Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Donatella Buonfiglio"'
Autor:
Valter Redoglia, Charles A. Janeway, Sara Bonissoni, Manuela Bragardo, Rosanna Vaschetto, Caterina Mezzatesta, Donatella Buonfiglio, Umberto Dianzani, Flavia Bottarel, Thea Bensi
Publikováno v:
European Journal of Immunology. 30:3463-3467
The recently cloned CD28-like molecule ICOS displays striking similarities with H4, characterized some years ago in the mouse and recently in humans. Both molecules are selectively expressed by activated and germinal center T cells, display similar s
Autor:
Fabio Malavasi, Manuela Bragardo, Ugo Ramenghi, Sara Bonissoni, Simona DeFranco, Umberto Dianzani, Donatella Buonfiglio, María José Feito, Flavia Bottarel, Thea Bensi
Publikováno v:
AIDS Research and Human Retroviruses. 15:1255-1263
CD4 cross-linking by HIV gp120 triggers CD4+ T cell death. Several authors have suggested that this effect is mediated by CD95, but this possibility is debated by other authors. In a previous work, we found by co-capping that gp120(451) and gp120MN,
Autor:
Junji Yagi, Umberto Dianzani, Hidehito Kato, Toshihiro Okamoto, Tomoko Katsurada, Donatella Buonfiglio, Tohru Miyoshi-Akiyama, Takehiko Uchiyama
Publikováno v:
The Journal of Immunology. 163:3083-3091
We examined the expression of the H4 T cell activation marker in thymic T cell subpopulations and found that TCR-αβ+ CD4+ thymic T cells are segregated into three subpopulations based upon H4 levels. Thymic T cells with either no or low H4 expressi
Autor:
Fabio Malavasi, Sara Bonissoni, Flavia Bottarel, Manuela Bragardo, Umberto Dianzani, Donatella Buonfiglio, María José Feito
Publikováno v:
International Immunology. 9:1141-1147
This work extends our previous finding that lymphocyte treatment with gp120IIIB specifically induces CD4 association with several surface molecules to other molecules and to three other gp120s from different HIV-1 strains. The ability to induce this
Autor:
Hidehito Kato, Donatella Buonfiglio, Junji Yagi, Umberto Dianzani, Yutaka Arimura, Soichiro Kamekura, Toshihiro Okamoto, Takehiko Uchiyama, Tohru Miyoshi-Akiyama
Publikováno v:
International immunology. 14(6)
We examined the co-stimulatory activity of H4/ICOS on murine activated CD4(+) T cells and found that the cross-linking of H4/ICOS enhanced their proliferation, in addition to raising IFN-gamma, IL-4 and IL-10 production to levels comparable to those
Autor:
Irma Dianzani, Sara Bonissoni, Manuela Bragardo, Donatella Buonfiglio, Daniela DiFranco, Roberto Cauda, Maria Rosaria Capobianchi, Caterina Mezzatesta, Flavia Bottarel, Thea Bensi, Claudia Balotta, Umberto Dianzani, M. B. Lucia
Publikováno v:
The hematology journal : the official journal of the European Haematology Association. 2(4)
INTRODUCTION In acquired immune deficiency syndrome patients, apoptosis of uninfected lymphocytes may contribute to development of immune deficiency. This process may involve recruitment of Fas by human immunodeficiency virus products. In line with t
Autor:
Luigi Ortona, Donatella Buonfiglio, Carlo Rumi, Charles A. Janeway, Flavia Bottarel, Thea Bensi, Sergio Rutella, Umberto Dianzani, M. B. Lucia, Roberto Cauda
Publikováno v:
AIDS research and human retroviruses. 16(6)
We have described hpH4, a surface glycoprotein selectively expressed by activated T cells and mature thymocytes and displaying weak lateral association with CD4. The hpH4 expression pattern and biochemical features, together with analysis of its tryp
Autor:
Antonino Carbone, Gianluca Gaidano, Kaarle Franssila, Manuela Bragardo, Vito L. Burgio, Roberto Cauda, Sara Bonissoni, Simona Zupo, Charles A. Janeway, Henrik Wolff, Donatella Buonfiglio, Valter Redoglia, Umberto Dianzani
Publikováno v:
European journal of immunology. 29(9)
We have previously characterized mouse H4 (mH4), a surface glycoprotein recognized by the C398.4A monoclonal antibody. We now show that C398.4A also binds its human putative homolog (hpH4). Both hpH4 and mH4 (1) are selectively expressed by activated
Autor:
Sara Bonissoni, José M. Rojo, Henrik Wolff, Manuela Bragardo, Umberto Dianzani, Charles A. Janeway, Donatella Buonfiglio, Pilar Portolés, Valter Redoglia
Publikováno v:
European journal of immunology. 26(11)
The monoclonal antibody C398.4A was produced by immunizing Armenian hamsters with the mouse T cell clone D10.G4.1. It recognizes a molecule selectively expressed by activated mouse T cells and was named H4. H4 is expressed on the T cell surface about
Autor:
Donatella Buonfiglio, Ada Funaro, Manuela Bragardo, Umberto Dianzani, Pilar Portolés, José M. Rojo, Valter Redoglia, Alessandro Pileri, Fabio Malavasi
Publikováno v:
European journal of immunology. 25(5)
CD4, a lymphocyte surface glycoprotein, serves as co-receptor for antigen with the T cell receptor (TCR). It is also the lymphocyte receptor for HIV by binding the gp120 viral envelope protein. Interaction of gp120 with CD4 is crucial for viral infec