Zobrazeno 1 - 10 of 185 pro vyhledávání: '"Donald T. Witiak"'
1
Synthesis of All Distinct α-Methyl-Substituted Isomers of Amino Bis(2,2′-Ethanoic Acid) Diethyl Ester and Ethylene Diamine Tetraacetic Acid Tetraethyl Ester Scaffolds
Autor: Shabana S. Insaf, Donald T. Witiak
Publikováno v: Tetrahedron. 56:2359-2367
The syntheses of three dialkylated and six tetraalkylated ethylene diamine tetraacetic acid tetraesters is described. The dialkylated derivatives were synthesized by a convergent non-racemizing route to yield three enantiomerically and diastereomeric
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ffdca089cd779bdb6d8edad2faddf43
https://doi.org/10.1016/s0040-4020(00)00103-4
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2
A Structure-Function Analysis of DNA Topoisomerase II Inhibitors
Autor: Shabana S. lnsaf, Mary K. Danks, Donald T. Witiak
Publikováno v: Current Medicinal Chemistry. 3:437-466
DNA topoisomerases are ubiquitous enzymes that catalyze the interconversion of different topological forms of DNA. Topoisomerases are expressed at higher levels in logarithmically growing cells than in quiescent cells. Possibly, this enables differen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16ab8d6b97add7572a6bbf61f3ed966a
https://doi.org/10.2174/0929867303666220307180003
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4
Design, Synthesis, and Biological Evaluation of Conformationally Constrainedaci-Reductone Mimics of Arachidonic Acid
Autor: John Andrew Ziemniak, Allen T. Hopper, Donald T. Witiak
Publikováno v: Journal of Medicinal Chemistry. 41:420-427
An efficient and convergent synthesis has been developed for the production of 3,4-dihydroxy-5-[4-(2-((2Z)-hexenyl)phenyl)-3-(1Z)-but enyl]-2 (5H)-furanone (12d). This hydrophobic antioxidant is a stable conformationally constrained mimic of arachido
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa6f150574e7530a86fcb9051443c949
https://doi.org/10.1021/jm970034q
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5
Inhibition of topoisomerase II by ICRF-193, the meso isomer of 2,3-bis(2,6-dioxopiperazin-4-yl)butane
Autor: Andrei V. Blokhin, Donald T. Witiak, Robert M. Snapka, Sung Ho Woo
Publikováno v: Biochemical Pharmacology. 52:543-549
The bis(2,6-dioxopiperazine)s are a structurally and mechanistically unique class of topoisomerase II inhibitors that do not bind DNA and that do not stabilize topoisomerase II-DNA strand passing intermediates (“cleavable complexes”). The most ef
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebcfcbea3413c27a16014595c7ba98a0
https://doi.org/10.1016/0006-2952(96)00305-x
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7
Inhibitors of Cyclooxygenase and 5-Lipoxygenase
Autor: Padmaja Mantri, Donald T. Witiak
Publikováno v: Current Medicinal Chemistry. 1:328-355
Abstract: Prostaglandin H synthase (PGH synthase) and 5-Lipoxygenase (5-LO) are important enzymes that catalyze the formation of putative intermediates involved in the inflammatory process. The mechanism by which PGH synthase and 5-LO convert their c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a691ae35c70f3c1c4acc234a56dd5c8
https://doi.org/10.2174/092986730104220215155510
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8
Inhibition of low density lipoprotein oxidation by thyronines and probucol
Autor: Howard A. I. Newman, Dennis R. Feller, Atef N. Hanna, Donald T. Witiak
Publikováno v: Biochemical Pharmacology. 45:753-762
Oxidation of low density lipoproteins (LDL) results in increased macrophage uptake of LDL which may contribute to the formation of macrophage-derived foam cells in the early atherosclerotic lesion. In this study we show that thyroxine (T 4 ), its opt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6917fbb2484c909c52735e070f86a4de
https://doi.org/10.1016/0006-2952(93)90151-l
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