliu@zzu.edu.cn

Publikováno v: Molecular Cancer. 7/25/2024, Vol. 23 Issue 1, p1-50. 50p.

Usp9x Promotes Survival in Human Pancreatic Cancer and Its Inhibition Suppresses Pancreatic Ductal Adenocarcinoma In Vivo Tumor Growth.

Autor: Pal A; Department of Internal Medicine/Division of Hematology/Oncology, University of Michigan School of Medicine and Comprehensive Cancer Center., Dziubinski M; Department of Surgery, University of Michigan School of Medicine., Di Magliano MP; Department of Surgery, University of Michigan School of Medicine., Simeone DM; Department of Surgery, University of Michigan School of Medicine., Owens S; Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI., Thomas D; Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI., Peterson L; Department of Internal Medicine/Division of Hematology/Oncology, University of Michigan School of Medicine and Comprehensive Cancer Center., Potu H; Department of Internal Medicine/Division of Hematology/Oncology, University of Michigan School of Medicine and Comprehensive Cancer Center., Talpaz M; Department of Internal Medicine/Division of Hematology/Oncology, University of Michigan School of Medicine and Comprehensive Cancer Center., Donato NJ; Department of Internal Medicine/Division of Hematology/Oncology, University of Michigan School of Medicine and Comprehensive Cancer Center. Electronic address: nick.donato@nih.gov.

Publikováno v: Neoplasia (New York, N.Y.) [Neoplasia] 2018 Feb; Vol. 20 (2), pp. 152-164. Date of Electronic Publication: 2017 Dec 14.