Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Donalyn L. Scheuner"'
Autor:
Insook Jang, Anita Pottekat, Juthakorn Poothong, Jing Yong, Jacqueline Lagunas-Acosta, Adriana Charbono, Zhouji Chen, Donalyn L Scheuner, Ming Liu, Pamela Itkin-Ansari, Peter Arvan, Randal J Kaufman
Publikováno v:
eLife, Vol 8 (2019)
Regulated proinsulin biosynthesis, disulfide bond formation and ER redox homeostasis are essential to prevent Type two diabetes. In ß cells, protein disulfide isomerase A1 (PDIA1/P4HB), the most abundant ER oxidoreductase of over 17 members, can int
Externí odkaz:
https://doaj.org/article/606748e9851d4069a19e7e64c04c8f22
Autor:
Justin R Hassler, Donalyn L Scheuner, Shiyu Wang, Jaeseok Han, Vamsi K Kodali, Philip Li, Julie Nguyen, Jenny S George, Cory Davis, Shengyang P Wu, Yongsheng Bai, Maureen Sartor, James Cavalcoli, Harmeet Malhi, Gregory Baudouin, Yaoyang Zhang, John R Yates, Pamela Itkin-Ansari, Niels Volkmann, Randal J Kaufman
Publikováno v:
PLoS Biology, Vol 13, Iss 10, p e1002277 (2015)
Although glucose uniquely stimulates proinsulin biosynthesis in β cells, surprisingly little is known of the underlying mechanism(s). Here, we demonstrate that glucose activates the unfolded protein response transducer inositol-requiring enzyme 1 al
Externí odkaz:
https://doaj.org/article/10407ba79b154e0899dd1b1e445895a1
Autor:
Jing Yong, Peter Arvan, Ming Liu, Juthakorn Poothong, Insook Jang, Adriana Charbono, Jacqueline Lagunas-Acosta, Randal J. Kaufman, Zhouji Chen, Pamela Itkin-Ansari, Anita Pottekat, Donalyn L Scheuner
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
Regulated proinsulin biosynthesis, disulfide bond formation and ER redox homeostasis are essential to prevent Type two diabetes. In ß cells, protein disulfide isomerase A1 (PDIA1/P4HB), the most abundant ER oxidoreductase of over 17 members, can int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34bbb24fe15739dc0b6b715fbaf5a284
https://doi.org/10.7554/elife.44528
https://doi.org/10.7554/elife.44528
Autor:
Juthakorn Poothong, Anita Pottekat, Jing Yong, Jacqueline Lagunas-Acosta, Pamela Itkin-Ansari, Adriana Charbono, Peter Arvan, Donalyn L Scheuner, Insook Jang, Zhouji Chen, Randal J. Kaufman, Ming Liu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb9249a3fb350d5313de1acece2889ed
https://doi.org/10.7554/elife.44528.019
https://doi.org/10.7554/elife.44528.019
Autor:
Shiyu Wang, Yaoyang Zhang, Harmeet Malhi, James D. Cavalcoli, Vamsi K. Kodali, Jaeseok Han, Philip Li, Yongsheng Bai, Justin R. Hassler, Donalyn L. Scheuner, Maureen A. Sartor, Jenny S. George, John R. Yates, Cory Davis, Niels Volkmann, Pamela Itkin-Ansari, Gregory Baudouin, Randal J. Kaufman, Julie Nguyen, Shengyang P. Wu
Publikováno v:
PLoS Biology
PLoS Biology, Vol 13, Iss 10, p e1002277 (2015)
PLoS Biology, Vol 13, Iss 10, p e1002277 (2015)
Although glucose uniquely stimulates proinsulin biosynthesis in β cells, surprisingly little is known of the underlying mechanism(s). Here, we demonstrate that glucose activates the unfolded protein response transducer inositol-requiring enzyme 1 al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b17364ced08cb7252570b8653b965b
http://europepmc.org/articles/PMC4607427
http://europepmc.org/articles/PMC4607427
Autor:
Natalie Gilks, Randal J. Kaufman, Anping Han, Nancy Kedersha, J J Chen, Paul A. Anderson, Benbo Song, Donalyn L Scheuner, Edward McEwen
Publikováno v:
Journal of Biological Chemistry. 280:16925-16933
Exposure to arsenite inhibits protein synthesis and activates multiple stress signaling pathways. Although arsenite has diverse effects on cell metabolism, we demonstrated that phosphorylation of eukaryotic translation initiation factor 2 at Ser-51 o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703459bf1e8baa38791be2cabaca6d4e
https://doi.org/10.1074/jbc.m412882200
https://doi.org/10.1074/jbc.m412882200
Autor:
Heather P. Harding, Phoebe D. Lu, Yuhong Zhang, Stefan J. Marciniak, David Ron, Isabel Novoa, Donalyn L Scheuner, Céline Jousse, Randal J. Kaufman
Publikováno v:
The EMBO journal. 23(1)
Transient phosphorylation of the alpha-subunit of translation initiation factor 2 (eIF2alpha) represses translation and activates select gene expression under diverse stressful conditions. Defects in the eIF2alpha phosphorylation-dependent integrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16158654e3e341c5d636ce8a0c734ce7
https://pubmed.ncbi.nlm.nih.gov/14713949
https://pubmed.ncbi.nlm.nih.gov/14713949