Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Donald T Fox"'
Autor:
Scott R Allen, Rebeccah K Stewart, Michael Rogers, Ivan Jimenez Ruiz, Erez Cohen, Alain Laederach, Christopher M Counter, Jessica K Sawyer, Donald T Fox
Publikováno v:
eLife, Vol 11 (2022)
Codon usage bias has long been appreciated to influence protein production. Yet, relatively few studies have analyzed the impacts of codon usage on tissue-specific mRNA and protein expression. Here, we use codon-modified reporters to perform an organ
Externí odkaz:
https://doaj.org/article/6c13272b3ef34ec284eeebefc16be53b
Autor:
Jessica K Sawyer, Zahra Kabiri, Ruth A Montague, Scott R Allen, Rebeccah Stewart, Sarah V Paramore, Erez Cohen, Hamed Zaribafzadeh, Christopher M Counter, Donald T Fox
Publikováno v:
PLoS Genetics, Vol 16, Iss 12, p e1009228 (2020)
Signal transduction pathways are intricately fine-tuned to accomplish diverse biological processes. An example is the conserved Ras/mitogen-activated-protein-kinase (MAPK) pathway, which exhibits context-dependent signaling output dynamics and regula
Externí odkaz:
https://doaj.org/article/1f52412526d54987811d70aa950d6506
Autor:
Nora G Peterson, Benjamin M Stormo, Kevin P Schoenfelder, Juliet S King, Rayson RS Lee, Donald T Fox
Publikováno v:
eLife, Vol 9 (2020)
Multiple nuclei sharing a common cytoplasm are found in diverse tissues, organisms, and diseases. Yet, multinucleation remains a poorly understood biological property. Cytoplasm sharing invariably involves plasma membrane breaches. In contrast, we di
Externí odkaz:
https://doaj.org/article/87d16708ab3648229a10c73117706167
Publikováno v:
eLife, Vol 7 (2018)
Ploidy-increasing cell cycles drive tissue growth in many developing organs. Such cycles, including endocycles, are increasingly appreciated to drive tissue growth following injury or activated growth signaling in mature organs. In these organs, the
Externí odkaz:
https://doaj.org/article/feba17ecd970426ba3408ed2d432b258
Autor:
Rebeccah K. Stewart, Patrick Nguyen, Alain Laederach, Pelin C. Volkan, Jessica K. Sawyer, Donald T. Fox
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Regulation of codon optimality is an increasingly appreciated layer of cell- and tissue-specific protein expression control. Here, we use codon-modified reporters to show that differentiation of Drosophila neural stem cells into neurons enab
Externí odkaz:
https://doaj.org/article/ebf9891368994effa71105e61f20d572
Autor:
Benjamin M Stormo, Donald T Fox
Publikováno v:
eLife, Vol 5 (2016)
Duplicating chromosomes once each cell cycle produces sister chromatid pairs, which separate accurately at anaphase. In contrast, reduplicating chromosomes without separation frequently produces polytene chromosomes, a barrier to accurate mitosis. Ch
Externí odkaz:
https://doaj.org/article/1a891a4591c0470fab48ae914dca7f98
Autor:
Rihana S. Bokhari, Afshin Beheshti, Sarah E. Blutt, Dawn E. Bowles, David Brenner, Robert Britton, Lawrence Bronk, Xu Cao, Anushree Chatterjee, Delisa E. Clay, Colleen Courtney, Donald T. Fox, M.Waleed Gaber, Sharon Gerecht, Peter Grabham, David Grosshans, Fada Guan, Erin A. Jezuit, David G. Kirsch, Zhandong Liu, Mirjana Maletic-Savatic, Kyle M. Miller, Ruth A. Montague, Prashant Nagpal, Sivan Osenberg, Luke Parkitny, Niles A. Pierce, Christopher Porada, Susan M. Rosenberg, Paul Sargunas, Sadhana Sharma, Jamie Spangler, Daniel Naveed Tavakol, Dilip Thomas, Gordana Vunjak-Novakovic, Chunbo Wang, Luke Whitcomb, Damian W. Young, Dorit Donoviel
Publikováno v:
Life Sciences in Space Research. 35:105-112
Future lunar missions and beyond will require new and innovative approaches to radiation countermeasures. The Translational Research Institute for Space Health (TRISH) is focused on identifying and supporting unique approaches to reduce risks to huma
Autor:
Archan Chakraborty, Nora G. Peterson, Juliet S. King, Ryan T. Gross, Michelle Mendiola Pla, Aatish Thennavan, Kevin C. Zhou, Sophia DeLuca, Nenad Bursac, Dawn E. Bowles, Matthew J. Wolf, Donald T. Fox
Publikováno v:
bioRxiv
SUMMARYDevelopmentally programmed polyploidy (whole-genome-duplication) of cardiomyocytes is common across evolution. Functions of such polyploidy are essentially unknown. Here, we reveal roles for precise polyploidy levels in cardiac tissue. We high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92896fde057234d266b1c5ce0d45b42a
https://europepmc.org/articles/PMC9934670/
https://europepmc.org/articles/PMC9934670/
Publikováno v:
Methods in Molecular Biology ISBN: 9781071625606
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::277e6b789c12d112a0225eedda78e867
https://doi.org/10.1007/978-1-0716-2561-3_21
https://doi.org/10.1007/978-1-0716-2561-3_21
Autor:
Nora G. Peterson, Donald T. Fox
Publikováno v:
Chromosome Research
Multicellular organisms are composed of tissues with diverse cell sizes. Whether a tissue primarily consists of numerous, small cells as opposed to fewer, large cells can impact tissue development and function. The addition of nuclear genome copies w