Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Donatella, Bagetta"'
1
Akademický článek
Benzo[b]tiophen-3-ol derivatives as effective inhibitors of human monoamine oxidase: design, synthesis, and biological activity
Autor: Paolo Guglielmi, Daniela Secci, Anél Petzer, Donatella Bagetta, Paola Chimenti, Giulia Rotondi, Claudio Ferrante, Lucia Recinella, Sheila Leone, Stefano Alcaro, Gokhan Zengin, Jacobus P. Petzer, Francesco Ortuso, Simone Carradori
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1511-1525 (2019)
A series of benzo[b]thiophen-3-ols were synthesised and investigated as potential human monoamine oxidase (hMAO) inhibitors in vitro as well as ex vivo in rat cortex synaptosomes by means of evaluation of 3,4-dihydroxyphenylacetic acid/dopamine (DOPA
Externí odkaz: https://doaj.org/article/7280406604314cb88e2b4f9137207ce4
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2
Akademický článek
4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis
Autor: Daniela Secci, Simone Carradori, Anél Petzer, Paolo Guglielmi, Melissa D’Ascenzio, Paola Chimenti, Donatella Bagetta, Stefano Alcaro, Gokhan Zengin, Jacobus P. Petzer, Francesco Ortuso
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 597-612 (2019)
A new series of 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives were designed, synthesised, and evaluated to assess their inhibitory effect on the human monoamine oxidase (hMAO) A and B isoforms. Different (un)substituted (hetero)aromatic substitu
Externí odkaz: https://doaj.org/article/5a66b83f76a94eb594765e493cf83d5e
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3
Akademický článek
The Mu.Ta.Lig. Chemotheca: A Community-Populated Molecular Database for Multi-Target Ligands Identification and Compound-Repurposing
Autor: Francesco Ortuso, Donatella Bagetta, Annalisa Maruca, Carmine Talarico, Maria L. Bolognesi, Norbert Haider, Fernanda Borges, Sharon Bryant, Thierry Langer, Hanoch Senderowitz, Stefano Alcaro
Publikováno v: Frontiers in Chemistry, Vol 6 (2018)
For every lead compound developed in medicinal chemistry research, numerous other inactive or less active candidates are synthetized/isolated and tested. The majority of these compounds will not be selected for further development due to a sub-optima
Externí odkaz: https://doaj.org/article/48ebb914cdde44b993c7c7060ad90c09
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4
Design and synthesis of chromone-based monoamine oxidase B inhibitors with improved drug-like properties
Autor: Joana Reis, Carlos Fernandes, Hoda Salem, Marta Maia, Cláudia Tomé, Sofia Benfeito, José Teixeira, Paulo J. Oliveira, Eugenio Uriarte, Francesco Ortuso, Stefano Alcaro, Donatella Bagetta, Fernando Cagide, Fernanda Borges
Publikováno v: European journal of medicinal chemistry. 239
The absence of disease modifying drugs in Parkinson's disease therapy urges for new chemical entities acting on relevant PD-associated biological targets. As a result, developing selective and reversible inhibitors targeting MAO-B is still a desirabl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa085e4699884acd295c10b3f2e2df87
https://pubmed.ncbi.nlm.nih.gov/35772321
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5
Evaluation of chromane derivatives: Promising privileged scaffolds for lead discovery within Alzheimer's disease
Autor: Amina Moutayakine, Carolina Marques, Óscar López, Donatella Bagetta, Luisa Leitzbach, Stefanie Hagenow, Elisabete P. Carreiro, Holger Stark, Stefano Alcaro, José G. Fernández-Bolaños, Anthony J. Burke
Publikováno v: Bioorganicmedicinal chemistry. 68
The chromane ring system is widely distributed in nature and has proven to be a highly potent pharmacophore in medicinal chemistry, which includes the area of Alzheimer's and Parkinson's diseases. We report on the development of a gem-dimethylchroman
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9043b74cdafc33f2ba2ec3cbeee78128
https://pubmed.ncbi.nlm.nih.gov/35653868
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6
4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis
Autor: Gokhan Zengin, Melissa D'Ascenzio, Stefano Alcaro, Anél Petzer, Paolo Guglielmi, Daniela Secci, Simone Carradori, Francesco Ortuso, Jacobus P. Petzer, Paola Chimenti, Donatella Bagetta
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 597-612 (2019)
WOS: 000457961800001
PubMed: 30727777
A new series of 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives were designed, synthesised, and evaluated to assess their inhibitory effect on the human monoamine oxidase (hMAO) A and B isoforms. Dif
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a6718bd21424aa2f15a4fb469c36fb
https://doi.org/10.1080/14756366.2019.1571272
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10
Coumarin versus Chromone Monoamine Oxidase B Inhibitors: Quo Vadis?
Autor: Tiago H. Silva, Francesco Ortuso, Eugenio Uriarte, Maria João Matos, Joana Reis, Stefano Alcaro, André Fonseca, Fernanda Borges, Donatella Bagetta
Publikováno v: Journal of Medicinal Chemistry. 60:7206-7212
Because of the lack of significant disease-modifying drugs for neurodegenerative disorders, a pressing need for new chemical entities endowed with IMAO-B still exists. Within this framework, and for the first time, a study was performed to compare co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5de2b7750d21eea2b03c30e132c75e
https://doi.org/10.1021/acs.jmedchem.7b00918
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