Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Donald V. Daniels"'
Publikováno v:
European Journal of Pharmacology. 504:155-167
The objective of this study was to pharmacologically characterize bradykinin receptors, a component of the kallikrein-kinin system, in normal human prostate cells. In primary cultured human prostate stromal cells, bradykinin, but not [des-Arg9]bradyk
Autor:
Anthony P.D.W. Ford, Joel R Gever, H.M. Tang, Timothy J. Williams, Donald V. Daniels, D.R. Blue, Mary-Frances Jett, Counde O'yang
Publikováno v:
BJU International. 93:162-170
OBJECTIVE To describe the preclinical pharmacology of Ro 115–1240, a peripherally acting selective α1A/1L-adrenoceptor (AR) partial agonist, compared with the α1A/1L-AR full agonist amidephrine, as AR agonists have some utility in the treatment o
Publikováno v:
British Journal of Pharmacology. 132:1606-1614
Muscarinic cholinoceptors (MChR) in freshly dispersed rat salivary gland (RSG) cells were characterized using microphysiometry to measure changes in acidification rates. Several non-selective and selective muscarinic antagonists were used to elucidat
Autor:
Anthony P.D.W. Ford, R.L. Vimont, Richard M. Eglen, Todd R. Elworthy, David Ernest Clarke, Fernando Padilla, Donald V. Daniels, Russ Chess-Williams, Joel R Gever, Christopher R. Chapple, S Tassa, M S Kava, Timothy J. Williams, David J. Morgans, B Davis, D.R. Blue
Publikováno v:
British Journal of Pharmacology. 127:252-258
It has been hypothesized that in patients with benign prostatic hyperplasia, selective antagonism of the alpha1A-adrenoceptor-mediated contraction of lower urinary tract tissues may, via a selective relief of outlet obstruction, lead to an improvemen
Publikováno v:
British Journal of Pharmacology. 127:590-596
1. Affinity estimates were obtained for several muscarinic antagonists against carbachol-stimulated [3H]-inositol phosphates accumulation in Chinese hamster ovary (CHO-KI) cells stably expressing either human muscarinic M3 or M5 receptor subtypes. Th
Autor:
Alan Kosaka, David J. Chang, Donald V. Daniels, Jeffrey R. Jasper, Anthony P.D.W. Ford, Richard M. Eglen, Chinh Bach, Hardy W. Chan, Sunil Bhakta, Thomas Chang, John D Lesnick, Reena Khare, Ing-Shih Shieh, David E. Clarke, Susan S Yamanishi, F.H.Rick Salazar
Publikováno v:
FEBS Letters. 422:279-283
We have isolated and characterized from human prostate novel splice variants of the human alpha1A-adrenoceptor, several of which generate truncated products and one isoform, alpha(1A-4), which has the identical splice site as the three previously des
Autor:
Anthony P.D.W. Ford, David J. Chang, Joel R Gever, Jeffrey R. Jasper, David E. Clarke, Donald V. Daniels, John D Lesnick
Publikováno v:
British Journal of Pharmacology. 121:1127-1135
1. Three fully-defined alpha1-adrenoceptors (alpha1A, alpha1B and alpha1D) have been established in pharmacological and molecular studies. A fourth alpha1-adrenoceptor, the putative alpha1L-adrenoceptor, has been defined in functional but not molecul
Autor:
Donald V. Daniels, Robert Alvarez
Publikováno v:
Analytical Biochemistry. 236:367-369
Autor:
Donald V. Daniels, Anthony P.D.W. Ford, Leah R. Burbach, Anindya Bhattacharya, Dinesh Srinivasan
Publikováno v:
British journal of pharmacology. 142(2)
The objective of this study was to characterize pharmacologically bradykinin (Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg, BK) receptors in the canine prostate. Primary cultures of canine prostate stromal (PS) and epithelial cells (PE) were established and t
Autor:
David J. Chang, John D Lesnick, Jeffrey R. Jasper, David E. Clarke, Donald V. Daniels, George Stepan, Trena D. Meloy, Timothy J. Williams, Joel R Gever, Anthony P.D.W. Ford, M. Shannon Kava
Publikováno v:
European journal of pharmacology. 370(3)
The recombinant alpha1A-adrenoceptor displays a distinct pharmacological profile ('classical alpha1A-adrenoceptor') in homogenate binding assays, but displays the properties of the so-called alpha1L-adrenoceptor in functional studies in whole cells a