Ligand-Gated Ion Channels as Targets for Treatment and Management of Cancers

Autor: Rohan Rao, Sanjit Shah, Debanjan Bhattacharya, Donatien Kamdem Toukam, Román Cáceres, Daniel A. Pomeranz Krummel, Soma Sengupta

Publikováno v: Frontiers in Physiology, Vol 13 (2022)

Ligand-gated ion channels are an ionotropic receptor subtype characterized by the binding of an extracellular ligand, followed by the transient passage of ions through a transmembrane pore. Ligand-gated ion channels are commonly subcategorized into t

Externí odkaz: https://doaj.org/article/4440816b4f0f485581f61b6b855aa0ba

EXTH-99. SYSTEMIC AND BRAIN PHARMACOKINETICS OF A GABAA RECEPTOR AGONIST, AMLAL-101, AS AN INVESTIGATIONAL THERAPEUTIC FOR THE TREATMENT OF PRIMARY AND METASTATIC BRAIN CANCERS

Autor: Aniruddha Karve, Taukir Ahmed, Janki Desai, Debanjan Bhattacharya, Donatien Kamdem Toukam, Sidharth Gadgil, Merissa Pemberton, David Plas, Gary Gudelsky, Larry Sallans, James Cook, Pankaj Desai, Daniel Pomeranz Krummel, Soma Sengupta

Publikováno v: Neuro-Oncology. 24:vii232-vii233

PURPOSE AMLAL-101 is a novel agent which preferentially targets α3, α5 subtypes of ɣ-amino butyric acid receptors and shows anti-tumor activity against disparate cancer types. AMLAL-101 is being advanced as an ‘add-on’ to potentiate treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c1c62ccde39f02127ea14bb46c4bf2c
https://doi.org/10.1093/neuonc/noac209.897

RBIO-02. ACTIVATION OF GABAA RECEPTORS WITH A NON-TOXIC, BRAIN PENETRANT SMALL MOLECULE SENSITIZES LUNG ADENOCARCINOMA PRIMARY AND BRAIN METASTATIC TUMOR CELLS TO RADIATION VIA AUTOPHAGY INDUCTION

Autor: Debanjan Bhattacharya, Riccardo Barille, Donatien Kamdem Toukam, Vaibhavkumar Gawali, Laura Kallay, Taukir Ahmed, James Cook, Aniruddha Karve, Pankaj Desai, Mario Medvedovic, Daniel Pomeranz Krummel, Soma Sengupta

Publikováno v: Neuro-Oncology. 24:vii247-vii247

Most advanced-stage non-small cell lung cancer (NSCLC) patients have brain metastases that render a dismal prognosis. Treatment of metastatic brain lesions from NSCLC and other tumor types include radiation as part of a multimodal treatment regimen.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3539761b656ec7408395f797a0c1caf
https://doi.org/10.1093/neuonc/noac209.954

Abstract A52: Vaccine cells derived from cancer stem cells expressing interleukin-15 and its receptor inhibit tumor growth

Autor: Jason C. Steel, Donatien Kamdem Toukam, Christian Carwell, Ihab Eldessouki, John C. Morris

Publikováno v: Cancer Immunology Research. 6:A52-A52

Background: Interleukin-15 (IL-15) is a powerful activator and inducer of NK cells and cytolytic CD8+ T cells. IL-15 also activates and expands CD8+ memory T cells without stimulating immunosuppressive CD4+CD25+ T regulatory cells. As such, IL-15 may

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90d6ae4c3d47c9d694b26bc3ea61d78d
https://doi.org/10.1158/2326-6074.tumimm17-a52

GABA(A) Receptor Activation Drives GABARAP–Nix Mediated Autophagy to Radiation-Sensitize Primary and Brain-Metastatic Lung Adenocarcinoma Tumors.

Autor: Bhattacharya, Debanjan¹ (AUTHOR) bhattadj@ucmail.uc.edu, Barrile, Riccardo² (AUTHOR) barrilro@ucmail.uc.edu, Toukam, Donatien Kamdem¹ (AUTHOR) kamdemde@ucmail.uc.edu, Gawali, Vaibhavkumar S.¹ (AUTHOR) vaibhav.gawali@hotmail.com, Kallay, Laura¹ (AUTHOR) kallaylm@ucmail.uc.edu, Ahmed, Taukir³ (AUTHOR) tahmed@uwm.edu, Brown, Hawley⁴ (AUTHOR) hawley.brown@tufts.edu, Rezvanian, Sepideh³ (AUTHOR) rezvani3@uwm.edu, Karve, Aniruddha⁵ (AUTHOR) karveas@ucmail.uc.edu, Desai, Pankaj B.⁵ (AUTHOR) desaipb@ucmail.uc.edu, Medvedovic, Mario⁶ (AUTHOR) medvedm@ucmail.uc.edu, Wang, Kyle⁷ (AUTHOR) wang2kl@ucmail.uc.edu, Ionascu, Dan⁷ (AUTHOR) ionasctn@ucmail.uc.edu, Harun, Nusrat⁸ (AUTHOR) nusratharun77@hotmail.com, Vallabhapurapu, Subrahmanya⁹ (AUTHOR) subrahmaya@gmail.com, Wang, Chenran¹⁰ (AUTHOR) wang2cr@ucmail.uc.edu, Qi, Xiaoyang⁹ (AUTHOR) qix@ucmail.uc.edu, Baschnagel, Andrew M.¹¹ (AUTHOR) baschnagel@humonc.wisc.edu, Kritzer, Joshua A.⁴ (AUTHOR) joshua.kritzer@tufts.edu, Cook, James M.³ (AUTHOR) capncook@uwm.edu

Publikováno v: Cancers. Sep2024, Vol. 16 Issue 18, p3167. 30p.