Výsledky vyhledávání - "Donald W. Kufe"

Akademický článek

MUC1-C is a target of salinomycin in inducing ferroptosis of cancer stem cells

Autor: Tatsuaki Daimon, Atrayee Bhattacharya, Keyi Wang, Naoki Haratake, Ayako Nakashoji, Hiroki Ozawa, Yoshihiro Morimoto, Nami Yamashita, Takeo Kosaka, Mototsugu Oya, Donald W. Kufe

Publikováno v: Cell Death Discovery, Vol 10, Iss 1, Pp 1-14 (2024)

Abstract The oncogenic MUC1-C transmembrane protein is a critical effector of the cancer stem cell (CSC) state. Addiction to MUC1-C for self-renewal in the progression of human cancers has emphasized the need for development of anti-MUC1-C agents. Ho

Externí odkaz: https://doaj.org/article/40f01229ba0446f2b048809686dea194

Zobrazit plný text záznamu

Akademický článek

Induction of circulating phospholipase A2 by intravenous administration of recombinant human tumour necrosis factor

Autor: Waldemar Pruzanski, Matthew L. Sherman, Donald W. Kufe, Peter Vadas

Publikováno v: Mediators of Inflammation, Vol 1, Iss 4, Pp 235-240 (1992)

We have examined the effects of intravenous infusion of recombinant human tumour necrosis factor (rh-TNF) on serum activity of phospholipase A2 (PLA2) in patients with malignancies. Nine patients received a 24 h continuous intravenous infusion rangin

Externí odkaz: https://doaj.org/article/3297b9ae53574cef881c94ae28ee3bf7

Zobrazit plný text záznamu

Supplementary Figure 8 from CBS9106-Induced CRM1 Degradation Is Mediated by Cullin Ring Ligase Activity and the Neddylation Pathway

Autor: Takumi Kawabe, Daniel D. VonHoff, Donald W. Kufe, Jonathan M. Friedman, Takuji Sato, Keiichi Sakakibara, Naoya Saito

Supplementary Figure 8: MLN4924 attenuates tumor growth inhibition by CBS9106 in human xenograft model. (A) SCID mice bearing HCT116 tumor xenografts are treated with vehicle (5% GA, p.o. + 10% HBC, s.c.), CBS9106 (250 mg/kg p.o. once per week), MLN4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9e48038b36b2f6bd252c9bd54185c9
https://doi.org/10.1158/1535-7163.22499652.v1

Zobrazit plný text záznamu

Data Supplement from Activation of Nrf2 Pathways Correlates with Resistance of NSCLC Cell Lines to CBP501 In Vitro

Autor: Takumi Kawabe, Daniel D. Von Hoff, Donald W. Kufe, Sayaka Yamamoto, Naoki Mine

Supplemental Table 1. Keap1 mutation in NSCLC cell lines. Supplemental Figure 1. Comparative analysis of individual gene expression as in CBP501 insensitive cell lines or the CBP501 sensitive cell lines from figure 2. Black bars indicate the average

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da9346284308e30c96024634152a54cd
https://doi.org/10.1158/1535-7163.22501819.v1

Zobrazit plný text záznamu

Data from CBP501-Calmodulin Binding Contributes to Sensitizing Tumor Cells to Cisplatin and Bleomycin

Autor: Takumi Kawabe, Daniel D. Von Hoff, Donald W. Kufe, Machiyo Ishigaki, Chikako Suda, Satoshi Yamazaki, Naoya Saito, Sayaka Yamamoto, Naoki Mine

CBP501 is an anticancer drug currently in randomized phase II clinical trials for patients with non–small cell lung cancer and malignant pleural mesothelioma. CBP501 was originally described as a unique G2 checkpoint-directed agent that binds to 14

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a573389697e666d78dceabb2f7cd7e13
https://doi.org/10.1158/1535-7163.c.6535212.v1

Zobrazit plný text záznamu

Supplementary Figure 2 from CBS9106-Induced CRM1 Degradation Is Mediated by Cullin Ring Ligase Activity and the Neddylation Pathway

Autor: Takumi Kawabe, Daniel D. VonHoff, Donald W. Kufe, Jonathan M. Friedman, Takuji Sato, Keiichi Sakakibara, Naoya Saito

Supplementary Figure 2: MLN4924 (50 nM) increases subG1 and DNA content. HCT116 cells are treated with increasing concentrations of MLN4924 (0, 1, 10, or 50 nM) for 72 hours. The population is measured by flow cytometry after staining with propidium

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0edb3814a383b57738d98b140c3658f0
https://doi.org/10.1158/1535-7163.22499670

Zobrazit plný text záznamu

Supplementary Figure 1 from CBS9106-Induced CRM1 Degradation Is Mediated by Cullin Ring Ligase Activity and the Neddylation Pathway

Autor: Takumi Kawabe, Daniel D. VonHoff, Donald W. Kufe, Jonathan M. Friedman, Takuji Sato, Keiichi Sakakibara, Naoya Saito

Supplementary Figure 1: CBS9106 reduces CRM1 protein levels through neddylation -mediated degradation in MM.1S cells. (A) MM.1S cells are treated with CBS9106 (50 nM) and/or MLN4924 (100 nM) for indicated period (0-8 hours). (B) Cells are treated wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d1dac22335be4ababc4fd71cffe4c02
https://doi.org/10.1158/1535-7163.22499673

Zobrazit plný text záznamu

Supplementary Figure 6 from CBS9106-Induced CRM1 Degradation Is Mediated by Cullin Ring Ligase Activity and the Neddylation Pathway

Autor: Takumi Kawabe, Daniel D. VonHoff, Donald W. Kufe, Jonathan M. Friedman, Takuji Sato, Keiichi Sakakibara, Naoya Saito

Supplementary Figure 6: Inhibitors of autophagy do not interfere with the efficacy of low dose MLN4924. HCT116 cells are treated with CBS9106 (100 nM), MLN4924 (50 nM or 1 microM) or 3-MA (5 mM) alone or in combination for 24 hours. Protein levels of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a8e928ca7b4deccfebb2571b0bc4b5
https://doi.org/10.1158/1535-7163.22499658

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání